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  • 1
    Call number: PIK P 113-07-0121
    Type of Medium: Monograph available for loan
    Pages: XXI,409 S. , graph. Darst.
    ISBN: 0910325189
    Note: Erscheinungsjahr in Vorlageform:c 2006
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 2
    Monograph available for loan
    Monograph available for loan
    Associated volumes
    Call number: 12201
    In: Abstract Journal in Earthquake Engineering
    Type of Medium: Monograph available for loan
    Pages: XI, 378 S.
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 3
    Monograph available for loan
    Monograph available for loan
    New York [u.a.] : Wiley
    Call number: AWI G7-93-0181/1 ; AWI G7-93-0181/2
    Description / Table of Contents: Contents: Chapter 1 Late Weichselian lce Sheets in Eurasia and Greenland / Bjöm G. Andersen. - NORTHERN EUROPE. - Holland. - Germany. - Denmark. - Sweden. - Finland. - Poland. - Western USSR (including Baltic SSR). - Northwestern USSR. - Norway. - North Sea. - British Isles. - lceland. - SOUTHERN EUROPE. - BARENTS SEA AND ARCTIC ISLANDS. - ASIA. - GREENLAND. - REFERENCES CITED. - Chapter 2 Late Wisconsin Ice Sheets of North America / Paul A. Mayewski, George H. Denton, Terence J. Hughes. - INTRODUCTION. - LAURENTIDE ICE SHEET. - Eastern Sector. - Southern Sector. - Western Sector. - Northern Sector. - Northeastern Sector. - Interior Sector. - QUEEN ELIZABETH ISLANDS. - Late Wisconsin Maximum. - Late Wisconsin Recession. - CORDILLERAN ICE SHEET. - Late Wisconsin Maximum. - Late Wisconsin Recession. - NORTH AMERICAN ICE SHEETS: AN OVERVIEW . - Maximum and Minimum. - Reconstructions. - Fundamental Questions About Late Wisconsin Deglaciation. - Glaciological Speculations. - REFERENCES CITED. - APPENDIX. - Chapter 3 Late Wisconsin-Weichselian Mountain Glaciers and Small Ice Caps / John T. Hollin, David H. Schiling. - INTRODUCTION. - ALASKA. - WESTERN UNITED STATES. - MEXICO AND CENTRAL AMERICA. - SOUTH AMERICA. - Venezuela. - Colombia. - Ecuador. - Peru. - Bolivia. - Chile and Argentina to Lat 36°30'S. - Chile and Argentina South of Lat 36°30'S. - Islas Juan Fernandez. - Falkland Islands (Islas Malvinas). - Brazil. - Areas and Volumes. - NEWZEALAND. - AUSTRALIA, NEW GUINEA, AND SABAH. - The Australian Mainland. - Tasmania. - New Guinea and Sabah. - Conclusions. - AFRICA. - Northwest Africa and Atlantic Islands. - Mountains in Ethiopia. - Mountains Surrounding Lake Victoria. - South and West Africa. - SUBANTARCTIC ISLANDS. - CONCLUSIONS. - REFERENCES CITED. - Chapter 4 Numerical Reconstruction of Valley Glaciers and Small Ice Caps / David H. Schilling, John T. Hollin. - INTRODUCTION. - VALLEY GLACIERS AND PERFECT PLASTICITY. - The Iterative Scheme. - The Shape Factor. - Choice of the Yield Stress. - Choice of Step Length, [Delta x]. - The First Step and the Snout. - Steep and Mountainous Areas. - The VALLEY Program. - ICE CAPS, WITH SLIDING AND ABLATION. - Perfect Plasticity. - Law of Sliding and Iterative Scheme. - The ABLATE Program. - Various Models and the Flow Law. - An Application of the ABLATE Program. - Some Remaining Problems. - CONCLUSIONS. - REFERENCES CITED. - Chapter 5 Numerical Reconstruction of Paleo-Ice Sheets / Terence J. Hughes. - ICE-BED COUPLING AND SUBGLACIAL HYDROLOGY. - SUBGLACIAL HYDROLOGY AND EROSION-DEPOSITION PROCESSES. - TOPOGRAPHIC CRITERIA FOR RECONSTRUCTING FORMER ICE SHEETS. - Subglacial Landscapes. - Ice Domes. - Ice Saddles. - Melting Zone. - Equilibrium Zone. - Freezing Zone. - Ice Streams. - BASIC EQUATIONS FOR STEADY-STATE CREEP IN ICE SHEETS. - BASAL SHEAR STRESS AND TWO-DIMENSIONAL LAMINAR FLOW. - BASAL SHEAR STRESS AND BASAL SLIDING. - BASAL SHEAR STRESS AND CONSTRUCTING ICE-SHEET PROFILES. - BASAL SHEAR STRESS FOR FROZEN AND MELTED BEDS. - BASAL SHEAR STRESS FOR FREEZING AND MELTING BEDS. - BASAL SHEAR STRESS FOR ICE STREAMS AND ICE LOBES. - BASAL SHEAR STRESS FOR ICE DIVIDES. - EVALUATING TERMS IN THE FLOW AND SLIDING LAWS FOR GLACIAL ICE. - RADIAL FLOW AND SNOW ACCUMULATION FOR ICE DOMES. - LATERAL SHEAR AND DOWNDRAW FOR ICE STREAMS. - ISOSTATIC ADJUSTMENTS BENEATH ICE SHEETS. - SUMMARY. - REFERENCES CITED. - Chapter 6 The Last Great Ice Sheets: A Global View / Terence J. Hughes, George H. Denton, Björn G. Andersen, David H. Schilling, James L. Fastook, Craig S. Lingle. - AREAL EXTENT OF LATE WISCONSIN-WEICHSELIAN ICE SHEETS. - North America. - Greenland. - Eurasia. - Antarctica. - Minimum and Maximum. - Reconstructions of Late Wisconsin-Weichselian Ice Extent. - VERTICAL EXTENT OF LATE WISCONSIN-WEICHSELIAN ICE SHEETS. - The Critical Problem of Marine Ice Sheets. - Flowline Profiles for Variable Bed Topography. - Flowline Profiles for Variable Isostatic Compensation. - Flowline Profiles for Variable Basal Shear Stress. - Flowline Profiles for Present-day Ice Sheets. - Flowline Profiles for Late Wisconsin-Weichselian Ice Sheets. - Isostatic Conditions for Late Wisconsin-Weichselian Ice Sheets. - Basal Conditions for Late Wisconsin-Weichselian Ice Sheets. - Elevations and Volumes of Late Wisconsin-Weichselian Ice Sheets. - DISCUSSION. - REFERENCES CITED. - Chapter 7 History of the Marine Ice Sheet In West Antarctica During the Last Glaciation: A Working Hypothesis / Minze Stuiver, George H. Denton, Terence J. Hughes, James L. Fastook. - INTRODUCTION . - McMURDO SOUND AREA. - Ross Sea Drift: Description. - Ross Sea Drift: Interpretation. - Radiometric Dates and Ross Sea Drift. - Older Drift: Description and Interpretation. - Discussion. - TERRA NOVA BAY. - BEAUFORT AND FRANKLIN ISLANDS. - GLACIAL-MARINE SEDIMENTS IN THE ROSS SEA. - RECONSTRUCTION OF LATE WISCONSIN ANTARCTIC ICE SHEET. - Geologic Background. - Glaciological Background: Steady-State Model. - Conclusions. - DISINTEGRATION OF MARINE ICE SHEET IN WEST ANTARCTICA. - Disintegration Model. - Disintegration of Ice Shelves. - Late Wisconsin-Holocene Disintegration. - Disintegration during Super Interglacials. - SUMMARY. - REFERENCES CITED. - Chapter 8 The Arctic Ice Sheet: An Outrageous Hypothesis / George H. Denton, T erence J. Hughes. - ICE-SHELF ORIGIN OF NORTHERN HEMISPHERE ICE DOMES. - Growth Rates of Arctic Ice Domes. - Sites for lnitiating Arctic Ice Domes. - Thickening Rates of Arctic Sea Ice. - Sites for Grounding Arctic Sea Ice. - Forming Arctic Ice Shelves on Deep Oceans. - Assessing the lce-Shelf Hypothesis for Forming Marine Ice Domes. - LA TE WISCONSIN-WEICHSELIAN ARCTIC ICE SHEET. - Ice Domes. - Ice Streams. - Ice Shelves. - DISINTEGRATION OF LATE WISCONSIN-WEICHSELIAN ARCTIC ICE SHEET. - Initiation of Late Wisconsin-Weichselian Glacial Surges. - Maintenance of Late Wisconsin-Weichselian Glacial Surges. - Environmental Impact of Late Wisconsin-Weichselian Glacial Surges. - CONCLUSIONS. - REFERENCES CITED. - INDEX.
    Type of Medium: Monograph available for loan
    Pages: XVIII, 484 S. : Ill., Kt. ; 27 Kt.-Beil.
    ISBN: 0471060062
    Series Statement: A Wiley interscience publication
    Location: AWI Reading room
    Location: AWI Reading room
    Branch Library: AWI Library
    Branch Library: AWI Library
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  • 4
    Call number: MOP Per 701/B(NF, 74, 1-12)
    In: Meteorologische Abhandlungen
    Type of Medium: Monograph available for loan
    Pages: Getr. Zählung
    Series Statement: Meteorologische Abhandlungen : Serie B, Grundlagenmaterial N. F., 74, 1-12
    Location: MOP - must be ordered
    Branch Library: GFZ Library
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  • 5
    Call number: MOP 35695
    In: NCAR technical notes
    Type of Medium: Monograph available for loan
    Pages: 142 S.
    Series Statement: NCAR technical notes 18
    Location: MOP - must be ordered
    Branch Library: GFZ Library
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  • 6
    Monograph available for loan
    Monograph available for loan
    Schweden
    Call number: AWI G5-02-0107
    Type of Medium: Monograph available for loan
    Pages: S. 139-432
    Series Statement: Geografiska Annaler Series A: Physical Geography 82A, 2000
    Branch Library: AWI Library
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  • 7
    Call number: AWI G5-99-0095
    In: Quaternary Research, Volume 3, Issue 2
    Type of Medium: Monograph available for loan
    Pages: Seite 155-205 , Illustrationen , 30 cm
    ISSN: 0033-5894 (Print) , 1096-0287 (Online)
    Series Statement: Quaternary Research 3,2
    Language: English
    Location: AWI Reading room
    Branch Library: AWI Library
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  • 8
    Monograph available for loan
    Monograph available for loan
    London ; New York : Taylor & Francis
    Call number: PIK B 160-03-0320
    Type of Medium: Monograph available for loan
    Pages: 256 p.
    Edition: 1. ed.
    ISBN: 0415192153
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 9
    Publication Date: 2011-12-22
    Print ISSN: 0031-9120
    Electronic ISSN: 1361-6552
    Topics: Physics
    Published by Institute of Physics
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  • 10
    Publication Date: 2024-04-01
    Description: In this study we interrogate 630 compounds of the Maybridge Rule of 3 Fragment Library for compounds that interact with, and inhibit TbCK. The Maybridge Rule of 3 Fragment Library is a small collection of quantifiable diverse, pharmacophoric rich, chemical entities that comply with the following criteria; MW ≤ 300, cLogP ≤ 3, H-Bond Acceptors ≤ 3, H-Bond Donors ≤ 3, Rotatable bonds (Flexibility Index) ≤ 3, Polar Surface Area ≤ 60 Å2 and aqueous solubility ≥ 1 mM using LogS and high purity (≥ 95%). Comparisons between two different screening methods, a coupled enzyme activity assay and differential scanning fluorimetry, has allowed identification of compounds that interact and inhibit the T. brucei choline kinase, several of which possess selective trypanocidal activity. Screening of a comparatively small fragment library by two different screening methods has allowed identification of several compounds that interact with and inhibit TbCK, a genetically validated drug target against African sleeping sickness. Some of the inhibitory fragments were also selectively trypanocidal, considering these are relatively simple molecules with no optimization, finding low μΜ inhibitors is very encouraging. Moreover some of the morphological phenotypes of these trypanocidal compounds include cell-cycle arrests similar to those observed for the TbCK conditional knockout grown under permissive conditions.
    Keywords: pharmacology ; toxicology ; pharmacology ; toxicology ; Assay ; Enzyme ; Molar concentration ; Protein ; Thermal shift assay ; Trypanosoma brucei ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
    Format: image/jpeg
    Format: image/jpeg
    Format: image/jpeg
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