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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Risk analysis 13 (1993), S. 0 
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Pharmacokinetic models which incorporate independently measured anatomical characteristics and physiological flows have been widely used to predict the pharmacokinetic behavior of drugs, anesthetics, and other chemicals. Models appearing in the literature have included as many as 18,(1) or as few as 5 tissue compartments.(2) With the exception of the multiple-compartment delay trains used by Bischoff(3) to model the delays inherent to the appearance of drug metabolites in bile and segments of the intestinal lumen, very little effort has been made to incorporate the available information on gastrointestinal anatomy and physiology into more accurate gastrointestinal absorption/enterohepatic recirculation submodels. Since several authors have shown that the lymphatic system is the most significant route of absorption for highly lipophilic chemicals, we have constructed a model of gastrointestinal absorption that emphasizes chylomicron production and transport as the most significant route of absorption for nonvolatile, lipophilic chemicals. The absorption and distribution of hexachlorobenzene after intravenous vs. oral dosing are used to demonstrate features of this model.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Risk analysis 6 (1986), S. 0 
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: A risk assessment comparing the acute effects of mineral oil and PCB-askarel dielectric fluids in two transformer sites was performed. The first site has the installation characteristics for a PCB-askarel-filled transformer with sprinkler fire protection. A risk comparison is made between two types of transformers (PCB-askarel-filled and mineral oil-filled) for this site. The second site (a vault) has the installation characteristics for a mineral oil-filled transformer, and a risk comparison is made in a fashion similar to the first site. Risk is expressed in terms of frequencies of one or more acute injuries or fatalities per transformer year.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Plant/Operations Progress 4 (1985), S. 85-89 
    ISSN: 0278-4513
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Plant/Operations Progress 10 (1991), S. 155-158 
    ISSN: 0278-4513
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The recently enacted Clean Air Act Amendments of 1990 [1] and the proposed OSHA Process Safety Management Standard [2] both require that hazard evaluations be completed on all facilities that handle hazardous chemicals. Reports of the hazard evaluations must be kept on file and will be subject to inspection during an OSHA compliance audit. This paper outlines those concepts that are important in the preparation of the documentation of a Hazards and Operability (HAZOP) study.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Plant/Operations Progress 9 (1990), S. 231-235 
    ISSN: 0278-4513
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: This paper focuses on the new Guidelines for Chemical Process Quantitative Risk Analysis recently published by the AIChE Center for Chemical Process Safety (CCPS). CCPS was formed soon after the disasters in Mexico City and Bhopal. CCPS was established in 1985 by the AIChE to develop and disseminate technical information for use in the prevention of major chemical accidents. The center is supported by over 60 industrial sponsors in the chemical process industry (CPI), who provide the necessary funding and professional guidance to its technical committees.The major product of CCPS activities has been a series of guideline books. Table I presents a list of the currently available CCPS guidelines. The first book, Guidelines for Hazard Evaluation Procedures (HEP), presented various structured qualitative techniques (HAZOP, FMEA, etc.) that could be used to identify possible hazards in a chemical facility. The Technical Steering Committee of CCPS decided that a sequel to HEP should be developed which would present quantitative methods for acute process hazards. The Guidelines for Chemical Process Quantitative Risk Analysis (CPQRA) resulted from that decision.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0278-4513
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Process Safety Progress 13 (1994), S. 146-152 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The design of high integrity interlock systems involves more than the simple specification of high-quality components. Redundancy of components is often used as a strategy to improve the reliability of an interlock system. This paper uses quantitative reliability engineering methods to explore the relationships of component reliability, time between proof tests, redundancy and common cause failures to overall system performance. The paper demonstrates that addition to redundancy often, but not always, improves the reliability of an interlock system. The paper also demonstrates how common cause failures can greatly reduce the chances of an interlock system performing when needed.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Process Safety Progress 16 (1997), S. 32-36 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Transportation of hazardous chemicals as raw materials or products from chemical process facilities presents special hazards. Recently, the Risk Assessment Subcommittee (RASC) of the AIChE Center for Chemical Process Safetly (CCPS) completed a three-year project which has been published in a CCPS Guidelines Series entitled Guidelines for Chemical Transportation Risk Analysis. The major themes of the book are summarized in this paper and the methods and techniques used in evaluating the risk of movement of hazardous chemicals are described. Guidelines for Chemical Transportation Risk Analysis covers methods that can be used to evaluate the risk of movement of a hazardous chemical by rail, barge, truck, pipeline, and ocean-going vessel. A simple example is presented using the methods discussed in the guidelines.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Process Safety Progress 16 (1997), S. 14-17 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The shipment of hazardous chemicals can pose signficant risk to the general public and the environment. These shipments are made in a variety of packages ranging from small bottles to large tank trucks, tank cars, and barges. However, the many standards and regulations that have been established to govern the design and use of these packages define what many consider to be the minimum requirements for risk management. This paper presents a methodology that can be used to more thoroughly identify the risk minimization options and verify the design of a package for a particular service. This method is based on the concept of a threat analysis of the proposed movement of the hazardous chemical. The threat analysis looks for unusual (but realistic) threats to the package that may result in the release of the hazardous chemical to the environment. Such unusual threats may include events such as: Dropping of the package during loading; Accident enroute; External fire during shipment; Random acts of vandalism (using the package as a practice target); Puncture (fork lift collision with package, rail/truck accident); Crushing (sudden starting or stopping). By conducting an engineering analysis of the strength and ability of the container to withstand these unusual events, a package design that can withstand the threats indentified in the threat analysis can be defined.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
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  • 10
    Publication Date: 1990-10-01
    Print ISSN: 0022-5193
    Electronic ISSN: 1095-8541
    Topics: Biology
    Published by Elsevier
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