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  • ASTROPHYSICS  (1,196)
  • Life and Medical Sciences  (850)
  • Humans  (599)
  • Lunar and Planetary Science and Exploration
  • 1985-1989  (1,895)
  • 1975-1979  (715)
  • 1955-1959  (40)
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Year
  • 11
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    Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer's disease (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-10-30
    Description: The possibility that Alzheimer's disease (AD) is caused by overexpression or duplication of one or more genes on chromosome 21 has been raised by the observation of AD-like neuropathologic changes in individuals with Down syndrome and by the mapping of both the defect for familial AD and the amyloid beta protein gene to this autosome. Possible duplication on chromosome 21 was investigated in both familial and sporadic AD by means of restriction fragment length polymorphisms for the amyloid and SODI loci, as well as for DNA markers in the vicinity of the familial AD defect and in the critical Down syndrome region of chromosome 21. No evidence of increased DNA dosage was observed in either brain or leukocytes of patients with inherited or sporadic forms of AD. Duplication of these regions is therefore not a frequent event in either form of AD. Furthermore, no significant allelic association was detected between AD and any of the loci, including the amyloid and SODI genes, providing no support for the hypothesis that defects in these specific genes are the primary cause of AD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉St George-Hyslop, P H -- Tanzi, R E -- Polinsky, R J -- Neve, R L -- Pollen, D -- Drachman, D -- Growdon, J -- Cupples, L A -- Nee, L -- Myers, R H -- ADRC P50 AGO5134-02/AD/ADAMHA HHS/ -- NS20012/NS/NINDS NIH HHS/ -- R01 AGO6865-1/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1987 Oct 30;238(4827):664-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neurogenetics Laboratory, Massachusetts General Hospital, Boston.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2890206" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Alzheimer Disease/*genetics ; Amyloid/genetics ; *Chromosomes, Human, Pair 21 ; Genes ; Genetic Linkage ; Humans ; Polymorphism, Restriction Fragment Length
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 12
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    Selective extraction of small and large molecules from the cerebrospinal fluid by Purkinje neurons (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-04-19
    Description: Cerebellar Purkinje neurons accumulated propidium iodide, granular blue, and horseradish peroxidase conjugated to wheat germ agglutinin but not unconjugated horseradish peroxidase, bisbenzimide, or Evans blue when these compounds were infused into the lateral cerebral ventricles of awake, unrestrained rats. Accumulation of propidium iodide by Purkinje neurons of the vermis was associated with a reproducible behavioral abnormality characterized by truncal tremor, ataxia, and nystagmus. Both the accumulation of propidium iodide in Purkinje cells and the behavioral abnormality were prevented by prior intracerebroventricular administration of ouabain or colchicine, drugs that block neuronal transport processes. The ability of cerebellar Purkinje neurons to extract small and large molecules from the cerebrospinal fluid has important implications for their physiology and pathology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Borges, L F -- Elliott, P J -- Gill, R -- Iversen, S D -- Iversen, L L -- New York, N.Y. -- Science. 1985 Apr 19;228(4697):346-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2580350" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bisbenzimidazole/metabolism ; Cerebrospinal Fluid/*physiology ; Dendrites/physiology ; Evans Blue/metabolism ; Horseradish Peroxidase/metabolism ; Humans ; Male ; Propidium/metabolism/pharmacology ; Purkinje Cells/*metabolism/physiology ; Rats ; Rats, Inbred Strains ; Tremor/chemically induced/physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    Expression of Plasmodium falciparum circumsporozoite proteins in Escherichia coli for potential use in a human malaria vaccine (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-24
    Description: The circumsporozoite (CS) protein of the human malaria parasite Plasmodium falciparum may be the most promising target for the development of a malaria vaccine. In this study, proteins composed of 16, 32, or 48 tandem copies of a tetrapeptide repeating sequence found in the CS protein were efficiently expressed in the bacterium Escherichia coli. When injected into mice, these recombinant products resulted in the production of high titers of antibodies that reacted with the authentic CS protein on live sporozoites and blocked sporozoite invasion of human hepatoma cells in vitro. These CS protein derivatives are therefore candidates for a human malaria vaccine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Young, J F -- Hockmeyer, W T -- Gross, M -- Ballou, W R -- Wirtz, R A -- Trosper, J H -- Beaudoin, R L -- Hollingdale, M R -- Miller, L H -- Diggs, C L -- New York, N.Y. -- Science. 1985 May 24;228(4702):958-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2988125" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibody Formation ; Antigens, Surface/genetics/*immunology ; Carcinoma, Hepatocellular ; Cell Line ; Cloning, Molecular ; Cross Reactions ; DNA, Recombinant ; Escherichia coli/genetics ; Humans ; Liver Neoplasms ; Malaria/*prevention & control ; Mice ; Plasmodium/immunology ; Plasmodium falciparum/genetics/*immunology/physiology ; *Protozoan Proteins ; Vaccines/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 14
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    Tissue distribution and developmental expression of the messenger RNA encoding angiogenin (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-07-17
    Description: New blood vessel growth occurs during normal fetal development and in diseases such as cancer and diabetes. The polypeptide angiogenin induces new blood vessel growth in two biological assays and may play a role in the vascular development of the fetus and in the neovascularization that accompanies diseases and wound healing. A complementary DNA probe for human angiogenin was used to examine the tissue distribution of angiogenin messenger RNA (mRNA) in the developing rat and in selected transformed cell lines. Angiogenin mRNA was detected predominantly in adult liver but was also detectable at low levels in other tissues. The expression of the angiogenin gene in rat liver was found to be developmentally regulated; mRNA levels were low in the developing fetus, increased in the neonate, and maximal in the adult. The amount of angiogenin mRNA in human HT-29 colon carcinoma and SK-HEP hepatoma cells was not greater than that in normal rat liver. These results demonstrate that angiogenin is predominantly expressed in adult liver, that the pattern of angiogenin gene expression is not temporally related to vascular development in the rat, and that the transformed cells studied do not contain more angiogenin mRNA than does normal liver. If angiogenin activity is controlled at the transcriptional level, the results of this study suggest that the primary function of angiogenin in vivo may be in processes other than the regulation of vascular growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiner, H L -- Weiner, L H -- Swain, J L -- HL26831/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1987 Jul 17;237(4812):280-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2440105" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Animals ; Cell Line ; Gene Expression Regulation ; Humans ; Liver/physiology ; Neoplasm Proteins/*genetics ; Neovascularization, Pathologic ; RNA, Messenger/genetics ; Rats ; *Ribonuclease, Pancreatic ; Tissue Distribution
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-08-22
    Description: A new family of protein kinase C-related genes has been identified in bovine, human, and rat genomes. The alpha-, beta-, and gamma-type protein kinase sequences are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions. The corresponding genes are located on distinct human chromosomes; the possibility of even greater genetic complexity of this gene family is suggested by Northern and Southern hybridization analyses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coussens, L -- Parker, P J -- Rhee, L -- Yang-Feng, T L -- Chen, E -- Waterfield, M D -- Francke, U -- Ullrich, A -- New York, N.Y. -- Science. 1986 Aug 22;233(4766):859-66.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3755548" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cattle ; Chromosome Mapping ; Chromosomes, Human, 16-18 ; Dna ; Genes ; Humans ; Nucleic Acid Hybridization ; Protein Kinase C/*genetics ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 16
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    Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-10-04
    Description: The T-cell tropic retrovirus of macaque monkeys STLV-III has morphologic, growth, and antigenic properties indicating that it is related to HTLV-III/LAV, the etiologic agent of the acquired immune deficiency syndrome (AIDS) in humans. Four of six rhesus monkeys died within 160 days of STLV-III inoculation with a wasting syndrome, opportunistic infections, a primary retroviral encephalitis, and immunologic abnormalities including a decrease in T4+ peripheral blood lymphocytes. These data show that an immunodeficiency syndrome can be produced experimentally in a nonhuman primate by an agent from the HTLV-III/LAV group of retroviruses. The STLV-III-macaque system will thus provide a useful model for the study of antiviral agents and vaccine development for human AIDS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Letvin, N L -- Daniel, M D -- Sehgal, P K -- Desrosiers, R C -- Hunt, R D -- Waldron, L M -- MacKey, J J -- Schmidt, D K -- Chalifoux, L V -- King, N W -- AI 20729/AI/NIAID NIH HHS/ -- CA 34979/CA/NCI NIH HHS/ -- CA 38205/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Oct 4;230(4721):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2412295" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*microbiology/pathology ; Animals ; Brain/pathology ; Deltaretrovirus ; *Disease Models, Animal ; Epitopes/analysis ; Humans ; Interleukin-2 ; Leukocyte Count ; Lymphocyte Activation ; Macaca mulatta ; Microscopy, Electron ; Pancreas/pathology ; *Retroviridae ; T-Lymphocytes/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 17
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    Occultation studies of the solar system (1986)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Determination of the size, shape, mean density, and albedo of Ceres was made. Predictions for 133 occultations of bright stars occurring in 1986 and 1987 were completed and published, as have predictions of occultations of stars by Comet Halley. Twenty-nine mutual events involving Galilean satellites were observed at Flagstaff in 1985.
    Keywords: ASTROPHYSICS
    Type: NASA, Washington Reports of Planetary Astronomy, 1985; p 108-109
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  • 18
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    The radiation history of material returned by the Soviet automatic stations Luna 16 and Luna 20, according to track studies (1977)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: Fission tracks formed by the vH (very heavy) nuclei group of solar and galactic cosmic rays have been studied in silicate minerals of the lunar regolith returned by the Luna 16 and Luna 20 unmanned spacecraft. It is shown that the material in the Luna 16 core sample, from a typical mare region of the lunar surface, has undergone stronger irradiation by cosmic rays than material returned a highland region by Luna 20. A low-irradiation component (about 10 percent of the total number of crystals) has been found in the Luna 20 core sample materials, which can possibly be attributed to material added to the main bulk of the regolith in the formation of the crater Apollonius C. From the track density distribution of crystals, as a function of depth in the regolith core sample, it follows that the process of formation of the upper layer of the regolith, both for the lunar mare and for the highland region, includes sequential layering of finely crushed crystalline matter and subsequent mixing of it by micrometeorite bombardment. A portion of the crystals with a very high track density may be a component added to the lunar surface from outer space.
    Keywords: ASTROPHYSICS
    Type: NASA, Washington The Soviet-Am. Conf. on Cosmochem. of the Moon and Planets, Pt. 2; p 745-754
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  • 19
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    The molecular gas in the supernova remnant IC443 (1986)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: Although a few highly perturbed regions characterized by gas motions with velocities larger than 20 km/s have been discovered during the last several years in the supernova remnant (SNR) IC 443, the nature of these perturbed clumps and their relationship to the quiescent molecular gas near the SNR remains unknown. In part, this is due to a lack of large-scale, high angular resolution observations. Therefore, a systematic survey of this SNR in the CO (J=1 yields 0) line has been conducted, covering a roughly 50' x 50' region spaced by 2'. The observations were made with the 14 m telescope of the Five College Radio Astronomy Observatory (FCRAO), which has a resolution of 45" and a single sideband receiver temperature of 200 K at 2.6 mm wavelength. Five new clumps were discovered, bringing the total number of known perturbed regions to eight. To study the physical structure of these clumps in more detail, more complete maps of the clumps have been made in both the CO(J=1 yields 0) and (J=2 yields 1) transitions with the FCRAO telescope. These maps show that the extent of perturbed gas in a typical clump is several arcmin, or a few pc at a distance of 1.5 kpc.
    Keywords: ASTROPHYSICS
    Type: NASA. Ames Research Center Summer School on Interstellar Processes: Abstracts of Contributed Papers; p 69-70
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  • 20
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    Investigation of the composition of the Luna 16 lunar sample (1977)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: The concentrations of aluminum, manganese, sodium, chromium, iron, cobalt, and 12 rare earth elements were determined by neutron activation analysis using slow neutrons. Oxygen and silicon were determined using a fast neutron generator. Mossbauer spectroscopy was used to investigate iron compounds in Luna 16 regolith samples from the upper part of the core.
    Keywords: ASTROPHYSICS
    Type: NASA, Washington The Soviet-Am. Conf. on Cosmochem. of the Moon and Planets, pt. 1; p 277-280
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