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  • 11
    Electronic Resource
    Electronic Resource
    Dihydroergocryptine binding and α -adrenoreceptors in smooth muscle (1980)
    [s.l.] : Nature Publishing Group
    Nature 283 (1980), S. 108-109 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE recent letter by Kunos et al.1 in which they "dissociate phentolamine-suppressible 3H-dihydroergocryptine (3H-DHEC) binding and a-receptors" in rabbit myometrium disagrees with previous reports2'3 and contains several puzzling features. First, the authors assume that the concentrations of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/283108b0
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  • 12
    Electronic Resource
    Electronic Resource
    Tonic in vivo inhibition of rabbit myometrial adrenergic receptors (1981)
    [s.l.] : Nature Publishing Group
    Nature 292 (1981), S. 623-625 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Uteri from immature New Zealand rabbits (typically six rabbits per experiment) were pooled, the endometrium removed and myometrial strips divided equally into two groups. Myometrium in the first group was used immediately in isometric contraction studies or was homogenized and a particulate ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/292623a0
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  • 13
    Electronic Resource
    Electronic Resource
    α adrenoreceptors but not β adrenoreceptors increase in rabbit uterus with oestrogen (1977)
    [s.l.] : Nature Publishing Group
    Nature 270 (1977), S. 624-625 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] After injecting immature New Zealand rabbits intramuscularly with 150 Mg estradiol benzoate for 4 d, we prepared myometrial strips and examined isometric muscle contractility in vitro. Such strips exhibit spontaneous contractile activity, and contractions are increased in force and frequency when ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/270624a0
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  • 14
    Electronic Resource
    Electronic Resource
    Localization of β -adrenoreceptors in mammalian lung by light microscopic autoradiography (1982)
    [s.l.] : Nature Publishing Group
    Nature 299 (1982), S. 444-447 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The lung contains over 40 different cell types and, although radioligand binding assays show the density of @- receptors in whole lung homogenates to be higher than in any other tissue4'7, the localization of (3 -receptors in the lung has not been possible by assay alone. Previous attempts to study ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/299444a0
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  • 15
    Electronic Resource
    Electronic Resource
    Bared essentials of CDK2 and cyclin E (2003)
    [s.l.] : Nature Publishing Group
    Nature genetics 35 (2003), S. 8-9 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Oscillations in the activities of cyclin-dependent kinases (CDKs) dictate orderly progression through the cell division cycle. In the simplest case, a progressive rise in the activity of a single cyclin–CDK complex can initiate DNA synthesis and then mitosis, and the subsequent fall in CDK ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1234
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  • 16
    Electronic Resource
    Electronic Resource
    The murine gene p27 Kip1 is haplo-insufficient for tumour suppression (1998)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 396 (1998), S. 177-180 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] p27Kip is a candidate human tumour-suppressor protein, because it is able to inhibit cyclin-dependent kinases and block cell proliferation. Abnormally low levels of the p27 protein are frequently found in human carcinomas, and these low levels correlate directly with both ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/24179
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  • 17
    Electronic Resource
    Electronic Resource
    Association of cyclin A and cdk2 with SV40 DNA in replication initiation complexes is cell cycle dependent (1997)
    Springer
    Chromosoma 105 (1997), S. 349-359 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The cell cycle is driven by the sequential activation of a family of cyclin-dependent kinases (CDK) in association with cyclins. In mammalian cells the timing of activation of cyclin A-associated kinase activity coincides with the onset of DNA synthesis in S-phase. Using in vitro replication of SV40 origin-containing DNA as a model system, we have analyzed the proteins associated with DNA during initiation of DNA replication in S-phase cell extracts. This analysis reveals that, in addition to replication initiation proteins, cyclin A and cdk2 are also specifically associated with DNA. The association of cyclin A and cdk2 with DNA during initiation is cell cycle regulated and occurs specifically in the presence of SV40 origin-containing plasmid and SV40 T antigen (the viral replication initiator protein). The interactions among proteins involved in initiation play an important role in DNA replication. We therefore investigated the ability of cyclin A and cdk2 to associate with replication initiation proteins. Under replication initiation conditions, cyclin A and cdk2 from S-phase extracts specifically associate with SV40 T antigen. Further, the interaction of cyclin A-cdk2 with SV40 T antigen is mediated via cyclin A, and purified recombinant cyclin A associates directly with SV40 T antigen. Taken together, our results suggest that cyclin A and cdk2 are components of the SV40 replication initiation complex, and that protein-protein interactions between cyclin A-cdk2 and T antigen may facilitate the association of cyclin A-cdk2 with the complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004120050194
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  • 18
    Electronic Resource
    Electronic Resource
    Ammonia measurements at Niwot Ridge, Colorado and point arena, California using the tungsten oxide denuder tube technique (1988)
    Springer
    Journal of atmospheric chemistry 7 (1988), S. 137-152 
    Details
    ISSN: 1573-0662
    Keywords: Ammonia ; tungsten oxide ; tungstic acid ; tropospheric measurement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences
    Notes: Abstract The applicability of the tungsten oxide denuder tube technique for the measurement of ammonia in the rural troposphere was investigated. The technique is based on selective chemisorption of NH3 from a gas stream, thermal desorption, conversion to NO, and analysis by NO−O3 chemiluminescence. Nitric acid, which is also collected and desorbed as NO, was distinguished from NH3 by differences in desorption temperature. Substituted amines were also collected, but desorbed at a slightly lower temperature than NH3 in dry air. At high relative humidities, alkylamines may be hydrolyzed to NH3 on the denuder surface and hence detected as NH3. Overheating of the denuder tube during the temperature-programmed desorption was found to cause significant irreversible degradation of system performance. The technique was used to measure NH3 mixing ratios at two rural locations in the United States. At a mountain site in Colorado during the winter of 1984, the average NH3 mixing ratio was 0.20 ppbv (σ=0.08 ppbv). At an isolated coastal site in northern California during the spring of 1985, the average NH3 mixing ratio was 0.36 ppbv (σ=0.17 ppbv). Correlations of the latter measurements with wind direction and NO x level suggest that the NH3 mixing ratio in Pacific marine air at 40°N is 〈-0.25 ppbv.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00048043
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  • 19
    Electronic Resource
    Electronic Resource
    P57KIP2 targeted disruption and beckwith-wiedemann syndrome: Is the inhibitor just a contributor? (1997)
    New York, NY : Wiley-Blackwell
    BioEssays 19 (1997), S. 839-842 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Beckwith-Wiedemann syndrome is a human congenital disorder characterized by a wide variety of growth abnormalities, including developmental defects and predisposition to certain tumors. Genetic evidence has suggested a role for p57KIP2, a member of a family of cell cycle inhibitory genes, in Beckwith-Wiedemann syndrome. Two independent groups(1,2) have reported the generation and characterization of mice lacking functional p57KIP2, These mice demonstrate a number of abnormal phenotypes which overlap with, although do not completely recapitulate, Beckwith-Wiedemann syndrome. These findings advance the molecular characterization of a human disorder, and provide insight into the interplay between regulation of cell division and development.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950191002
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  • 20
    Electronic Resource
    Electronic Resource
    The thermal decomposition of peroxyacetic nitric anhydride (PAN) and peroxymethacrylic nitric anhydride (MPAN) (1992)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 24 (1992), S. 297-307 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The rate coefficients of thermal decomposition of peroxyacetic nitric anhydride (PAN) and peroxymethacrylic nitric anhydride (MPAN) were measured over the temperature range 302-323 K. The resulting Arrhenius expressions were k = 1017.4±0.4 exp(-28.5 ± 0.5/RT) for PAN, and k = 1016.2±0.7 exp(-26.8 ± 1.0/RT) for MPAN, where the activation energy is in Kcal/mol. These results are in good agreement with previous studies of PAN and other PAN-type compounds, and imply that energies of RC(O)OO—NO2 bonds are relatively independent of the nature of R.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550240307
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