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  • Articles  (205)
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  • 11
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    MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-12-20
    Description: Multivalent molecules with repetitive structures including bacterial capsular polysaccharides and viral capsids elicit antibody responses through B cell receptor (BCR) crosslinking in the absence of T cell help. We report that immunization with these T cell-independent type 2 (TI-2) antigens causes up-regulation of endogenous retrovirus (ERV) RNAs in antigen-specific mouse B cells. These RNAs are detected via a mitochondrial antiviral signaling protein (MAVS)-dependent RNA sensing pathway or reverse-transcribed and detected via the cGAS-cGAMP-STING pathway, triggering a second, sustained wave of signaling that promotes specific immunoglobulin M production. Deficiency of both MAVS and cGAS, or treatment of MAVS-deficient mice with reverse transcriptase inhibitors, dramatically inhibits TI-2 antibody responses. These findings suggest that ERV and two innate sensing pathways that detect them are integral components of the TI-2 B cell signaling apparatus.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391621/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391621/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zeng, Ming -- Hu, Zeping -- Shi, Xiaolei -- Li, Xiaohong -- Zhan, Xiaoming -- Li, Xiao-Dong -- Wang, Jianhui -- Choi, Jin Huk -- Wang, Kuan-wen -- Purrington, Tiana -- Tang, Miao -- Fina, Maggy -- DeBerardinis, Ralph J -- Moresco, Eva Marie Y -- Pedersen, Gabriel -- McInerney, Gerald M -- Karlsson Hedestam, Gunilla B -- Chen, Zhijian J -- Beutler, Bruce -- P01 AI070167/AI/NIAID NIH HHS/ -- R01 AI093967/AI/NIAID NIH HHS/ -- R01 CA157996/CA/NCI NIH HHS/ -- U19 AI100627/AI/NIAID NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2014 Dec 19;346(6216):1486-92. doi: 10.1126/science.346.6216.1486.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8502, USA. ; Department of Pediatrics and Children's Medical Center Research Institute, and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8502, USA. ; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8502, USA. Howard Hughes Medical Institute, Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9148, USA. ; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels vag 16, SE-171 77 Stockholm, Sweden. ; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8502, USA. Bruce.Beutler@UTSouthwestern.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25525240" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing/genetics/*immunology ; Animals ; Antibody Formation ; Antigens, T-Independent/*immunology ; B-Lymphocytes/*immunology ; Cytosol/immunology ; DNA/immunology ; Endogenous Retroviruses/genetics/*immunology ; Lymphocyte Activation ; Membrane Proteins/immunology ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Nucleotides, Cyclic/immunology ; Nucleotidyltransferases/genetics/*immunology ; RNA, Viral/genetics/*immunology ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 12
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    U-Pb Geochronology of Hydrothermal Zircons from the Early Cretaceous Iron Skarn Deposits in the Handan-Xingtai District, North China Craton (2015)
    Society of Economic Geologists (SEG)
    Details
    Publication Date: 2015-11-10
    Description: The Handan-Xingtai district in the North China craton is one of the most important concentrations of iron skarn deposits in China, with proven reserves of 900 to 1,000 Mt at an average of 40 to 55 wt % Fe. The iron mineralization occurs predominantly along contact zones between Early Cretaceous intermediate-silicic intrusions and Middle Ordovician marine carbonates intercalated with numerous evaporite beds. In this paper, we present textural features and laser ablation ICP-MS U-Pb dating results of hydrothermal zircon from five major iron skarn deposits to place tight constraints on the timing and duration of the district-scale iron mineralization. Zircon grains from the mineralized skarns are anhedral to subhedral crystals and euhedral tetragonal bipyramids. They are closely intergrown or texturally associated with diopside, garnet, epidote, calcite, albite, and phlogopite. Other common minerals in the skarn assemblages include F-rich hornblende, wilkeite-F, F-apatite, and fluorite. Zircon grains typically contain abundant inclusions of skarn minerals and daughter mineral-rich (mostly magnetite, halite, and sylvite) fluid inclusions. Compositionally, these zircon grains have moderately to extremely high Th (518–7,477 ppm) and U (109–25,610 ppm) contents, with highly variable Th/U ratios ranging from 0.01 to 5.23. The morphological, textural, and geochemical features of the zircons confirm their hydrothermal origin and indicate that they most likely precipitated from high-temperature, F-rich, magmatic-derived ore-forming fluids. The hydrothermal zircon grains yield well-defined concordant U-Pb ages for the five studied iron skarn deposits, with weighted mean 206 Pb/ 238 U dates ranging from 133.6 ± 0.9 to 128.5 ± 1.4 Ma (2 ). These ages are remarkably consistent with U-Pb ages (134.1 ± 1.2 to 128.5 ± 0.9 Ma; 2 ) of magmatic zircon grains from the ore-related intrusions in each deposit, demonstrating that iron skarn mineralization was genetically related to the coeval magmatism. Our new geochronological data, when combined with existing isotopic ages, indicate that iron mineralization and associated magmatism in the Handan-Xingtai district took place mainly at the ca. 137–133 and 131–128 Ma intervals. Iron skarn deposits of similar ages also occur widely in other parts of the eastern North China craton, forming the only known giant Mesozoic iron skarn province in a cratonic block on the Earth. The formation of these iron skarn deposits and associated intrusions coincided in time with lithospheric thinning or destruction of the North China craton, strongly suggesting a causal link between the two processes.
    Print ISSN: 0361-0128
    Topics: Geosciences
    Published by Society of Economic Geologists (SEG)
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  • 13
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    SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing (2017)
    Oxford University Press
    Details
    Publication Date: 2017-01-10
    Description: Trimethylation of histone H3K36 is a chromatin mark associated with active gene expression, which has been implicated in coupling transcription with mRNA splicing and DNA damage response. SETD2 is a major H3K36 trimethyltransferase, which has been implicated as a tumor suppressor in mammals. Here, we report the regulation of SETD2 protein stability by the proteasome system, and the identification of SPOP, a key subunit of the CUL3 ubiquitin E3 ligase complex, as a SETD2-interacting protein. We demonstrate that SPOP is critically involved in SETD2 stability control and that the SPOP/CUL3 complex is responsible for SETD2 polyubiquitination both in vivo and in vitro . ChIP-Seq analysis and biochemical experiments demonstrate that modulation of SPOP expression confers differential H3K36me3 on SETD2 target genes, and induce H3K36me3-coupled alternative splicing events. Together, these findings establish a functional connection between oncogenic SPOP and tumor suppressive SETD2 in the dynamic regulation of gene expression on chromatin.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 14
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    Comparison of Elemental Composition and Solubility in the Zinc Hyperaccumulator Thlaspi caerulescens with the Non-Hyperaccumulator Thlaspi ochroleucum (2000)
    Springer
    Details
    Publication Date: 2000-09-01
    Print ISSN: 0007-4861
    Electronic ISSN: 1432-0800
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Published by Springer
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  • 15
    Electronic Resource
    Electronic Resource
    Geographical variations of trace elements in sediments of the major rivers in eastern China (2000)
    Springer
    Environmental geology 39 (2000), S. 1334-1340 
    Details
    ISSN: 1432-0495
    Keywords: Keywords China ; Geochemistry ; River ; Sediment ; Trace metals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  A total of 26 geographically and hydrologically diverse sediment samples were collected from 12 major rivers in eastern China. The 〈63-μm fraction of the sediments was analysed for both total concentrations of Cu, Zn, Pb and Cd, and their associations with various geochemical phases. The geographical variations of sediment-bound trace metals can be related to the bedrock types and weathering processes in the corresponding river basins. The rivers in southern China had notably higher concentrations of trace metals in sediments because of abundant non-ferrous mineral deposits and stronger weathering process in the region. A large proportion of trace metals in these sediments was associated with iron and manganese oxides and organic matter. Relative low levels of trace metals were found in river sediments in northern China, and a significant proportion of the metals was bound to organic matter, carbonates, and the residual fraction. The sediments in the Yellow River, originating from special loess, had the lowest concentrations of trace metals. Most of the trace metals were associated with the carbonates and residual phases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002540000224
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  • 16
    Electronic Resource
    Electronic Resource
    Comparison of Elemental Composition and Solubility in the Zinc Hyperaccumulator Thlaspi caerulescens with the Non-Hyperaccumulator Thlaspi ochroleucum (2000)
    Springer
    Bulletin of environmental contamination and toxicology 65 (2000), S. 343-350 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0012800134
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  • 17
    Electronic Resource
    Electronic Resource
    The relative amplitudes of mantle heterogeneity in P velocity, S velocity and density from free-oscillation data (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 105 (1991), S. 0 
    Details
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Splitting functions retrieved from spectra of the free oscillations are sensitive to the lateral variations in P velocity (α), S velocity (β), and density (ρ) simultaneously. In this study they are used to constrain the values of the ratios d ln α/d ln β and d ln ρ/d ln α for the lower mantle. Assuming that the upper mantle structure is obtainable from model M84A (this is not a crucial assumption as experiments indicate), the optimal value of d ln α/d ln β inferred from the modal data is 0.44 and d ln α/d ln β lies in the interval (0.39, 0.60) with 75 per cent confidence, strongly discriminating against the value (0.8) often used. The constraints on density structure of the current data are insufficient to yield new definitive results. The analysis demonstrates, however, that the value of d ln ρ/d ln α could be estimated from a larger set of modal data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-246X.1991.tb00802.x
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  • 18
    Electronic Resource
    Electronic Resource
    Determination of sulphonic compounds as their thiotrifluoroacetate derivatives by gas chromatography with ion trap detection
    Amsterdam : Elsevier
    Journal of Chromatography A 667 (1994), S. 219-223 
    Details
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0021-9673(94)89070-6
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  • 19
    Electronic Resource
    Electronic Resource
    Adaptive finite element procedures in elasticity and plasticity (1996)
    Springer
    Engineering with computers 12 (1996), S. 120-141 
    Details
    ISSN: 1435-5663
    Keywords: Discontinuous Galerkin ; Error estimation adaptivity ; Postprocessing ; Superconvergence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Notes: Abstract The paper discusses error estimation and h-adaptive finite element procedures for elasticity and plasticity problems. For the spatial discretization error, an enhanced Superconvergent Patch Recovery (SPR) technique which improves the error estimation by including fulfillment of equilibrium and boundary conditions in the smoothing procedure is discussed. It is known that an accurate error estimation on an early stage of analysis results in a more rapid and optimal adaptive process. It is shown that node patches and element patches give similar quality of the postprocessed solution. For dynamic problems, a postprocessed type of error estimate and an adaptive procedure for the semidiscrete finite element method are discussed. It is shown that the procedure is able to update the spatial mesh and the time step size so that both spatial and time discretization errors are controlled within specified tolerances. A time-discontinuous Galerkin method for solving the second-order ordinary differential equations in structural dynamics is also presented. Many advantages of the new approach such as high order accuracy, possibility to filter effects of spurious modes and convenience to apply adaptive analysis are observed. For plasticity problems, some recent work that improved plastic strains and plastic localization is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01299397
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  • 20
    Electronic Resource
    Electronic Resource
    A Mössbauer study of the bipyramidal lattice site (2b) in BaFe12O19 (1990)
    Springer
    Hyperfine interactions 62 (1990), S. 219-224 
    Details
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The hyperfine fieldsH f(T), center shifts δ(T) and relative recoilless fractionsf a(T) at different lattice sites of barium ferrite were determined by Mössbauer spectroscopy of57Fe over a temperature range from 12 to 723 K. For ferric iron in the crystalline site (2b), the recoilless fractionf a(T) decreases most with increasing temperature in comparison with that of other sites, corresponding to a characteristic temperature {ie219-1}. These results indicate that the ferric iron in the site (2b) oscillates between two equivalent positions (4e) on either side of the symmetry plane normal to thec-axis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02397701
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