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  • 11
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 12 (1980), S. 355-359 
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 28 (1987), S. 445-447 
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 5 (1974), S. 911-915 
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 25 (1986), S. 575-578 
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 25 (1986), S. 11-20 
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 2 (1971), S. 223-236 
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 10 (1979), S. 401-410 
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 19
    ISSN: 1437-3262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract A regional comparison of retrograde PTt paths of high pressure metamorphic terrains in the Scandinavian Caledonides (Seve Nappe Complex (S.N.C.)) and the French Massif Central (F.M.C.) reveals the following similarities: physical conditions of eclogite formation are roughly identical (600–780°C / 13.5–16.5 Kb), dominantly isothermal decompression. However in detail two major differences have been recognized: 1- In the S.N.C., PT estimates of eclogite formation are constant within individual tectonic lenses but vary when different tectonic lenses are compared. During uplift these temperature differences are maintained and diminish only at the final stages of the uplift history; 2- In the F.M.C. the physical conditions of eclogite formation are relatively constant (700–750°C/15Kb) but discrepancies in temperature (〉 100°C) appear during the first stages of the uplift history if one compares eastern with western domains. A thermal analytical model allows to explain these facts. In the S.N.C. the initial temperature difference during eclogite formation is related to various depths of burial. In the F.M.C. diachronic nappe stacking occurs implying a more pronounced screen effect in western than in eastern domains of the F.M.C. This also accounts for the initial retrogression under low- to middle amphibolite facies conditions in the west and granulite facies conditions in the east. Moreover from radiometric and structural data, we can see that all the uplift history of the S.N.C. is assisted by tectonic processes, while in the F.M.C., after the nappe pile was constructed, the uplift history is essentially controlled by erosional and/or isostatic processes.
    Abstract: Résumé La comparaison des évolutions rétromorphiques PTt des nappes de haute pression des Calédonides Scandinaves (Complexe des Nappes de Seve — S.N.C.) et du Massif Central français (F.M.C.) révèle les similarités suivantes: les conditions intensives du métamorphisme éclogitique sont très voisines (600–780°C/13.5–16.5 Kbar), suivi globalement d'une décompression isotherme. Cependant en détail, des différences majeures ont été reconnues: 1- Dans le S.N.C., les estimations PT de la formation des éclogites sont constantes au sein d'une même unité, mais varient quand cellesci sont comparées. Pendant la remontée, ces différences sont maintenues et ne diminuent que lors des stades terminaux; 2- Dans le F.M.C., les conditions intensives du métamorphisme de haute pression sont relativement homogènes (700–750°C/15 Kbar), mais des différences de température (〉 100°C) apparaissent pendant les premiers stades de la remontée entre les domaines occidentaux et orientaux. Une modélisation thermique de type analytique permet d'expliquer ces faits. Dans le S.N.C., la différence initiale de température pendant la formation des éclogites est liée à des profondeurs d'enfouissement variées. Dans le F.M.C., il existe un diachronisme lors de la mise en place des nappes, impliquant un effet d'écran plus prononcé à l'ouest qu'à l'est. Il rend également compte de la rétromorphose des assemblages de haute pression dans les conditions du faciès amphibolite à l'ouest et du faciès granulite à l'est du F.M.C. De plus, à partir des données radiométriques et structurales, on constate que l'ensemble de l'histoire de la remontée du S.N.C. est assistée par des processus tectoniques, alors que dans le F.M.C., une fois la pile tectonique constituée, sa remontée est essentiellement contrôlée par les mécanismes de l'érosion et ceux de l'isostasie.
    Notes: Zusammenfassung Ein regionaler Vergleich von PTt Pfaden von hochdruckbeanspruchten Gebieten in den skandinavischen Kaledoniden (Seve Nappe Complex (S.N.C.)) und dem französischen Zentralmassif (F.M.C.) zeigen folgende Ähnlichkeiten: Die physikalischen Bedingungen während der Eklogitbildung waren ungefähr identisch (600–780°C/ 13,5–16,5 kb), hauptsächlich isothermale Dekompression. Trotzdem werden zwei Hauptunterschiede beobachtet: 1- In den S.N.C. sind PT-Schätzungen der Eklogitbildung gleich in individuellen tektonischen Linsen; varriieren aber beim Vergleich verschiedener tektonischer Linsen. Während des Heraushebens wurden diese Temperaturunterschiede aufrechterhalten und verminderten sich nur in den letzten Stadien der Heraushebungsgeschichte. 2- In dem F.M.C. sind die physikalischen Bedingungen der Eklogitbildung relativ konstant (700–750°C/15 kb), aber es treten Temperaturdiskrepanzen (〉 100°C) während der ersten Heraushebungsstadien auf, wenn man die westlichen mit den östlichen Bereichen vergleicht. Ein thermales analytisches Modell erlaubt es diese Fakten zu erklären. In den S.N.C. ist die initiale Temperaturdifferenz während der Eklogitbildung mit verschiedenen Versenkungstiefen in Verbindung zu bringen. In dem F.M.C. erfolgte eine diachrone Deckenstapelung, dies bewirkte einen stärker betonten Abschirmeffekt in den westlichen Bereichen des F.M.C als in den östlichen. Der initiale Rückgang von niedriggradigen zu hochgradigen Amphibolitfaziesbedingungen im Westen und Granulitfaziesbedingungen im Osten legen hierüber Rechenschaft ab. Darüber hinaus können wir aus den radiometrischen und tektonischen Daten ersehen, daß die gesamte Hebungsgeschichte des S.N.C. von tektonischen Prozessen unterstützt wurde, während im F.M.C. die Hebungsgeschichte maßgeblich von erosiven und/oder isostatischen Prozessen kontrolliert wurde, nachdem die Dekkenstapelung beendet war.
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  • 20
    ISSN: 1432-0827
    Keywords: Key words: Osteoblast — Titanium — Fibronectin — Vitronectin — Roughness — Integrins.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. The influence of surface roughness and the presence of adhesion molecules in the culture medium were studied regarding cell adhesion, shape, and proliferation of osteoblast-like cells grown on two types of titanium disk. Type I disks were acid etched and type II disks were sandblasted and acid etched. Surface roughness was determined by contact profilometry and scanning electron microscopy. Chemical composition and oxide thickness of the superficial titanium layer were established with energy dispersive X-ray spectrometry, electron spectroscopy for chemical analysis and auger electron spectroscopy. Titanium release in the culture medium was assessed by inductively coupled plasma-optical emission spectrometry. Osteoblast-like cells (Saos-2) were cultured on both types of titanium disks (1) in standard conditions (DMEM culture medium supplemented with fetal calf serum), (FCS), (2) with the culture medium alone (DMEM alone), (3) in the presence of fibronectin or vitronectin (DMEM supplemented with fibronectin or vitronectin). Cultures were also performed in the presence of monoclonal anti-integrin (β1, αv) to test the cell adhesion molecules involved in the cell binding to the titanium surface. We found that sandblasting does not modify the chemical surface composition and that titanium represents only 5–6% (in the atom percentage) of surface elements. Release of titanium in the culture medium was found to increase from 24 to 72 hours. In the absence of FCS, fibronectin, or vitronectin, cells appeared scanty and packed in clusters. On the contrary, cells cultured in the presence of FCS, fibronectin, or vitronectin were flattened with large and thin cytoplasmic expansions. The addition of anti β1 or αv integrin subunit monoclonal antibody in the culture medium decreased adhesion and spreading of cells, particularly in the presence of fibronectin. Cell proliferation was significantly higher on culture plastic than on both types of disks, but was increased on rough but not on smooth surfaces. These results indicate that a high surface roughness and presence of fibronectin or vitronectin are critical elements for adhesion, spreading, and proliferation of cells on titanium surfaces.
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