Publication Date:
2011-01-12
Description:
Homologous recombination (HR) is a key pathway to repair complex DNA damage, such as DNA gaps, double-strand breaks, and interstrand cross-links (1) (Fig. 1). Moreover, HR supports the recovery of stalled or broken replication forks and ensures faithful chromosome segregation during meiosis. The RAD52 gene in the budding yeast Saccharomyces cerevisiae encodes the lynchpin of HR in this organism. Hence, the genes of the HR pathway are called the RAD52 epistasis group. However, much to everybody's surprise, the RAD52 gene knockout in mice exhibits minimal to no phenotypes in recombination, repair, and meiosis (2). Instead, the breast and ovarian tumor...
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General
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