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  • Chloride Channels/*metabolism  (1)
  • American Association for the Advancement of Science (AAAS)  (1)
  • American Institute of Physics (AIP)
  • Amsterdam : Elsevier
  • 2000-2004  (1)
  • American Association for the Advancement of Science (AAAS)  (1)
  • American Institute of Physics (AIP)
  • Amsterdam : Elsevier
  • 2000-2004  (1)
  • 1
    Publication Date: 2004-08-25
    Description: Intracellular acidification of skeletal muscles is commonly thought to contribute to muscle fatigue. However, intracellular acidosis also acts to preserve muscle excitability when muscles become depolarized, which occurs with working muscles. Here, we show that this process may be mediated by decreased chloride permeability, which enables action potentials to still be propagated along the internal network of tubules in a muscle fiber (the T system) despite muscle depolarization. These results implicate chloride ion channels in muscle function and emphasize that intracellular acidosis of muscle has protective effects during muscle fatigue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pedersen, Thomas H -- Nielsen, Ole B -- Lamb, Graham D -- Stephenson, D George -- New York, N.Y. -- Science. 2004 Aug 20;305(5687):1144-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of Aarhus, DK-8000, Denmark.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Calcium/metabolism ; Chloride Channels/*metabolism ; Chlorides/metabolism ; Electric Stimulation ; Hydrogen-Ion Concentration ; In Vitro Techniques ; Lactic Acid/metabolism ; Membrane Potentials ; Muscle Contraction ; *Muscle Fatigue ; Muscle Fibers, Skeletal/metabolism/*physiology ; Muscle, Skeletal/metabolism/*physiology ; Permeability ; Potassium/metabolism ; Rats ; Sarcoplasmic Reticulum/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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