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  • 11
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    ENSO drove 2500-year collapse of eastern Pacific coral reefs (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-07-07
    Description: Cores of coral reef frameworks along an upwelling gradient in Panama show that reef ecosystems in the tropical eastern Pacific collapsed for 2500 years, representing as much as 40% of their history, beginning about 4000 years ago. The principal cause of this millennial-scale hiatus in reef growth was increased variability of the El Nino-Southern Oscillation (ENSO) and its coupling with the Intertropical Convergence Zone. The hiatus was a Pacific-wide phenomenon with an underlying climatology similar to probable scenarios for the next century. Global climate change is probably driving eastern Pacific reefs toward another regional collapse.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Toth, Lauren T -- Aronson, Richard B -- Vollmer, Steven V -- Hobbs, Jennifer W -- Urrego, Dunia H -- Cheng, Hai -- Enochs, Ian C -- Combosch, David J -- van Woesik, Robert -- Macintyre, Ian G -- New York, N.Y. -- Science. 2012 Jul 6;337(6090):81-4. doi: 10.1126/science.1221168.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Florida Institute of Technology, Melbourne, FL 32901, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22767927" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Anthozoa/growth & development ; Climate Change ; *Coral Reefs ; *El Nino-Southern Oscillation ; Geologic Sediments ; Pacific Ocean ; Panama ; Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 12
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    Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-12-07
    Description: The skin is a classical example of a tissue maintained by stem cells. However, the identity of the stem cells that maintain the interfollicular epidermis and the source of the signals that control their activity remain unclear. Using mouse lineage tracing and quantitative clonal analyses, we showed that the Wnt target gene Axin2 marks interfollicular epidermal stem cells. These Axin2-expressing cells constitute the majority of the basal epidermal layer, compete neutrally, and require Wnt/beta-catenin signaling to proliferate. The same cells contribute robustly to wound healing, with no requirement for a quiescent stem cell subpopulation. By means of double-labeling RNA in situ hybridization in mice, we showed that the Axin2-expressing cells themselves produce Wnt signals as well as long-range secreted Wnt inhibitors, suggesting an autocrine mechanism of stem cell self-renewal.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081860/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081860/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lim, Xinhong -- Tan, Si Hui -- Koh, Winston Lian Chye -- Chau, Rosanna Man Wah -- Yan, Kelley S -- Kuo, Calvin J -- van Amerongen, Renee -- Klein, Allon Moshe -- Nusse, Roel -- 1R01DK085720/DK/NIDDK NIH HHS/ -- 1U01DK085527/DK/NIDDK NIH HHS/ -- 5K08DK096048/DK/NIDDK NIH HHS/ -- K08 DK096048/DK/NIDDK NIH HHS/ -- P30 DK026743/DK/NIDDK NIH HHS/ -- R01 DK085720/DK/NIDDK NIH HHS/ -- U01 DK085527/DK/NIDDK NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Dec 6;342(6163):1226-30. doi: 10.1126/science.1239730.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Biology, Howard Hughes Medical Institute (HHMI), Institute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24311688" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Autocrine Communication ; Axin Protein/genetics/metabolism ; Cell Differentiation ; Cell Lineage ; Cell Proliferation ; Cells, Cultured ; Epidermis/*cytology/injuries/metabolism ; Epithelial Cells/cytology/metabolism ; Gene Expression ; Homeostasis ; Humans ; Intercellular Signaling Peptides and Proteins/metabolism ; Keratinocytes/cytology/metabolism ; Mice ; Regeneration ; Skin/injuries ; Stem Cell Niche ; Stem Cells/cytology/*physiology ; Wnt Proteins/metabolism ; *Wnt Signaling Pathway ; Wound Healing ; beta Catenin/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 13
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    Isolation of putative progenitor endothelial cells for angiogenesis (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-14
    Description: Putative endothelial cell (EC) progenitors or angioblasts were isolated from human peripheral blood by magnetic bead selection on the basis of cell surface antigen expression. In vitro, these cells differentiated into ECs. In animal models of ischemia, heterologous, homologous, and autologous EC progenitors incorporated into sites of active angiogenesis. These findings suggest that EC progenitors may be useful for augmenting collateral vessel growth to ischemic tissues (therapeutic angiogenesis) and for delivering anti- or pro-angiogenic agents, respectively, to sites of pathologic or utilitarian angiogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Asahara, T -- Murohara, T -- Sullivan, A -- Silver, M -- van der Zee, R -- Li, T -- Witzenbichler, B -- Schatteman, G -- Isner, J M -- 2824/PHS HHS/ -- 53354/PHS HHS/ -- 57516/PHS HHS/ -- New York, N.Y. -- Science. 1997 Feb 14;275(5302):964-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine (Cardiology), St. Elizabeth's Medical Center, Tufts University School of Medicine, 736 Cambridge Street, Boston, MA 02135, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9020076" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD34/analysis ; Biomarkers/analysis ; Cell Differentiation ; Cell Separation ; Cells, Cultured ; Endothelium, Vascular/chemistry/*cytology ; Flow Cytometry ; Hindlimb/blood supply ; Humans ; Ischemia/physiopathology ; Mice ; Mice, Inbred C57BL ; Mice, Nude ; Mice, Transgenic ; *Neovascularization, Physiologic ; Nitric Oxide Synthase/analysis ; Rabbits ; Receptor Protein-Tyrosine Kinases/analysis ; Receptors, Growth Factor/analysis ; Receptors, Vascular Endothelial Growth Factor ; Stem Cells/chemistry/*cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 14
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    Parasitology. Malaria vaccines: back to the future? (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-02-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Waters, A P -- Mota, M M -- van Dijk, M R -- Janse, C J -- New York, N.Y. -- Science. 2005 Jan 28;307(5709):528-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Parasitology, Leiden University Medical Centre, Leiden 2300 RC, Netherlands. a.p.waters @lumc.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15681372" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Genes, Protozoan ; Genetic Engineering ; Hepatocytes/parasitology/physiology ; Humans ; Immunization Schedule ; Immunization, Secondary ; Malaria/*immunology/prevention & control ; *Malaria Vaccines/immunology ; Malaria, Falciparum/immunology/prevention & control ; Mice ; Plasmodium berghei/genetics/growth & development/*immunology ; Plasmodium falciparum/genetics/immunology ; Protozoan Proteins/genetics/physiology ; Sporozoites/genetics/growth & development/*immunology ; Vaccination ; Vaccines, Attenuated/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    Comment on "Coral reef death during the 1997 Indian Ocean dipole linked to Indonesian wildfires" (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-02-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van Woesik, R -- New York, N.Y. -- Science. 2004 Feb 27;303(5662):1297; author reply 1297.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Florida Institute ofTechnology, 150 West University Boulevard, Melbourne, FL 32901-6988, USA. rvw@fit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14988537" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anthozoa/*growth & development ; *Ecosystem ; *Eutrophication ; Fires ; Indian Ocean ; Indonesia ; Iron ; Phytoplankton/growth & development ; Seawater ; Temperature
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 16
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    Biodiversity effects on soil processes explained by interspecific functional dissimilarity (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-11-06
    Description: The loss of biodiversity can have significant impacts on ecosystem functioning, but the mechanisms involved lack empirical confirmation. Using soil microcosms, we show experimentally that functional dissimilarity among detritivorous species, not species number, drives community compositional effects on leaf litter mass loss and soil respiration, two key soil ecosystem processes. These experiments confirm theoretical predictions that biodiversity effects on ecosystem functioning can be predicted by the degree of functional differences among species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heemsbergen, D A -- Berg, M P -- Loreau, M -- van Hal, J R -- Faber, J H -- Verhoef, H A -- New York, N.Y. -- Science. 2004 Nov 5;306(5698):1019-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vrije Universiteit, Institute of Ecological Science, Department of Animal Ecology, de Boelelaan 1085, 1081 HV Amsterdam, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15528441" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; *Ecosystem ; Plant Leaves ; *Soil ; Soil Microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 17
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    Science publishing: The trouble with retractions (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-10-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Noorden, Richard -- England -- Nature. 2011 Oct 5;478(7367):26-8. doi: 10.1038/478026a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21979026" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Editorial Policies ; Guidelines as Topic ; Humans ; Periodicals as Topic/*standards ; Research Design/statistics & numerical data ; *Retraction of Publication as Topic ; *Science/ethics/standards ; Scientific Misconduct/statistics & numerical data
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 18
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    New year, new science (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-01-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Noorden, Richard -- Ledford, Heidi -- Mann, Adam -- England -- Nature. 2011 Jan 6;469(7328):12. doi: 10.1038/469012a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21209635" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Climate ; Drug Evaluation, Preclinical/trends ; Genome-Wide Association Study ; Genomics/economics/trends ; Hepatitis C/drug therapy ; History, Ancient ; Humans ; Induced Pluripotent Stem Cells ; Lasers ; Oceanography/trends ; Oligopeptides/therapeutic use ; Physics/trends ; Planets ; Science/*trends ; Space Flight/trends ; Spacecraft ; Synthetic Biology/trends
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 19
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    New year, new science (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-01-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Noorden, Richard -- England -- Nature. 2013 Jan 3;493(7430):11. doi: 10.1038/493011a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23282342" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astronomical Phenomena ; Clinical Trials as Topic ; Embryonic Stem Cells/transplantation ; Genes ; Global Warming ; Humans ; Intestines/microbiology ; Mental Disorders/diagnosis ; Neoplasms/drug therapy/microbiology ; Patents as Topic/legislation & jurisprudence ; Pyridones/therapeutic use ; Pyrimidinones/therapeutic use ; Reference Books ; Research Report/trends ; Research Support as Topic/economics ; Retina/cytology ; Science/*trends
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 20
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    365 days: 2013 in review (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Noorden, Richard -- Tollefson, Jeff -- Hayden, Erika Check -- Morello, Lauren -- Shen, Helen -- Butler, Declan -- Ledford, Heidi -- Witze, Alexandra -- Reich, Eugenie Samuel -- Schiermeier, Quirin -- Cyranoski, David -- England -- Nature. 2013 Dec 19;504(7480):344-9. doi: 10.1038/504344a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24352274" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astronomy/economics ; Atmosphere/chemistry ; Coronavirus Infections/epidemiology ; Disease Eradication ; Federal Government ; Fossils ; Genes ; HIV Infections/drug therapy ; History, 21st Century ; Hominidae/classification/genetics ; Humans ; Influenza A Virus, H7N9 Subtype/pathogenicity ; Neurosciences/economics/trends ; Patents as Topic/legislation & jurisprudence ; Poliomyelitis/epidemiology ; *Science/economics/history ; Stem Cell Research ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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