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  • 11
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    Spacelab 1 hematology experiment (INS103): Influence of space flight on erythrokinetics in man (1985)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: An experiment conducted on the 10-day Spacelab 1 mission aboard the ninth Space Shuttle flight in November to December 1983 was designed to measure factors involved in the control of erythrocyte turnover that might be altered during weightlessness. Blood samples were collected before, during, and after the flight. Immediately after landing, red cell mass showed a mean decrease of 9.3 percent in the four astronauts. Neither hyperoxia nor an increase in blood phosphate was a cause of the decrease. Red cell survival time and iron incorporation postflight were not significantly different from their preflight levels. Serum haptoglobin did not decrease, indicating that intravascular hemolysis was not a major cause of red cell mass change. An increase in serum ferritin after the second day of flight may have been caused by red cell breakdown early in flight. Erythropoietin levels decreased during and after flight, but preflight levels were high and the decrease was not significant. The space flight-induced decrease in red cell mass may result from a failure of erythropoiesis to replace cells destroyed by the spleen soon after weightlessness is attained.
    Keywords: AEROSPACE MEDICINE
    Type: NASA-TM-58268 , S-548 , NAS 1.15:58268
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 12
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    Erythropoietic effects of space flight (1979)
    In:  Other Sources
    Details
    Publication Date: 2019-06-27
    Description: Various factors which are important in the regulation of erythropoiesis have been studied in dehydrated mice in the belief that some information would be gained relevant to the erythropoietic effects of space flight. Dehydration reduced the plasma volume and, because changes in red cell volume were minimal, the hematocrit was elevated. Thus a state of relative erythrocytosis was produced. Understanding of the mechanism whereby these changes decreased red cell production is uncertain and appears to differ somewhat from the erythroid suppression seen following elevation of the hematocrit in animals with an absolute erythrocytosis. It is suggested that factors outside of the normal erythropoietic control pathway (such as energy balance) may play an important role in the decrease in red cell volume seen in man following space flight.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: Acta Astronautica; 6; May-June
    Format: text
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    NASA TECHNICAL REPORTS
  • 13
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    Hematopoiesis in antiorthostatic, hypokinesic rats (1983)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: Rats exposed to antiorthostatic, hypokinesia showed the following effects which are comparable to those seen in man during or after space flight: weight loss, reduced food and water consumption, transient increases in peripheral hematocrit and RBC count, decreasing MCV and reduced reticulocyte count. In addition, the hemoglobin P50 was shifted to the right. A significant shortening of RBC t1/2 was only seen after suspension. Changes in leukocyte and platelet numbers in suspended rats were also comparable to those in man during space flight, but leukocyte PHA sensitivity in rats showed no consistent alteration. The results demonstrate that this model reproduces many of the hematological effects of space flight and has potential as a tool in understanding the hematopoietic response to zero gravity.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: Physiologist, Supplement (ISSN 0031-9376); 26; S-133
    Format: text
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    NASA TECHNICAL REPORTS
  • 14
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    Regulation of hematopoiesis in rats exposed to antiorthostatic hypokinetic/hypodynamia. II - Mechanisms of the 'anemia' (1986)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: The cause of the red cell mass (RCM) deficit, which occurs in rats during suspenion, is investigated. The experimental conditions and procedures, in which male Sprague-Dawley rats are subjected to antiorthostatic hyypokinetic/hypodynamia and changes in RCM are monitored, are described. The influences of stress, reduced food and water consumption, and antiorhostatic posture on RCM are analyzed. Changes in body weight, RCM, radioiron incorporation, red blood cells (RBC), and reticulocytes, for the rats after head-down suspension are graphically presented; only the changes in RBC are related to the antiorthostatic posture. The data reveal that anemia is primarily caused by reduced food and water consumption and secondly by restricted movements.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: Aviation, Space, and Environmental Medicine (ISSN 0095-6562); 57; 36-44
    Format: text
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