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  • 1
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    Endostatin lowers blood pressure via nitric oxide [Medical Sciences] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-07-11
    Description: Antiangiogenesis therapy has become a vital part of the armamentarium against cancer. Hypertension is a dose-limiting toxicity for VEGF inhibitors. Thus, there is a pressing need to address the associated adverse events so these agents can be better used. The hypertension may be mediated by reduced NO bioavailability resulting from VEGF inhibition. We proposed that the hypertension may be prevented by coadministration with endostatin (ES), an endogenous angiogenesis inhibitor with antitumor effects shown to increase endothelial NO production in vitro. We determined that Fc-conjugated ES promoted NO production in endothelial and smooth muscle cells. ES also lowered blood pressure in normotensive mice and prevented hypertension induced by anti-VEGF antibodies. This effect was associated with higher circulating nitrate levels and was absent in eNOS-knockout mice, implicating a NO-mediated mechanism. Retrospective study of patients treated with ES in a clinical trial revealed a small but significant reduction in blood pressure, suggesting that the findings may translate to the clinic. Coadministration of ES with VEGF inhibitors may offer a unique strategy to prevent drug-related hypertension and enhance antiangiogenic tumor suppression.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Genetics. Fragile X's missing partners identified (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sohn, E -- New York, N.Y. -- Science. 2001 Nov 30;294(5548):1809.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11729277" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Disease Models, Animal ; Drosophila melanogaster/genetics/metabolism ; Fragile X Mental Retardation Protein ; Fragile X Syndrome/*etiology/genetics/*metabolism ; *Gene Expression Regulation ; Gene Library ; Humans ; Mice ; Microtubule-Associated Proteins/genetics/*metabolism ; Mutation/genetics ; Nerve Tissue Proteins/*metabolism ; Phenotype ; RNA, Messenger/chemistry/genetics/metabolism ; RNA-Binding Proteins/*metabolism ; Up-Regulation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Animal models: Dogged pursuit (2014)
    Nature Publishing Group (NPG)
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    Publication Date: 2014-11-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sohn, Emily -- England -- Nature. 2014 Nov 27;515(7528):S172-3. doi: 10.1038/515S172a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25427211" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease Models, Animal ; *Dogs ; Drug Evaluation, Preclinical/history ; Genetic Therapy ; Hemophilia A/*therapy ; Hemophilia B/*therapy ; History, 20th Century ; Research/trends
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    Malaria control: The great mosquito hunt (2014)
    Nature Publishing Group (NPG)
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    Publication Date: 2014-07-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sohn, Emily -- England -- Nature. 2014 Jul 10;511(7508):144-6. doi: 10.1038/511144a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25008507" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Culicidae/*physiology ; Dogs ; Humans ; Insect Vectors/*physiology ; Malaria/*prevention & control ; Mali ; *Mosquito Control ; Seasons
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Screening: Diagnostic dilemma (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sohn, Emily -- England -- Nature. 2015 Dec 17;528(7582):S120-2. doi: 10.1038/528S120a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26672781" target="_blank"〉PubMed〈/a〉
    Keywords: Early Diagnosis ; False Positive Reactions ; Humans ; Male ; Mass Screening/trends ; Prognosis ; Prostate-Specific Antigen/*blood ; Prostatic Neoplasms/*blood/*diagnosis/psychology ; Reproducibility of Results ; Risk Assessment ; Stress, Psychological/etiology/prevention & control
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    Screening: Don't look now (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-11-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sohn, Emily -- England -- Nature. 2015 Nov 19;527(7578):S118-9. doi: 10.1038/527S118a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26580162" target="_blank"〉PubMed〈/a〉
    Keywords: Breast Neoplasms/*diagnosis/psychology ; Female ; Humans ; Mammography/economics/*utilization ; Mass Screening/economics/*utilization ; Medical Overuse/economics/*prevention & control/*statistics & numerical data ; Stress, Psychological/prevention & control
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 7
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    Networking: Hello, stranger (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-10-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sohn, Emily -- England -- Nature. 2015 Oct 29;526(7575):729-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26516640" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 8
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    Contamination: The toxic side of rice (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-11-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sohn, Emily -- England -- Nature. 2014 Oct 30;514(7524):S62-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25368891" target="_blank"〉PubMed〈/a〉
    Keywords: Arsenic/analysis/*metabolism ; Arsenic Poisoning/epidemiology/prevention & control ; Bangladesh/epidemiology ; Crops, Agricultural/chemistry/metabolism ; Food Contamination/*analysis ; Humans ; Oryza/*chemistry/*metabolism ; United States ; Water Supply
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 9
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    Israel: Research without prejudice (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-09-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sohn, Emily -- England -- Nature. 2015 Sep 24;525(7570):S12-3. doi: 10.1038/525S12a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26398732" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biomedical Research ; Cannabidiol/administration & dosage/analogs & derivatives/therapeutic use ; *Cannabis ; Child ; Clinical Trials, Phase II as Topic/legislation & jurisprudence ; Craniocerebral Trauma/drug therapy ; Crohn Disease/drug therapy ; Drug Industry/organization & administration ; Female ; Humans ; Israel ; Medical Marijuana/administration & dosage/therapeutic use ; Mice ; Stress Disorders, Post-Traumatic/drug therapy
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 10
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    Fieldwork: Extreme research (2016)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2016-01-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sohn, Emily -- England -- Nature. 2016 Jan 14;529(7585):243-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26771043" target="_blank"〉PubMed〈/a〉
    Keywords: Altitude ; Animals ; Animals, Wild ; *Caves ; *Disaster Planning ; *Diving ; *Expeditions ; *Mountaineering ; *Research ; *Research Personnel/psychology ; Safety ; Survival
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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