ISSN:
1435-232X
Schlagwort(e):
Key words Chromosome 9p21-22
;
Polymorphic markers
;
Histone H3.3B Pseudogene
;
Loss of heterozygosity
;
Retroposon
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
,
Medizin
Notizen:
Abstract Alterations in chromosomal region 9p21-22 are among the most frequently encountered cytogenetic changes present in a number of human malignancies. In addition, the causative genes of a number of hereditary cancers have been genetically mapped to this region. We describe the isolation and precise localization of four novel polymorphic markers and a previously identified marker, D9S1846, from this region. Moreover, we have identified a retroposon-rich area within this oncogenic region containing a processed H3.3B pseudogene flanked by an L1 sequence and an Alu element. Together, these finely mapped and ordered reagents should prove useful for genetic mapping, sequencing, and loss of heterozygosity studies of the 9p21-22 region.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/s100380050174
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