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  • 11
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    Fossil fuels: Peak oil is affecting the economy already (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-03-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, David J -- England -- Nature. 2012 Mar 28;483(7391):541. doi: 10.1038/483541a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22460887" target="_blank"〉PubMed〈/a〉
    Keywords: Environmental Policy/*legislation & jurisprudence ; Fossil Fuels/*economics/*supply & distribution
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 12
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    Deregulated MYC expression induces dependence upon AMPK-related kinase 5 (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-03-31
    Description: Deregulated expression of the MYC oncoprotein contributes to the genesis of many human tumours, yet strategies to exploit this for a rational tumour therapy are scarce. MYC promotes cell growth and proliferation, and alters cellular metabolism to enhance the provision of precursors for phospholipids and cellular macromolecules. Here we show in human and murine cell lines that oncogenic levels of MYC establish a dependence on AMPK-related kinase 5 (ARK5; also known as NUAK1) for maintaining metabolic homeostasis and for cell survival. ARK5 is an upstream regulator of AMPK and limits protein synthesis via inhibition of the mammalian target of rapamycin 1 (mTORC1) signalling pathway. ARK5 also maintains expression of mitochondrial respiratory chain complexes and respiratory capacity, which is required for efficient glutamine metabolism. Inhibition of ARK5 leads to a collapse of cellular ATP levels in cells expressing deregulated MYC, inducing multiple pro-apoptotic responses as a secondary consequence. Depletion of ARK5 prolongs survival in MYC-driven mouse models of hepatocellular carcinoma, demonstrating that targeting cellular energy homeostasis is a valid therapeutic strategy to eliminate tumour cells that express deregulated MYC.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Lidan -- Ulbrich, Jannes -- Muller, Judith -- Wustefeld, Torsten -- Aeberhard, Lukas -- Kress, Theresia R -- Muthalagu, Nathiya -- Rycak, Lukas -- Rudalska, Ramona -- Moll, Roland -- Kempa, Stefan -- Zender, Lars -- Eilers, Martin -- Murphy, Daniel J -- England -- Nature. 2012 Mar 28;483(7391):608-12. doi: 10.1038/nature10927.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Theodor Boveri Institute, Biocenter, University of Wurzburg, Am Hubland, 97074 Wurzburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22460906" target="_blank"〉PubMed〈/a〉
    Keywords: AMP-Activated Protein Kinases/metabolism ; Adenosine Triphosphate/metabolism ; Animals ; Apoptosis ; Carcinoma, Hepatocellular/drug therapy/genetics/metabolism/pathology ; Cell Line, Tumor ; Cell Respiration ; Cell Survival ; Cell Transformation, Neoplastic/genetics ; Disease Models, Animal ; Doxycycline/pharmacology ; Electron Transport ; *Gene Expression Regulation, Neoplastic ; Genes, myc/*genetics ; Glutamine/metabolism ; Homeostasis ; Humans ; Liver Neoplasms/drug therapy/genetics/metabolism/pathology ; Mice ; Mitochondria/metabolism ; Multiprotein Complexes ; Oncogene Protein p55(v-myc)/genetics/metabolism ; Protein Biosynthesis ; Protein Kinases/deficiency/genetics/*metabolism ; Proteins/antagonists & inhibitors/metabolism ; RNA Interference ; Repressor Proteins/antagonists & inhibitors/deficiency/genetics/*metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 13
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    A climatological study of short-period gravity waves and ripples at Davis Station, Antarctica (68 °S, 78 °E) during the (austral winter February-October) period 1999-2013 (2017)
    Wiley
    Details
    Publication Date: 2017-10-15
    Description: A scanning radiometer deployed at Davis Station, Antarctica (68 ° S, 78 ° E) has been recording infrared (1.10-1.65 μm) images of a small region (24 km × 24 km) of the zenith night sky once per minute each austral winter night since February 1999. These images have been processed to extract information on the passage of gravity waves (GWs) (horizontal wavelength, λ h 〉 15 km) and ripples ( λ h ≤ 15 km) over the observing station. Phase speeds, periods, horizontal wavelengths, and predominant propagation directions have been deduced. Observed speeds were found to be highly correlated with horizontal wavelengths as has been reported in previous studies. Reverse ray-tracing of the detected GWs only enabled us to identify four distinct groups. On average only 15% of waves detected can be traced back to the troposphere, and a large proportion ( ~ 45%) were not successfully reverse traced substantially below the airglow layer. Two smaller groups were found to reach a termination condition for reverse ray-tracing at altitudes near 50 km and 75 km. Of those that reached the termination altitude in the troposphere (10 km), most of the end points fell within a radius of 300 km of the station, with a very pronounced concentration of wave initiation to the north west at approximately of the observing point. The predominant direction of propagation was southward, and they were observed throughout the year. Recent reports suggest the interaction of planetary waves with the background wind field as a potential source for these waves.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 14
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    Domain wall fermion QCD with the exact one flavor algorithm (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-03-14
    Description: Author(s): C. Jung, C. Kelly, R. D. Mawhinney, and D. J. Murphy Lattice QCD calculations including the effects of one or more nondegenerate sea quark flavors are conventionally performed using the rational hybrid Monte Carlo (RHMC) algorithm, which computes the square root of the determinant of D † D , where D is the Dirac operator. The special case of two degenera... [Phys. Rev. D 97, 054503] Published Tue Mar 13, 2018
    Keywords: Lattice field theories, lattice QCD
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 15
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    cisExpress: motif detection in DNA sequences (2013)
    Oxford University Press
    Details
    Publication Date: 2013-08-13
    Description: Motivation: One of the major challenges for contemporary bioinformatics is the analysis and accurate annotation of genomic datasets to enable extraction of useful information about the functional role of DNA sequences. This article describes a novel genome-wide statistical approach to the detection of specific DNA sequence motifs based on similarities between the promoters of similarly expressed genes. This new tool, cisExpress , is especially designed for use with large datasets, such as those generated by publicly accessible whole genome and transcriptome projects. cisExpress uses a task farming algorithm to exploit all available computational cores within a shared memory node. We demonstrate the robust nature and validity of the proposed method. It is applicable for use with a wide range of genomic databases for any species of interest. Availability: cisExpress is available at www.cisexpress.org . Contact: tatiana.tatarinova@usc.edu Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 16
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    Trends and Variability in Vertical Winds in the Southern Hemisphere Summer Polar Mesosphere and Lower Thermosphere (2019)
    Wiley
    Details
    Publication Date: 2019
    Description: Abstract Direct measurement of mean vertical velocities in the mesosphere‐lower thermosphere (60–110 km) is not possible due to their small values. Here we derive vertical velocities using the divergence of the mean meridional wind over the Antarctic summer pole using MF radar wind measurements made at Davis Station (69°S, 78°E) between 1994 and 2018. Estimates of vertical velocity are restricted to a 21‐day period centered just after solstice when the equatorward wind reaches its maximum value of about 15 m s−1 at heights near 90 km. The Medium Frequency (MF) radar winds are calibrated against colocated meteor wind radar observations. Neutral densities required for the vertical wind calculations are obtained from zonally averaged temperature measurements obtained by the MLS instrument aboard the AURA satellite. The estimated vertical velocities have peak values varying between 2 and 6 cm s−1 with significant interannual variability. While the peak values do not show significant long‐term change, there is a long‐term decrease in the mean height of maximum winds of about 0.6 km per decade that is statistically significant. The interannual variability is linked to the date of transition in the stratospheric zonal circulation from winter eastward to summer westward flow. Meridional and vertical velocities are smaller and peak at lower altitudes during early transitions (20–30 days prior to solstice) than is the case for late transitions that occur at solstice or later.
    Print ISSN: 2169-897X
    Electronic ISSN: 2169-8996
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 17
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    Tides in the mesopause region over Antarctica: Comparison of Whole Atmosphere Model (WAM) simulations with ground-based observations (2016)
    Wiley
    Details
    Publication Date: 2016-01-09
    Description: Almost a quarter century ago first optical and radar observations from the South Pole revealed rich dynamics unexpected from classical tidal theory. A strong semidiurnal wind oscillation was detected near the mesopause implying substantial deviations from the classical view that the semidiurnal variation is dominated by the migrating tide. Subsequent systematic observations exhibited large seasonal variations of both the diurnal and semidiurnal tide with dramatic reduction in amplitude from summer to winter. First numerical simulations with a realistic general circulation model extending into the lower thermosphere indicated the presence of nonmigrating tides with substantial amplitudes in the polar regions. However, direct model-data comparisons have been limited to idealized linear models. Here Whole Atmosphere Model (WAM) simulations for January and July are compared with available wind climatologies based on multi-year radar observations at different locations in Antarctica as well as with first summertime lidar measurements of temperature. The diurnal tide simulation agrees well with most of the independent radar and satellite wind observations in both seasons. The strong semidiurnal tide comprised of migrating and nonmigrating components is well reproduced in summer, while in winter the model tends to overestimate the amplitudes over the continental edge. Besides model validation, a self-consistent numerical solution also enables cross-validation of observations made with different instruments at different locales.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 18
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    Observations and fine-scale model simulations of gravity waves over Davis, East Antarctica (69∘S, 78∘E) (2017)
    Wiley
    Details
    Publication Date: 2017-06-30
    Description: Large vertical velocities were observed throughout the troposphere at Davis, East Antarctica on 18 February 2014 by a VHF wind-profiling radar. Simulations using the Met Office Unified Model at 2.2, 0.5, and 0.1 km horizontal grid spacing were able to broadly capture the location, timing, and magnitude of the observed velocities, as well as reveal that they are due to small-scale orographic gravity waves resulting from the interaction between the coastal topography and strong easterly winds associated with a synoptic-scale cyclone situated to the north. The simulations indicated that the gravity waves are responsible for: i) temperature fluctuations which coincided with satellite-observed cloud variations in the vicinity of Davis, suggesting that they have a crucial role in the formation of cirrus clouds, and ii) large vertical momentum fluxes in the troposphere. The waves are prevented from propagating into the stratosphere by the background winds turning from near-surface easterlies to lower-stratospheric northerlies. As well as illuminating and quantifying the role that weather systems have in producing orographic gravity waves along the East Antarctic coastline, studies such as this should be exploited to improve the representation of key localised atmospheric processes in global climate models.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 19
    Electronic Resource
    Electronic Resource
    Freezing Resistance in Intertidal Invertebrates (1983)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 45 (1983), S. 289-299 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ph.45.030183.001445
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  • 20
    Electronic Resource
    Electronic Resource
    EFFECTS OF PRE-MOULDED WOVEN CFRP PATCHES ON FATIGUE CRACK GROWTH AND RESIDUAL STRENGTH IN 7475-T761 ALUMINIUM ALLOY SHEET (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 7 (1984), S. 0 
    Details
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Fatigue crack propagation tests have been made on 150 mm wide panels of 1.6 mm thick 7475-T761 clad aluminium alloy sheet with and without adhesively bonded patches of pre-formed carbon fibre reinforced plastic (CFRP). The test frequency was 10 Hz, the minimum stress: maximum stress ratio, R, was 0.1 and the peak applied fatigue stress was 60 MPa.The tests were undertaken to assess the possibility of preventing the growth of fatigue cracks, or reducing their rate of growth, by the application of CFRP patches to one face only of pre-cracked aluminium alloy sheet. The variables examined included the type of patch and adhesive; the size, shape and thickness of the patch; and the effect of chamfering the edges of the patch and the removal of the cladding prior to patching.Results indicated that correctly designed and bonded CFRP patches substantially decreased the subsequent crack growth rate. The size and thickness of the patch had significant effects upon the reduction of fatigue crack growth rate whereas the shape of the patch, chamfering and the removal of the cladding prior to patching had little influence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-2695.1984.tb00200.x
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