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The Pharmacokinetics of Trilostane and Ketotrilostane in an Interconverting System in the Rat (1992)

McGee, J. Paul ; Shaw, P. Nicholas

Springer

Pharmaceutical research 9 (1992), S. 464-468

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ISSN: 1573-904X

Keywords: trilostane ; ketotrilostane ; reversible metabolism ; pharmacokinetics ; metabolic interconversion

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract The pharmacokinetics of trilostane and one of its metabolites ketotrilostane are described and characterized in the rat following the separate intravenous administration of trilostane and ketotrilostane. It was noted during these studies that the parent compound and its metabolite undergo metabolic interconversion–trilostane producing ketotrilostane and ketotrilostane generating trilostane. This result means that trilostane is conserved in the body by interconversion-being metabolized to ketotrilostane and then subsequently back to the “parent” drug, trilostane.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1015828027060

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