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  • 11
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    Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation (2002)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: Previously, we determined that the activator protein-1 (AP-1)-binding site and the runt domain (RD)-binding site and their binding proteins, c-Fos.c-Jun and Cbfa, regulate the collagenase-3 promoter in parathyroid hormone-treated and differentiating osteoblasts. Here we show that Cbfa1 and c-Fos.c-Jun appear to cooperatively bind the RD- and AP-1-binding sites and form ternary structures in vitro. Both in vitro and in vivo co-immunoprecipitation and yeast two-hybrid studies further demonstrate interaction between Cbfa1 with c-Fos and c-Jun in the absence of phosphorylation and without binding to DNA. Additionally, only the runt domain of Cbfa1 was required for interaction with c-Jun and c-Fos. In mammalian cells, overexpression of Cbfa1 enhanced c-Jun activation of AP-1-binding site promoter activity, demonstrating functional interaction. Finally, insertion of base pairs that disrupted the helical phasing between the AP-1- and RD-binding sites also inhibited collagenase-3 promoter activation. Thus, we provide direct evidence that Cbfa1 and c-Fos.c-Jun physically interact and cooperatively bind the AP-1- and RD-binding sites in the collagenase-3 promoter. Moreover, the AP-1- and RD-binding sites appear to be organized in a specific required helical arrangement that facilitates transcription factor interaction and enables promoter activation.
    Keywords: Life Sciences (General)
    Type: The Journal of biological chemistry (ISSN 0021-9258); 277; 1; 816-22
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  • 12
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    DP Capabilities: LWA Current and Future Users Meeting (2011)
    In:  Other Sources
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    Publication Date: 2019-07-13
    Description: No abstract available
    Keywords: Astronomy
    Type: LWA Current and Future Users Meeting; May 12, 2011 - May 13, 2011; Albuquerque, NM; United States
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  • 13
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    A FPGA-based Fast Transient Search Platform for the Australian Square Kilometre Array Pathfinder (2011)
    In:  Other Sources
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    Publication Date: 2019-07-13
    Description: No abstract available
    Keywords: Astronomy
    Type: National Radio Science Meeting (USNC-URSI); Jan 05, 2011 - Jan 09, 2011; Boulder, CO; United States
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  • 14
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    Photoevaporation and the Dispersal of Disks (2014)
    In:  CASI
    Details
    Publication Date: 2019-07-20
    Description: Disk disperse in a few million years, before which they must form planets. Photoevaporation and viscosity are mainly responsible for disk dispersal. EUV, FUV and X-rays have all been suggested as photoevaporation agents, disk evolutionary scenarios and predicted mass loss rates in each case differ. Stellar mass and radiation field, disk properties, magnitude of viscosity, and dust evolution all play significant roles in determining the evolution of the disk and its lifetime. Observational diagnostics of photoevaperative flows include [Nell] and perhaps [OI]. These are at present inconclusive and better diagnostics are needed.
    Keywords: Astronomy
    Type: ARC-E-DAA-TN17213 , The Disk in Relation to The Formation of Planets And Their Protoatmospheres; Aug 25, 2014 - Aug 29, 2014; Beijing; China
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  • 15
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    Signal Processing for a Lunar Array: Minimizing Power Consumption (2011)
    In:  Other Sources
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    Publication Date: 2019-07-13
    Description: Motivation for the study is: (1) Lunar Radio Array for low frequency, high redshift Dark Ages/Epoch of Reionization observations (z =6-50, f=30-200 MHz) (2) High precision cosmological measurements of 21 cm H I line fluctuations (3) Probe universe before first star formation and provide information about the Intergalactic Medium and evolution of large scale structures (5) Does the current cosmological model accurately describe the Universe before reionization? Lunar Radio Array is for (1) Radio interferometer based on the far side of the moon (1a) Necessary for precision measurements, (1b) Shielding from earth-based and solar RFI (12) No permanent ionosphere, (2) Minimum collecting area of approximately 1 square km and brightness sensitivity 10 mK (3)Several technologies must be developed before deployment The power needed to process signals from a large array of nonsteerable elements is not prohibitive, even for the Moon, and even in current technology. Two different concepts have been proposed: (1) Dark Ages Radio Interferometer (DALI) (2)( Lunar Array for Radio Cosmology (LARC)
    Keywords: Astronomy
    Type: National Radio Science Meeting; Jan 05, 2011; Boulder, CO; United States
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  • 16
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    Peripheral leukocyte subpopulations and catecholamine levels in astronauts as a function of mission duration (2001)
    In:  Other Sources
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    Publication Date: 2019-07-13
    Description: OBJECTIVE: The objective of this study was to determine the effects of spaceflight duration on immune cells and their relationship to catecholamine levels. METHODS: Eleven astronauts who flew aboard five different US Space Shuttle flights ranging in duration from 4 to 16 days were studied before launch and after landing. RESULTS: Consistent with prior studies, spaceflight was associated with a significant increase in the number of circulating white blood cells (p 〈.01), including neutrophils (p 〈.01), monocytes (p 〈.05), CD3+CD4+ T-helper cells (p 〈.05), and CD19+ B cells (p 〈.01). In contrast, the number of CD3-CD16+56+ natural killer cells was decreased (p 〈.01). Plasma norepinephrine levels were increased at landing (p 〈.01) and were significantly correlated with the number of white blood cells (p 〈.01), neutrophils (p 〈.01), monocytes (p 〈.01), and B cells (p 〈.01). Astronauts who were in space for approximately 1 week showed a significantly larger increase on landing in plasma norepinephrine (p =.02) and epinephrine (p =.03) levels, as well as number of circulating CD3+CD4+ T-helper cells (p 〈.05) and CD3+CD8+ T-cytotoxic cells (p 〈.05) as compared with astronauts in space for approximately 2 weeks. CONCLUSIONS: The data suggest that the stress of spaceflight and landing may lead to a sympathetic nervous system-mediated redistribution of circulating leukocytes, an effect potentially attenuated after longer missions.
    Keywords: Life Sciences (General)
    Type: Psychosomatic medicine (ISSN 0033-3174); 63; 6; 886-90
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  • 17
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    Glutamine synthetase immunoreactivity is present in oligodendroglia of various regions of the central nervous system (1990)
    In:  Other Sources
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    Publication Date: 2019-07-13
    Description: Glutamine synthetase immunoreactive oligodendrocytes were identified in the cerebral cortex, cerebellum, brain stem, and spinal cord. They were mostly confined to the gray matter, particularly close to neurons and processes. The white matter showed few immunoreactive oligodendroglia. It was suggested that some type of oligodendrocytes, specially those in perineuronal location, might fulfill a functional role more akin to astrocytes than to the normally myelinating oligodendroglia.
    Keywords: Life Sciences (General)
    Type: Glia (ISSN 0894-1491); 3; 5; 335-41
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  • 18
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    Developmental regulation of collagenase-3 mRNA in normal, differentiating osteoblasts through the activator protein-1 and the runt domain binding sites (2000)
    In:  Other Sources
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    Publication Date: 2019-07-13
    Description: Collagenase-3 mRNA is initially detectable when osteoblasts cease proliferation, increasing during differentiation and mineralization. We showed that this developmental expression is due to an increase in collagenase-3 gene transcription. Mutation of either the activator protein-1 or the runt domain binding site decreased collagenase-3 promoter activity, demonstrating that these sites are responsible for collagenase-3 gene transcription. The activator protein-1 and runt domain binding sites bind members of the activator protein-1 and core-binding factor family of transcription factors, respectively. We identified core-binding factor a1 binding to the runt domain binding site and JunD in addition to a Fos-related antigen binding to the activator protein-1 site. Overexpression of both c-Fos and c-Jun in osteoblasts or core-binding factor a1 increased collagenase-3 promoter activity. Furthermore, overexpression of c-Fos, c-Jun, and core-binding factor a1 synergistically increased collagenase-3 promoter activity. Mutation of either the activator protein-1 or the runt domain binding site resulted in the inability of c-Fos and c-Jun or core-binding factor a1 to increase collagenase-3 promoter activity, suggesting that there is cooperative interaction between the sites and the proteins. Overexpression of Fra-2 and JunD repressed core-binding factor a1-induced collagenase-3 promoter activity. Our results suggest that members of the activator protein-1 and core-binding factor families, binding to the activator protein-1 and runt domain binding sites are responsible for the developmental regulation of collagenase-3 gene expression in osteoblasts.
    Keywords: Life Sciences (General)
    Type: The Journal of biological chemistry (ISSN 0021-9258); 275; 30; 23310-8
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  • 19
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    Effects of Dust Growth and Settling in T Tauri Disks (2006)
    In:  Other Sources
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    Publication Date: 2019-07-13
    Description: We presented self-consistent disk models of T Tauri stars that include a parameterized treatment of dust settling and grain growth, building on techniques developed in a series of papers by D'Alessio et al. The models incorporate depleted distributions of dust in upper disk layers along with larger sized particles near the disk midplane, which are expected theoretically and, as we suggested earlier, are necessary to account for millimeter-wave emission, SEDs, scattered light images, and silicate emission features simultaneously. By comparing the models with recent mid- and near-IR observations, we find that the dust-to-gas mass ratio of small grains at the upper layers should be less than 10% of the standard value. The grains that have disappeared from the upper layers increase the dust-to-gas mass ratio of the disk interior; if those grains grow to maximum sizes of the order of millimeters during the settling process, then both the millimeter-wave fluxes and spectral slopes can be consistently explained. Depletion and growth of grains can also enhance the ionization of upper layers, increasing the possibility of the magnetorotational instability for driving disk accretion.
    Keywords: Astronomy
    Type: The Astrophysical Journal; 638; 1; 314-335
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  • 20
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    The Most Powerful Flaring Activity from the NLSy1 PMN J0948+0022 (2014)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: We report on multifrequency observations performed during 2012 December-2013 August of the first narrow-line Seyfert 1 galaxy detected in gamma rays, PMN J0948+0022 (z equal to 0.5846). A gamma-ray flare was observed by the Large Area Telescope on board Fermi during 2012 December-2013 January, reaching a daily peak flux in the 0.1-100 GeV energy range of (155 plus or minus 31)10(exp 8) ph cm (exp 2) s (exp 1) on 2013 January 1, corresponding to an apparent isotropic luminosity of approximately 1.510)exp 48) erg s(exp 1). The gamma-ray flaring period triggered Swift and VERITAS observations in addition to radio and optical monitoring by OVRO, MOJAVE, and CRTS. A strong flare was observed in optical, UV, and X- rays on 2012 December 30, quasi-simultaneously to the gamma-ray flare, reaching a record flux for this source from optical to gamma rays. VERITAS observations at very high energy (E greater than 100 GeV) during 2013 January 6-17 resulted in an upper limit of F(sub greater than 0.2 TeV) less than 4.0 10(exp 12) ph cm(exp 2) s(exp 1). We compared the spectral energy distribution (SED) of the flaring state in 2013 January with that of an intermediate state observed in 2011. The two SEDs, modelled as synchrotron emission and an external Compton scattering of seed photons from a dust torus, can be modelled by changing both the electron distribution parameters and the magnetic field.
    Keywords: Astronomy
    Type: GSFC-E-DAA-TN24339 , Monthly Notices of the Royal Astronomical Society (ISSN 0035-8711) (e-ISSN 1365-2966); 446; 3; 2456-2467
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