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  • Chemistry  (6)
  • Tyrosinase  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Tyrosinase epitope recognized by an HLA-DR-restricted T-cell line from a Vogt-Koyanagi-Harada disease patient (1998)
    Springer
    Immunogenetics 47 (1998), S. 398-403 
    Details
    ISSN: 1432-1211
    Schlagwort(e): Key words HLA ; Peptide ; VKH disease ; Tyrosinase ; T-cell response
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract  Human T-cell-mediated autoimmune diseases are often genetically linked to particular alleles of HLA class II genes. Vogt-Koyanagi-Harada’s (VKH) disease, which is regarded as an autoimmune disorder in multiple organs containing melanocytes, has been found to be associated with HLA-DR4 (DRB1*0405) and HLA-DR53 (DRB4*0101). Tyrosinase is a melanoma antigen (Ag) expressed by normal melanocytes as well as melanoma cells against which responses by autologous T cells have been detected. We established a T-cell line from the peripheral blood of a patient with VKH disease which responded to synthetic peptides corresponding to tyrosinase. The T-cell line was generated which recognized the tyrosinase p188 – 208 peptide when presented by the HLA-DR4 (DRB1*0405) molecule on the surface of HLA class II-expressing L-cell transfectants. The minimal antigenic peptide which induced T-cell responses was an 11-amino-acid sequence and located at tyrosinase p193 – 203 (E-I-W-R-D-I-D-F-A-H-E). This peptide contained the DRB1*0405-binding peptide motif (hydrophobic residues (Y, F, W) at position 1 as an anchor residue, and negatively charged residues (D, E) at position 9), which corresponded to the W at p195 and the D at p203. These observations demonstrate that tyrosinase peptides are immunogenic, and may be a candidate for an autoantigen in VKH disease, suggesting that probing the T-cell responses against synthetic peptides is a productive approach for identifying the autoantigenic peptides associated with autoimmune diseases including VKH disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002510050375
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Evidence and mechanisms of filling polymerization by plasma-induced graft polymerization (1996)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 34 (1996), S. 1203-1208 
    Details
    ISSN: 0887-624X
    Schlagwort(e): plasma polymerization ; graft polymerization ; polyethylene ; poly(methylacrylate) ; membrane ; Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Using a plasma-induced graft polymerization technique, which is well known as a surface modification method, the grafted polymer was formed in pores of the porous material. This study examined the filling mechanism. Five thin porous films were sandwiched together, and employed as the substrate. The substrate was treated by plasma, and the change in surface tension and radical formation was measured for each sheet after the sheet was separated. The only surface on which surface-tension change was detected, was that of the sheet directly exposed to the plasma. Although plasma treatment made polymer radicals primarily on the outer surface of the sheet, the treatment also formed a few radicals inside the sheets. The radicals inside the sheets reacted with methylacrylate and grafted polymer formed in the pores. The location of grafted polymer depended on the balance between monomer diffusivity and reactivity. The grafting rate depended on which monomer solvent was used for the polymerization. Thus, the grafted membrane morphology could be controlled by varying the grating solvent composition. © 1996 John Wiley & Sons, Inc.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Ethanol-selective membrane for reverse osmosis of ethanol/water mixture (1990)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 36 (1990), S. 1118-1120 
    Details
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aic.690360719
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Effects of osmotic pressure and adsorption on ultrafiltration of ovalbumin (1990)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 36 (1990), S. 907-915 
    Details
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The influence of osmotic pressure and solute adsorption on permeate flux during ultrafiltration of a solute that forms a gel-like layer on membrane surfaces was investigated. Ovalbumin solutions were ultrafiltrated using three different kinds of membranes, polyolefine, polysullfone, and polyacrylonitrile. Flux data were analyzed by three conventional models: gel polarization, osmotic pressure, and resistance in series.The experimental data were in conflict with all conventional models. Data analysis suggested that the main factors which influence permeate flux decline were osmotic pressure increase at the membrane surface and resistance caused by solute adsorption.A new model, which takes into account both osmotic pressure and resistance due to solute adsorption, is proposed. Permeate flux declines observed in the experiments fit this model quite precisely. The gel layer that forms on the membrane surface has little influence on permeate flux and can be neglected.
    Zusätzliches Material: 11 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aic.690360612
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Chlorinated organics removal from water by plasma-graft filling polymerized membranes (1996)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 42 (1996), S. 892-895 
    Details
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aic.690420328
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Analysis of data in reverse osmosis with porous cellulose acetate membranes used (1967)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 13 (1967), S. 497-503 
    Details
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Reverse osmosis experimental data for some inorganic salts with the porous cellulose acetate membrane used were analyzed to obtain their diffusivity in the membrane. A parameter including the diffusivity was found constant for each film in the concentration range investigated for a particular solute at a particular pressure. This parameter was also independent of feed flow rate. The effect of operating pressure on the parameter was found to depend on the film shrinkage. Mass transfer coefficient between the membrane and the feed solution was also obtained by the analysis, and this value was independently checked by the diffusion current method. Coincidence of these coefficients shows that the ordinary mass transfer coefficient can be used in reverse osmosis with the appropriate driving force. These facts facilitate the prediction of solute separation and membrane throughput rate in reverse osmosis.
    Zusätzliches Material: 8 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aic.690130319
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Characteristics of macromolecular gel layer formed on ultrafiltration tubular membrane (1979)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 25 (1979), S. 615-622 
    Details
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Characteristics of the gel layer were investigated by direct measurement of its concentration treating polyvinylalcohol and ovalbumin aqueous solutions, using cellulose acetate tubular ultrafiltration membranes. The concentration of the gel layer was not constant but a function of bulk concentration and feed velocity. The mass transfer coefficient obtained agreed with Deissler correlation. There was a definite correlation between the resistance of the gel layer and its concentration.
    Zusätzliches Material: 13 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aic.690250407
    Standort Signatur Erwartet Verfügbarkeit
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