Publikationsdatum:
2014-11-19
Beschreibung:
Article Topoisomerase IIß-binding protein 1 (TopBP1) is known to suppress apoptosis in cancer and to mediate effects of p53 mutations. Here the authors identify calcein as a lead compound to inhibit TopBP1 and show that calcein has anti-tumour activity in mouse cancer models. Nature Communications doi: 10.1038/ncomms6476 Authors: Pinki Chowdhury, Gregory E. Lin, Kang Liu, Yongcheng Song, Fang-Tsyr Lin, Weei-Chin Lin
Digitale ISSN:
2041-1723
Thema:
Biologie
,
Chemie und Pharmazie
,
Allgemeine Naturwissenschaft
,
Physik
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