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  • 1
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    Effect of prolonged space flight on cardiac function and dimensions (1977)
    In:  CASI
    Details
    Publikationsdatum: 2006-01-16
    Beschreibung: By taking advantage of the capabilities of echocardiography to measure noninvasively left ventricular volume, stroke volume, and ejection fraction, and of the fact that the astronauts were routinely subjected to lower body negative pressure (whereby cardiac filling is progressively decreased), it was possible to construct classic ventricular function curves noninvasively, thereby obviating the difficulties encountered in comparing cardiac function at different end-diastolic volumes preflight and postflight. In this manner, the effect of an 84-day period of weightlessness on cardiac structure and function was evaluated in the Skylab 4 astronauts.
    Schlagwort(e): AEROSPACE MEDICINE
    Materialart: NASA., JSC Biomed. Results from Skylab; p 366-371
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 2
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    Studies of acid-base homeostasis during simulated weightlessness: Application of the water immersion model to man (1975)
    In:  Other Sources
    Details
    Publikationsdatum: 2011-08-16
    Beschreibung: The effects of water immersion on acid-base homeostasis were investigated under carefully controlled conditions. Studies of renal acidification were carried out on seven healthy male subjects, each consuming a diet containing 150 meq sodium and 100 meq potassium. Control and immersion studies were carried out on each subject on the fourth and sixth days, respectively, of dietary equilibration, by which time all subjects had achieved sodium balance. The experimental protocols on study days were similar (except for the amount of water administered).
    Schlagwort(e): AEROSPACE MEDICINE
    Materialart: NASA. Johnson Space Center Proc. of the 1973 JSC Endocrine Program Conf.; 11 p
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 3
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    Effects of water immersion to the neck on pulmonary circulation and tissue volume in man (1976)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-06-27
    Beschreibung: A rapid noninvasive breathing method is used to obtain serial measurements of the pulmonary capillary blood flow, diffusing capacity per unit of alveolar volume, combined pulmonary tissue plus capillary volume, functional residual capacity, and oxygen consumption in five normal subjects undergoing 6 h of sitting, 4 h of sitting while immersed to the neck in thermoneutral water, and 4 h of lying in thermoneutral water to the neck. The rebreathing method employed a test gas mixture containing 0.5% C2H2, 0.3% C(18)O, 10% He, 21% O2, and balance N2. It is shown that immersion to the neck in the seated posture results in significant increases in sodium excretion cardiac output, and diffusing capacity per unit of alveolar volume. The pulmonary tissue plus capillary volume did not change, demonstrating that the central vascular engorgement induced by water immersion is not accompanied by significant extravasation of fluid into the pulmonary interstitial space.
    Schlagwort(e): AEROSPACE MEDICINE
    Materialart: Journal of Applied Physiology; 40; Mar. 197
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Comparison of water immersion and saline infusion as a means of inducing volume expansion in man (1975)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-06-27
    Beschreibung: The study compares the natriuresis induced by head-out water immersion to that of a standard saline infusion and assesses the relative effectiveness of these two techniques as volume determinants of renal sodium and water handling in humans in a seated posture. The data obtained show that the volume stimulus of immersion is identical to that of standard saline-induced extracellular fluid volume expansion (ECVE) in normal seated subjects. The ability of head-out water immersion to induce a natriuresis without a concomitant increase in total blood volume and with a decrease in body weight suggests that water immersion may be preferred as an investigative tool for assessing the effects of ECVE in man.
    Schlagwort(e): AEROSPACE MEDICINE
    Materialart: Journal of Applied Physiology; 39; July 197
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    Suppression of ADH during water immersion in normal man (1975)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-06-27
    Beschreibung: A study was undertaken to ascertain whether diuresis induced by immersion is medicated by an inhibition of ADH. Immersion resulted in a progressive decrease in ADH excretion from 80.1 + or - 7 (SEM) to 37.3 + or - 6.3 microU/min (P less than 0.025). Cessation of immersion was associated with a marked increase in ADH from 37.3 + or - 6.3 microU/min to 176.6 + or - 72.6 microU/min during the recovery hour (P less than 0.05). Concomitant with these changes, urine osmolality decreased significantly beginning as early as the initial hour of immersion from 1044 + or - 36 to 542 + or - 66 mosmol/kg H2O during the final hour of immersion (P less than 0.001). These findings are consistent with the earlier suggestion that suppression of ADH release contributes to enhanced free water clearance in hydrated subjects undergoing immersion.
    Schlagwort(e): AEROSPACE MEDICINE
    Materialart: Journal of Applied Physiology; 38; June 197
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
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    Suppression of plasma renin and plasma aldosterone during water immersion in normal man (1975)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-06-27
    Schlagwort(e): AEROSPACE MEDICINE
    Materialart: Journal of Clinical Endocrinology and Metabolism; 41; Sept
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 7
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    Effects of water immersion on renal hemodynamics in normal man (1976)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-06-27
    Beschreibung: The present study was undertaken to delineate the effects of water immersion to the neck (NI) on renal plasma flow and glomerular filtration rate as assessed by the clearance of p-aminohippuric acid (PAH) and inulin, respectively. Nine normal male subjects were studied on two occasions, control and NI. The conditions of seated posture and time of day were identical. Immersion did not alter either clearance at a time when sodium excretion was increasing markedly. The constancy of PAH clearance during NI suggests that renal blood flow is unaltered and that the natriuresis of NI is mediated independently of alterations in overall renal perfusion. The sluggish decline of a natriuresis during recovery is consistent with the presence of a humoral factor contributing to the encountered natriuresis.
    Schlagwort(e): AEROSPACE MEDICINE
    Materialart: Journal of Applied Physiology; 41; Aug. 197
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 8
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    Cardiovascular and renal effects of head-out water immersion in man - Application of the model in the assessment of volume homeostasis (1976)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-06-27
    Schlagwort(e): AEROSPACE MEDICINE
    Materialart: Circulation Research; 39; Nov. 197
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 9
    Digitale Medien
    Digitale Medien
    Surface ablation in the impingement region of a liquid jet (1979)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 25 (1979), S. 630-638 
    Details
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: A theoretical and experimental investigation of a water jet impinging on a melting solid surface has been carried out. Ice, octane, p-xylene, and olive oil served as the meltable solid materials, comprising a Prandtl number range of 5 to 2 800. An available laminar stagnation flow model was utilized to describe melting heat transfer in the jet impingement region. Melting rate measurements were found to agree quite well with the values predicted with this model.
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aic.690250409
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Kinetics of nucleic acid-large ligand interactions: Exact Monte Carlo treatment and limitingl cases of reversible binding (1979)
    New York : Wiley-Blackwell
    Biopolymers 18 (1979), S. 2037-2050 
    Details
    ISSN: 0006-3525
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Many ligands, including basic polypeptides, histones, and other proteins bind nonspecifically to DNA in such a way as to render unavailable for further binding several contiguous sites (generally bases or base pairs). An accurate description of the kinetics of such large ligand binding requires a more complex theoretical analysis than does the study of the binding of small ligands to DNA. An exact analytical solution of the problem does not appear feasible. Instead, a Monte Carlo approach is developed which provides an essentially exact numerical solution by simulating the binding experiment using a model one-dimensional lattice to represent the DNA molecule. For the limiting cases of totally irreversible binding and of instantaneous redistribution of bound ligands along the lattice, relatively simple equations can be written and solved for the binding kinetics. These solutions and their realms of applicability are discussed in some detail.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bip.1979.360180815
    Standort Signatur Erwartet Verfügbarkeit
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