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  • Springer  (626)
  • American Meteorological Society (AMS)
  • 11
    ISSN: 1432-1041
    Keywords: azathioprine ; 6-thiouric acid ; 6-mercaptopurine ; renal transplantation ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The immunosuppressive activity of azathioprine (AZA) is unpredictable and depends on the formation of intracellular thiopurine ribonucleotides. However, the quantification of these active thiopurines presents difficult analytical problems. It has recently been postulated that plasma concentrations of 6-thiouric acid (6-TU) and 6-mercaptopurine (6-MP), metabolites of AZA, may provide more readily measurable indices of the pharmacologic activity of AZA. In order to evaluate the utility of 6-TU and 6-MP plasma concentrations in monitoring AZA therapy, we studied their pharmacokinetics in 6 renal transplant patients, and their in vitro immunosuppressive potency in a mixed lymphocyte proliferation assay. A peak plasma 6-TU concentration of 710.7 ng/ml was observed at 3.8 h after oral dosing. Good correlation was observed between the elimination t1/2 of 6-TU and serum creatinine, and between AUC over 24 h and serum creatinine. However, we did not observe a second peak in plasma 6-TU concentration that could be attributed to the degradation of active AZA metabolites. 6-MP plasma concentrations in the patients were low (mean peak concentration 36.0 ng/ml) and rapidly disappeared within 8 h. In vitro immunosuppressive activity could not be demonstrated for 6-TU over a concentration range of 1.25 ng/ml to 0.25 mg/ml. We conclude that 6-TU is pharmacologically inert and is primarily eliminated by the kidneys. Our findings currently do not support the use of plasma concentrations of 6-TU or 6-MP to monitor AZA therapy. In order to optimize AZA therapy, analytical techniques that are technically feasible and that can directly quantify the active intracellular thiopurines are being explored.
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  • 12
    Electronic Resource
    Electronic Resource
    Springer
    Artificial intelligence review 9 (1995), S. 129-146 
    ISSN: 1573-7462
    Keywords: natural language ; multimedia ; human-computer interaction ; communication modalities ; dialogue ; generation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract In the late Eighties the Natural Language Processing community began appreciating the role of multimodality in interactive systems. Intelligent multimodal systems are systems that integrate natural language (generally so far keyboard-based input, shortly also voice) with other media such as gestures in input or graphics in output. The perspective of what can be called visible interactive communication is discussed and considered as a possible new modality of natural language, after the spoken and the written ones. This should not be confused with the type of hypermedia that are now being developed. There, basically, the interface space is finite, even if one dimension may be added. Here the infinite creativity of human language is potentially preserved as the fundamental communication instrument.
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    Colloid & polymer science 256 (1978), S. 161-166 
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Summary The system Na4(VO3)4-NaCl-H20 is taken as an example for ultracentrifugal measurements at sedimentation equilibrium to determine the molar mass and the valency of a polymer electrolyte in a ternary system when interactions exist between the polymer and the supporting electrolyte. The experimental apparent molar mass is obtained by extrapolation to zero value of concentration of both the polymeric and supporting electrolyte. It is possible to correlate the quantity (alnyPX z /amBX)mPXz at the point m PX z = 0 mole kg-1 with the apparent valency zapp of the polymeric anion.z app is related to the stoichiometric valency by the equationz app = z =a.Z. Thus the dissociation constant can be calculated for complete dissociation of the polymer electrolyte. The dependence of zapp and (aln y PX z /a m BX ) m PX z = 0 on concentration of the supporting electrolyte called for in the correlation is verified experimentally.
    Notes: Zusammenfassung Am Beispiel des Systems Na4(VO3)4-NaCl-H2O wird untersucht, in welcher Weise Ultrazentrifugenmessungen im Sedimentationsgleichgewicht durchgeführt werden müssen, um die molare Masse und die Ladungszahl von Polymerelektrolyten in ternären Systemen unter der Bedingung von nicht vernachlässigbaren Wechselwirkungen zwischen Polymerund Fremdelektrolyt zu bestimmen. Es erweist sich, daß die experimentellen scheinbaren molaren Massen nicht nur auf die Polymerkonzentration Null extrapoliert werden müssen, sondern auch auf die Fremdelektrolytkonzentration Null. Es gelingt, die Ableitung (alnyPXz/amBx)mPXz an der StellemPXz = 0 mol kg-1 mit einer scheinbaren mittleren Ladungszahlz app des Polymeranions zu korrelieren. Zwischen dieser und der stöchiometrischen Ladungszahlz des Polymeranions besteht die Beziehungz app = Z =az, so daß die Dissoziationskonstante des Polymerelektrolyten für die summarische Dissoziation berechnet werden kann. Die aus dieser Korrelation folgenden Abhängigkeiten der scheinbaren mittleren Ladungszahlen und der Ableitung (alnypx z /amBX)Mpx z = 0 von der Konzentration des Fremdelektrolyten werden experimentell bestätigt.
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  • 14
    ISSN: 1435-1536
    Keywords: Light-scattering ; flowing polymer solution ; dilute polymer solution ; orientation and deformation of macromolecules ; polystyrene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract We describe the behavior of dilute polymer solutions by means of light-scattering under shear flow. Solution properties of polystyrene in benzene over a wide range of molecular weight has been studied to determine the coefficientsa andK of the Mark-Houwink relationship and to estimate the rheological conditions with regard to light-scattering experiments of flowing polymer solutions. The investigations were carried out to measure the shear-rate dependence of macromolecules in solution, e.g., to observe an orientation and changing of the mean-square radius of gyration.
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  • 15
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Summary The chargez of the meta-tungstate ion in the ternary system Na6[H2W12O40]-NaCl-H2O is determined by ultracentrifugation experiments, evaluating the experimental data: 1. according to the limiting value ofLamm by eytrapolating the apparent molecular weight to zero-concentration, 2. according to the procedure ofJohnson, Kraus andScatchard. The discrepancy of the results ¦z¦=6 versus ¦z¦=2,85 is resolved by giving the proof that the latter value has no physical significance. For the molecular weight the first method gives the exact value, the second furnishes a very satisfying approximation.
    Notes: Zusammenfassung Die Ladungszahlz des Metawolframations in dem ternären System Na6[H2W12O40]-NaCl-H2O wird nach zwei verschiedenen Verfahren durch Untersuchung des Sedimentations—Diffusionsgieichgewichtes mit der Ultrazentrifuge bestimmt: 1. Mit Hilfe der Lammschen Grenzbeziehung durch Extrapolation der scheinbaren Molmasse auf die Konzentration Null und 2. nach der Methode vonJohnson, Kraus undScatchard. Die Ergebnisse sind ¦z¦=6 bzw. ¦z¦=2,85. Es wird gezeigt, daß dem nach dem Verfahren vonJohnson, Kraus undScatchard erhaltenen Wert ¦z¦=2,85 keine physikalische Realitat zukommt.
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    International journal of earth sciences 59 (1969), S. 228-256 
    ISSN: 1437-3262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract An area of about 200 sq.m., consisting of epimetamorphic Precambrian schists and granites in the northern parts of the Tibesti mountains was studied by geologic interpretation of small scale aerial photographs. The scope of work was the evaluation of the structural trends in the basement complex, the distribution of lengths and azimuts of the fracture pattern, and a quantitative asessment of the drainage system. Plotting of the photogeologic and drainage map was done by a third order instrument, the ZEISS Stereotop. The network of pass points used in stereoplotting was established by slotted templet radial triangulation at a scale of 1∶50000. Fracture trace analysis showed that the fracture pattern is not related to the fold structures of the bedrock, but to a younger wrench fault system with a master shear direction of 30°. The drainage network is mature in spite of only episodic rainfalls. 15 drainage basins of 3rd to 5th order magnitude were examined closely, and channel orders, numbers and lengths as well as basin areas were determined.Horton's law of stream numbers is observed closely by all basins in spite of obvious structural control. The weighted mean bifurcation ratio is fairly constant around the value of 4.10. Mean channel lengths seem to be more sensitive to structural control, as deviations of measurements fromHorton's second law are noticeable in many basins. Drainage densities are closely grouped around a mean value of 3.53. The relation between drainage density and channel frequency found byMelton is maintained, but the values tend to be somewhat lower than described originally. Influence of fracture directions on the drainage pattern is obvious in the distribution of azimuts. ASpearman rank correlation test showed significant control of the drainage network by the directions of the fracture system. The use of aerial photographs in quantitative evaluations of fracture and drainage patterns may, in many cases, result in the procurement of more accurate data in much shorter time than by conventional methods.
    Abstract: Résumé L'interprétation photogéologique d'une région de schistes précambriens épimétamorphiques d'environ 500 km2 au versant nord du Tibesti a été effectuée en vue d'une étude quantitative des grandes structures et des réseaux de fractures et de drainage. L'analyse statistique des fractures a prouvé que les directions dominantes du réseau de fractures ne sont pas liées au plissement mais à un «wrench fault system» au sens deMoody &Hill (1956). On a pu détérminer l'ordre, le nombre et les longueurs des segments de drainage ainsi que la surface des bassins du réseau de drainage, bien développé malgré les pluies rares mais intenses. Le contrôle structural du réseau de drainage présente un écart relativement faible de la 1ère loi deHorton. Le système de drainage s'accorde toutefois moins bien à la 2e loi deHorton, manifestement plus sensitive. Sur un sous-sol uniforme au point de vue lithologique, le rapport de bifurcation est assez constant autour de la valeur moyenne Rh=4.10. La relation entre la densité du réseau de drainage et la fréquence des segments découverte parMelton (1958) s'est confirmée. La comparaison des directions des réseaux de fractures et de drainage démontre nettement l'influence, prouvée par un test de corrélationSpearman, des directions tectoniques sur le système de drainage. L'analyse photogéologique de photographies aériennes permet une étude quantitative de réseux de fractures et de drainage en moins de temps et avec une précision souvent supérieure aux mesures faites sur des cartes ou sur le terrain.
    Notes: Zusammenfassung In einem Bereich präkambrischer epizonal metamorpher Schiefer von rund 500 km2 am Nordabfall des Tibestigebirges wurde eine photogeologische Untersuchung durchgeführt, um neben den Großstrukturen das Kluftnetz und das Entwässerungsnetz möglichst quantitativ zu erfassen. Die statistische Kluftanalyse ergab, daß die vorherrschenden Richtungen des Kluftnetzes genetisch nicht mit dem Faltenbau in Verbindung gebracht werden können, sondern an ein „wrench fault system“ im Sinne vonMoody &Hill (1956) gebunden sind. An dem voll entwickelten Entwässerungsnetz von Trockentälern, die nur während der episodischen, aber intensiven Regenfälle Wasser führen, wurden die Ordnungen, Anzahlen und Längen der Talsegmente sowie die Fläche der einzelnen Entwässerungsbecken bestimmt. Die bei struktureller Kontrolle des Entwässerungsnetzes zu erwartenden Abweichungen vonHorton's 1. Gesetz sind verhältnismäßig gering. Das Talsystem folgt jedoch dem offenbar sensitiveren 2.Horton'schen Gesetz wesentlich schlechter. Bei lithologisch gleichmäßigem Untergrund liegt das mittlere Bifurkationsverhältnis recht konstant um den Wert Rb=4,10. Der vonMelton (1958) gefundene gesetzmäßige Zusammenhang zwischen Entwässerungsdichte und Talsegment-Häufigkeit konnte bestätigt werden. Ein Vergleich der Richtungsverteilungen von Kluft- und Talnetz erweist die deutliche Beeinflussung des Entwässerungssystems durch die tektonischen Richtungen; einSpearman-Rangkorrelationstest ergibt für die Mehrzahl der Bekken bei einem Signifikanzniveau von α=0,100 eine signifikante Beeinflussung des Entwässerungsnetzes durch die Kluftrichtungen. Für quantitative Untersuchungen über Kluftnetz und Entwässerungsnetz bietet die photogeologische Auswertung von Luftbildern nicht nur Vorteile im Zeit- und Arbeitsaufwand, sondern teilweise auch höhere Genauigkeit gegenüber Messungen aus Karten oder im Gelände.
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  • 17
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 212 (1968), S. 83-103 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Within the framework of the hydrodynamic model the exact coupling constants of the coupling of the giant multipole resonances to the surface quadrupole oscillations of nuclei are derived. The differences to former variational calculations are discussed. It is found that the coupling constants for the terms linear in the surface variables are almost the same whereas the coupling constants for the quadratic terms differ appreciably. The influence on the photon absorption and scattering cross sections of spherical nuclei is discussed.
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  • 18
    Electronic Resource
    Electronic Resource
    Springer
    Experiments in fluids 2 (1984), S. 89-93 
    ISSN: 1432-1114
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A laser doppler anemometer (LDA) was used to measure local dispersion coefficients of particles in turbulent flow. The experimental set-up is described along with the data acquisition equipment and processing procedures. Results for 5 μ particles dispersing from a point source in pipe flow are shown. A second estimate for the diffusivity was obtained from mean square dispersion measurements.
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  • 19
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' journal of analytical chemistry 361 (1998), S. 645-646 
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A cold working steel was coated both with high temperature CVD (TiN) and moderate temperature CVD (Ti[C,N]). AES depth profiles show a significant difference at the interface, where a thin oxide layer remains detectable at deposition temperatures of 750 °C. It could be shown that an impedance signal at a frequency of 13 MHz is well suited to detect the early stages of the growth of a CVD coating.
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  • 20
    Electronic Resource
    Electronic Resource
    Springer
    Chromatographia 39 (1994), S. 375-375 
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
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