ISSN:
0947-6539
Keywords:
benzazocines
;
benzazepines
;
carbonylations
;
cyclizations
;
zirconium
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The development of a new method for the intramolecular coupling of terminal alkynes and for the synthesis of seven- and eight-membered benzoheterocycles is reported. The key steps involve the generation of zirconocene-alkyne complexes from 2-bromoalkenes and the subsequent intramolecular carbometalation of olefins or acetylides. The 8-unsubstituted zirconabicyclopentenes were carbonylated to afford unexpected products and allow access to polyfunctionalized molecules from simple starting materials.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chem.19970030820
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