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  • 1
    Publication Date: 1978-08-18
    Description: Lead (200 milligrams per kilogram) was administered daily by intubation to Long-Evans rats on days 3 through 30 of life. Thirty to 180 days after cessation of lead administration, the lead-treated rats were consistently more polydipsic after lithium administration (2 millimoles per kilogram per day) than were pair-treated controls. Lithium increased the plasma renin activity equally in both the lead treated and the control groups. These data are evidence that there may be permanent neural changes induced by postnatal exposure to lead that are manifested by pharmacological challenge with lithium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mailman, R B -- Krigman, M R -- Mueller, R A -- Mushak, P -- Breese, G R -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):637-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; *Drinking Behavior/drug effects ; Female ; Lead Poisoning/*physiopathology ; Lithium/pharmacology ; Male ; Rats ; Renin/blood
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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