ISSN:
1573-5028
Schlagwort(e):
ribosome-inactivating proteins
;
translation inhibition
;
RNA N-glycosidase
;
Sambucus nigra
;
protein synthesis
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
Notizen:
Abstract The bark ofSambucus nigra L. contains a non-toxic novel type 2 ribosome-inactivating protein that we named nigrin b.In vitro, nigrin b strongly inhibited mammalian protein synthesis but did not affect plant nor bacterial protein synthesis. The protein (M r 58 000) contains two subunits, A (M r 26 000) and B (M r 32 000); linked by disulphide bridge(s). Nigrin b was found to be an rRNA N-glycosidase of the rRNA of intact mammalian ribosomes and shares a very good N-terminal amino-acid sequence homology with the anti-HIV-1 proteins TAP 29 and trichosanthin.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00028990
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