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  • 11
    Publication Date: 2015-02-18
    Description: We use GNSS observations in northeastern Venezuela to constrain the El Pilar Fault (EPF) kinematics and to explore the effects of the variable elastic properties of the surrounding medium and of the fault geometry on inferred slip rates and locking depth. The velocity field exhibits an asymmetric velocity gradient on either side of the EPF. We use five different approaches to explore possible models to explain this asymmetry. First, we infer a 1.6-km locking depth using a classic elastic half-space dislocation model. Second, we infer a 1.5-km locking depth and a 0.33 asymmetry coefficient using a heterogeneous asymmetric model, including contrasting material properties on either side of a vertical fault, suggesting that the igneous-metamorphic terranes on the northern side are ~2 times more rigid than the sedimentary southern side. Third, we use a three-dimensional elasto-static model to evaluate the presence of a compliant zone (CZ), suggesting a 30% reduction of rigidity in the upper 3 km at the depth of a 1- to 5-km wide fault zone. Fourth, we evaluate the distribution of fault slip, revealing a widespread partial-creep pattern in the eastern upper segment, while the upper western segment exhibits a partially locked area, which coincides with the rupture surface of the 1797 and 1929 earthquakes. To supplement these models, we upgrade the previously published displacement simulation method using non-vertical dislocations with data acquired between 2003 and 2013. The localized aseismic displacement pattern associated with creeping or partially creeping fault segments could explain the low level of historic seismicity.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 12
    Publication Date: 2011-02-16
    Description: Sensory and signaling pathways are exquisitely organized in primary cilia. Bardet-Biedl syndrome (BBS) patients have compromised cilia and signaling. BBS proteins form the BBSome, which binds Rabin8, a guanine nucleotide exchange factor (GEF) activating the Rab8 GTPase, required for ciliary assembly. We now describe serum-regulated upstream vesicular transport events leading to centrosomal Rab8 activation and ciliary membrane formation. Using live microscopy imaging, we show that upon serum withdrawal Rab8 is observed to assemble the ciliary membrane in ∼100 min. Rab8-dependent ciliary assembly is initiated by the relocalization of Rabin8 to Rab11-positive vesicles that are transported to the centrosome. After ciliogenesis, Rab8 ciliary transport is strongly reduced, and this reduction appears to be associated with decreased Rabin8 centrosomal accumulation. Rab11-GTP associates with the Rabin8 COOH-terminal region and is required for Rabin8 preciliary membrane trafficking to the centrosome and for ciliogenesis. Using zebrafish as a model organism, we show that Rabin8 and Rab11 are associated with the BBS pathway. Finally, using tandem affinity purification and mass spectrometry, we determined that the transport protein particle (TRAPP) II complex associates with the Rabin8 NH2-terminal domain and show that TRAPP II subunits colocalize with centrosomal Rabin8 and are required for Rabin8 preciliary targeting and ciliogenesis.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 13
    Publication Date: 2019
    Description: 〈p〉We report a device that provides coherent emission of phonon polaritons, a mixed state between photons and optical phonons in an ionic crystal. An electrically pumped GaInAs/AlInAs quantum cascade structure provides intersubband gain into the polariton mode at = 26.3 μm, allowing self-oscillations close to the longitudinal optical phonon energy of AlAs. Because of the large computed phonon fraction of the polariton of 65%, the emission appears directly on a Raman spectrum measurement, exhibiting a Stokes and anti-Stokes component with the expected shift of 48 meV.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 14
    Publication Date: 2012-03-29
    Description: Author(s): D. Lebhertz, S. Courtin, F. Haas, D. G. Jenkins, C. Simenel, M.-D. Salsac, D. A. Hutcheon, C. Beck, J. Cseh, J. Darai, C. Davis, R. G. Glover, A. Goasduff, P. E. Kent, G. Levai, P. L. Marley, A. Michalon, J. E. Pearson, M. Rousseau, N. Rowley, and C. Ruiz The heavy-ion radiative capture reaction 12 C( 16 O, γ ) 28 Si has been studied at three energies E c.m. =8.5 , 8.8, and 9 MeV which are close to the Coulomb barrier. The weak radiative capture process has been identified by measuring the 28 Si recoils in the highly selective 0 ∘ spectrometer DRAGON at TRIUMF (... [Phys. Rev. C 85, 034333] Published Wed Mar 28, 2012
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
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  • 15
    Publication Date: 2014-10-08
    Description: Hepatitis B virus (HBV), the causative agent of chronic hepatitis B and prototypic hepadnavirus, is a small DNA virus that replicates by protein-primed reverse transcription. The product is a 3-kb relaxed circular DNA (RC-DNA) in which one strand is linked to the viral polymerase (P protein) through a tyrosyl–DNA phosphodiester...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 16
    Publication Date: 1999-04-02
    Description: Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tendon, muscle, and marrow stroma. Cells that have the characteristics of human mesenchymal stem cells were isolated from marrow aspirates of volunteer donors. These cells displayed a stable phenotype and remained as a monolayer in vitro. These adult stem cells could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages. Individual stem cells were identified that, when expanded to colonies, retained their multilineage potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pittenger, M F -- Mackay, A M -- Beck, S C -- Jaiswal, R K -- Douglas, R -- Mosca, J D -- Moorman, M A -- Simonetti, D W -- Craig, S -- Marshak, D R -- New York, N.Y. -- Science. 1999 Apr 2;284(5411):143-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043, USA. mpittenger@osiristx.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10102814" target="_blank"〉PubMed〈/a〉
    Keywords: Adipocytes/*cytology ; Adult ; Apoptosis ; Bone Marrow Cells/cytology ; Cell Differentiation ; Cell Division ; *Cell Lineage ; Cell Separation ; Cells, Cultured ; Chondrocytes/*cytology ; Fibroblasts/cytology ; Flow Cytometry ; Humans ; Mesoderm/*cytology ; Middle Aged ; Osteocytes/*cytology ; Phenotype ; Stem Cells/*cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 17
    Publication Date: 2012-03-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beck, Christopher -- Klemow, Kenneth -- Paulson, Jerome -- Bernstein, Aaron -- Lam, Mimi -- Middendorf, George -- Reynolds, Julie -- Belanger, Kenneth -- Cardelus, Catherine -- Cid, Carmen -- Doshi, Samir -- Gerardo, Nicole -- Jablonski, Leanne -- Kimmel, Heather -- Lowman, Margaret -- Macrae-Crerar, Aurora -- Pohlad, Bob -- de Roode, Jacobus -- Thomas, Carolyn -- New York, N.Y. -- Science. 2012 Mar 16;335(6074):1301. doi: 10.1126/science.335.6074.1301-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22422958" target="_blank"〉PubMed〈/a〉
    Keywords: *Curriculum ; *Education, Premedical ; *Educational Status ; *School Admission Criteria ; *Schools, Medical
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
    Publication Date: 2018-05-19
    Description: The Journal of Organic Chemistry DOI: 10.1021/acs.joc.8b00728
    Print ISSN: 0022-3263
    Electronic ISSN: 1520-6904
    Topics: Chemistry and Pharmacology
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  • 19
    Publication Date: 2015-03-20
    Description: Gas clouds in present-day galaxies are inefficient at forming stars. Low star-formation efficiency is a critical parameter in galaxy evolution: it is why stars are still forming nearly 14 billion years after the Big Bang and why star clusters generally do not survive their births, instead dispersing to form galactic disks or bulges. Yet the existence of ancient massive bound star clusters (globular clusters) in the Milky Way suggests that efficiencies were higher when they formed ten billion years ago. A local dwarf galaxy, NGC 5253, has a young star cluster that provides an example of highly efficient star formation. Here we report the detection of the J = 3--〉2 rotational transition of CO at the location of the massive cluster. The gas cloud is hot, dense, quiescent and extremely dusty. Its gas-to-dust ratio is lower than the Galactic value, which we attribute to dust enrichment by the embedded star cluster. Its star-formation efficiency exceeds 50 per cent, tenfold that of clouds in the Milky Way. We suggest that high efficiency results from the force-feeding of star formation by a streamer of gas falling into the galaxy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Turner, J L -- Beck, S C -- Benford, D J -- Consiglio, S M -- Ho, P T P -- Kovacs, A -- Meier, D S -- Zhao, J-H -- England -- Nature. 2015 Mar 19;519(7543):331-3. doi: 10.1038/nature14218.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics and Astronomy, University of California, Los Angeles, Los Angeles, California 90095-1547, USA. ; Department of Physics and Astronomy, University of Tel Aviv, 69978 Ramat Aviv, Israel. ; Observational Cosmology Laboratory, Code 665, NASA at Goddard Space Flight Center, Greenbelt, Maryland 20771, USA. ; Academia Sinica, Astronomy and Astrophysics, 11F Astronomy-Mathematics Building, AS/NTU No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan. ; Department of Physics, Caltech, Pasadena, California 91125, USA; Institute for Astrophysics, University of Minnesota, Minneapolis, Minnesota 55405, USA. ; 1] Department of Physics, New Mexico Institute of Mining and Technology, Socorro, New Mexico 85723, USA [2] National Radio Astronomy Observatory, 1003 Lopezville Road, Socorro, New Mexico 85723, USA. ; Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, Massachusetts 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25788096" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 20
    Publication Date: 2016-09-08
    Description: Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system Nature 537, 7619 (2016). doi:10.1038/nature19334 Authors: Sung Hoon Cho, Ariel L. Raybuck, Kristy Stengel, Mei Wei, Thomas C. Beck, Emmanuel Volanakis, James W. Thomas, Scott Hiebert, Volker H. Haase & Mark R. Boothby Germinal centres (GCs) promote humoral immunity and vaccine efficacy. In GCs, antigen-activated B cells proliferate, express high-affinity antibodies, promote antibody class switching, and yield B cell memory. Whereas the cytokine milieu has long been known to regulate effector functions that include the choice of immunoglobulin class, both cell-autonomous and extrinsic metabolic programming have emerged as modulators of T-cell-mediated immunity. Here we show in mice that GC light zones are hypoxic, and that low oxygen tension () alters B cell physiology and function. In addition to reduced proliferation and increased B cell death, low impairs antibody class switching to the pro-inflammatory IgG2c antibody isotype by limiting the expression of activation-induced cytosine deaminase (AID). Hypoxia induces HIF transcription factors by restricting the activity of prolyl hydroxyl dioxygenase enzymes, which hydroxylate HIF-1α and HIF-2α to destabilize HIF by binding the von Hippel–Landau tumour suppressor protein (pVHL). B-cell-specific depletion of pVHL leads to constitutive HIF stabilization, decreases antigen-specific GC B cells and undermines the generation of high-affinity IgG, switching to IgG2c, early memory B cells, and recall antibody responses. HIF induction can reprogram metabolic and growth factor gene expression. Sustained hypoxia or HIF induction by pVHL deficiency inhibits mTOR complex 1 (mTORC1) activity in B lymphoblasts, and mTORC1-haploinsufficient B cells have reduced clonal expansion, AID expression, and capacities to yield IgG2c and high-affinity antibodies. Thus, the normal physiology of GCs involves regional variegation of hypoxia, and HIF-dependent oxygen sensing regulates vital functions of B cells. We propose that the restriction of oxygen in lymphoid organs, which can be altered in pathophysiological states, modulates humoral immunity.
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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