Publication Date:
1980-12-12
Description:
Vasoactive intestinal peptide, a smooth-muscle relaxant neuropeptide with neurotransmitter properties, was relaxed during electrical field stimulation of guinea pig trachea. The amount released correlated with the degree of relaxation, and the release was blocked by tetrodotoxin. Prior incubation of the trachea with antiserum to vasoactive intestinal peptide reduced the relaxation. Thus vasoactive intestinal peptide may mediate the nonadrenergic relaxation of tracheal smooth muscle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matsuzaki, Y -- Hamasaki, Y -- Said, S I -- HL-14187/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1980 Dec 12;210(4475):1252-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6254154" target="_blank"〉PubMed〈/a〉
Keywords:
Adrenergic Fibers/*physiology
;
Animals
;
Antigen-Antibody Reactions
;
Electric Stimulation
;
Female
;
Gastrointestinal Hormones/*physiology
;
Humans
;
Mice
;
*Muscle Contraction
;
*Muscle Relaxation
;
Muscle, Smooth/drug effects
;
Neural Inhibition
;
Synaptic Transmission
;
Tetrodotoxin/pharmacology
;
Trachea/*innervation
;
Vasoactive Intestinal Peptide/immunology/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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