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  • 1
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    Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-01-10
    Beschreibung: The interleukin-1beta (IL-1beta) converting enzyme (ICE) processes the inactive IL-1beta precursor to the proinflammatory cytokine. ICE was also shown to cleave the precursor of interferon-gamma inducing factor (IGIF) at the authentic processing site with high efficiency, thereby activating IGIF and facilitating its export. Lipopolysaccharide-activated ICE-deficient (ICE-/-) Kupffer cells synthesized the IGIF precursor but failed to process it into the active form. Interferon-gamma and IGIF were diminished in the sera of ICE-/- mice exposed to Propionibacterium acnes and lipopolysaccharide. The lack of multiple proinflammatory cytokines in ICE-/- mice may account for their protection from septic shock.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gu, Y -- Kuida, K -- Tsutsui, H -- Ku, G -- Hsiao, K -- Fleming, M A -- Hayashi, N -- Higashino, K -- Okamura, H -- Nakanishi, K -- Kurimoto, M -- Tanimoto, T -- Flavell, R A -- Sato, V -- Harding, M W -- Livingston, D J -- Su, M S -- New York, N.Y. -- Science. 1997 Jan 10;275(5297):206-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vertex Pharmaceuticals, Inc., 130 Waverly Street, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8999548" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; COS Cells ; Caspase 1 ; Caspase 3 ; *Caspases ; Caspases, Initiator ; Culture Media, Conditioned ; Cysteine Endopeptidases/*metabolism ; Cytokines/blood/*metabolism/pharmacology ; Humans ; Interferon-gamma/biosynthesis/blood ; Interleukin-18 ; Kupffer Cells/*metabolism ; Lipopolysaccharides/pharmacology ; Mice ; Protein Precursors/metabolism ; Protein Processing, Post-Translational ; Recombinant Proteins/metabolism/pharmacology ; Spleen/cytology/metabolism ; Transfection
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
    Digitale Medien
    Digitale Medien
    Preparation of Self-Assembled Monolayers on InP (1995)
    s.l. : American Chemical Society
    Langmuir 11 (1995), S. 1849-1851 
    Details
    ISSN: 1520-5827
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/la00006a003
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  • 3
    Digitale Medien
    Digitale Medien
    Use of Single Isomorphous Replacement Data of Proteins – Resolving the Phase Ambiguity and a New Procedure for Phase Extension (1997)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 53 (1997), S. 49-55 
    Details
    ISSN: 1399-0047
    Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Thema: Chemie und Pharmazie , Geologie und Paläontologie , Physik
    Notizen: A procedure combining direct methods and solvent flattening to break the phase ambiguity intrinsic to the single isomorphous replacement (SIR) technique has been tested with the experimental SIR data of the known protein RNase Sa at 2.5 Å resolution. The use of direct methods provided better initial phases for the solvent-flattening procedure, while the solvent-flattening procedure greatly improved direct-method phases leading to a traceable Fourier map. A small subset of known phases at low resolution makes direct phasing of SIR data much easier. Accordingly a method for extending low-resolution phases to high-resolution ones is proposed making use of additional SIR information. This reduces the problem of finding a value in the range of 0–2π for each unknown phase to that of just making a choice between two possible values. Tests with the known protein RNase Sa showed that the method is able to extend phases from a resolution of 6 to 2.5 Å leading to an easily traceable Fourier map. The solvent-flattening technique and the combination of which with direct methods were used for the phase extension. Either procedure yielded reasonably good results, but on the whole, the result from the combination of direct methods with solvent flattening is better. Results of the latter procedure were further compared with that from direct phasing of the 2.5 Å SIR data and with that from phase extension by solvent flattening without SIR information. An improvement gained by the use of SIR information is evident.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1107/S0907444996009365
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  • 4
    Digitale Medien
    Digitale Medien
    Direct-Space Methods in Phase Extension and Phase Refinement. V. The Histogram Moments Method (1996)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 52 (1996), S. 1114-1118 
    Details
    ISSN: 1399-0047
    Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Thema: Chemie und Pharmazie , Geologie und Paläontologie , Physik
    Notizen: Any distribution is completely defined by its moments. It is shown that a process of phase refinement can be carried out, based on Fourier transforms, which modifies the moments of electron density, separately in the protein and solvent regions, towards target values. Tests have been carried out on two moderate-sized proteins with 800–900 atoms in the asymmetric unit, one containing heavy atoms and the other not. It has been found that refinement using the third moment about zero in the protein region is most effective and that refinement with higher moments, or in the solvent region, adds nothing useful. Two kinds of weights are necessary in the method. One is for giving a weighted mixture of new phase indications with original phase estimates from, say, multiple isomorphous replacement. The other weights are applied to the Fourier coefficients of density maps to give the best possible signal:noise ratio. These weights have been explored empirically and the best ones found are described. It is concluded that since the moments method, which changes phases in reciprocal space, is independent of other histogram-matching procedures, which change density in real space, it has something to offer in a refinement package containing several procedures.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1107/S0907444996008451
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  • 5
    Digitale Medien
    Digitale Medien
    A new iterative procedure for combining direct methods with solvent flattening – dealing with the phase ambiguity in protein crystallography (1997)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 53 (1997), S. 792-794 
    Details
    ISSN: 1399-0047
    Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Thema: Chemie und Pharmazie , Geologie und Paläontologie , Physik
    Notizen: A new procedure for combining direct methods with the solvent-flattening technique is proposed for phasing single isomorphous replacement (SIR) or one-wavelength anomalous scattering (OAS) data of proteins. The new procedure differs from the previous one [Zheng, Zheng, Gu, Mo, Fan & Hao (1997). Acta Cryst. D53, 49–55] in that the direct method not only provides input phases to but also accepts feedback phases from solvent flattening, thus forming an iterative process for breaking the ambiguities and refining the values of phases. The new procedure was tested with the experimental SIR data of the known structure ribonuclease Sa. For the strongest 1000 of the total 7264 refelctions, the mean Fobs-weighted phase error is 7.5 and 9.4° lower than that of the previous procedure and that of solvent flattening alone, respectively.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1107/S090744499700680X
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  • 6
    Digitale Medien
    Digitale Medien
    Crystallization and preliminary X-ray diffraction studies of recombinant staphylokinase (1996)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 52 (1996), S. 564-565 
    Details
    ISSN: 1399-0047
    Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Thema: Chemie und Pharmazie , Geologie und Paläontologie , Physik
    Notizen: Staphylokinase, a fibrin-specific plasminogen activator, was highly expressed in Escherichia coli and purified by ion-exchange and gel-filtration chromatography. The purified recombinant staphylokinase was fully active and readily crystallized against 1.2 M sodium citrate in 100 mM Tris–HCl buffer at pH 8.0 using the hanging-drop method. Crystals of staphylokinase diffract to better than 2.2 Å resolution. The crystal belongs to the tetragonal space group P41212 or its enantiomorph with unit-cell parameters a = b = 67.5, c = 150.1 Å. There are two molecules in the asymmetric unit. In this paper, we described the first crystallization of a kind of plasminogen activator and present the results of preliminary X-ray diffraction data from the native protein.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1107/S0907444995013552
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  • 7
    Digitale Medien
    Digitale Medien
    Magnetic properties of Fe/Pd multilayers grown by electron-beam evaporation (1995)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 77 (1995), S. 3965-3970 
    Details
    ISSN: 1089-7550
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: The magnetic properties of [Fe(20 A(ring))/Pd(x A(ring))]25 multilayers prepared by ultrahigh vacuum electron-beam evaporation are presented. It is found that the crystal structure of Fe layers change from bcc to fcc when the thickness of Pd layers dPd≥36 A(ring). The saturation magnetization per unit Fe volume at 5 K is enhanced and oscillates with the increment of the thickness of Pd layers, due to the polarization of Pd atoms. The magnetic hysteresis loops of samples indicate low coercive forces, and ferromagnetic coupling between the Fe layers for all Pd thicknesses (6–60 A(ring)). The conversion electron Mössbauer spectra measurements proved that the magnetic moment of fcc Fe is the same as that of the bcc Fe. It is also found that the magnetic anisotropy dependence on dPd is similar to that of the saturation magnetization, and relates to the Fe layer structure transition. The Curie temperature of Fe/Pd multilayers decreases monotonously with the increasing of dPd. The low temperature magnetization measurement of Fe/Pd multilayers suggests that the interlayer coupling between Fe layers and polarization of Pd layers influences the temperature dependence of saturation magnetization. No evidence of antiferromagnetic coupling between Fe layers and giant magnetoresistance effect is found. The relationship among structure, polarization of Pd layers, and magnetic coupling is discussed. © 1995 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.358579
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  • 8
    Digitale Medien
    Digitale Medien
    Orange-green emission from porous Si coated with Ge films: The role of Ge-related defects (1999)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 86 (1999), S. 707-709 
    Details
    ISSN: 1089-7550
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: Photoluminescence (PL) spectra of porous Si (PS) coated with Ge films were examined using the 514.5 nm line of Ar+ laser. A new orange-green PL band, centered at 2.25 eV, was observed with full-width at half-maximum of ∼0.1 eV, in addition to the reported PL bands at 3.1, 2.0, and 1.72 eV. With increasing the thickness of Ge layer coated, the new PL band remains unchanged in peak energy but drops abruptly in intensity. Spectral analysis and some experimental results from Raman scattering and x-ray diffraction indicate that Ge-related defects at the interfaces between PS and the Ge nanocrystals embedded in the pores are responsible for the orange-green PL band. © 1999 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.370790
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  • 9
    Digitale Medien
    Digitale Medien
    Charge-separated state in strain-induced quantum dots (1997)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 70 (1997), S. 1733-1735 
    Details
    ISSN: 1077-3118
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: We have measured the time-resolved photoluminescence of strain-induced quantum dots. We show that a long-lived intermediate state is involved in the excitation transfer from the interstitial quantum well to the dot. This intermediate state has the properties expected of the charge separated state predicted by theory. © 1997 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.118684
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  • 10
    Digitale Medien
    Digitale Medien
    Oscillatory magnetic interlayer exchange coupling in Fe–N/TiN multilayers (1996)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 68 (1996), S. 2887-2889 
    Details
    ISSN: 1077-3118
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: The discovery of oscillatory interlayer exchange coupling in a new type of ceramic superlattice system Fe–N/TiN, is reported. The magnitude of the exchange coupling was found to oscillate with the thickness of the TiN spacer layer and Fe–N ferromagnetic layer with periods about 0.8 and 0.6 nm, respectively. © 1996 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.116321
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