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  • 1
    Monographie ausleihbar
    Monographie ausleihbar
    New York [u.a.] : McGraw-Hill
    Signatur: G 5373
    Materialart: Monographie ausleihbar
    Seiten: vii, 248 S.
    Sprache: Englisch
    Standort: Kompaktmagazin oben
    Zweigbibliothek: GFZ Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Pharmaceutical chemistry. ; Pharmacology. ; Clinical biochemistry. ; Pharmaceutics. ; Pharmacology. ; Medical Biochemistry.
    Beschreibung / Inhaltsverzeichnis: Route-Specific Challenges in the Delivery of Poorly Water-Soluble Drugs -- Optimizing the Formulation of Poorly Water-Soluble Drugs -- Solid-State Techniques for Improving Solubility -- Mechanical Particle-Size Reduction Techniques -- Co-solvent and Complexation Systems -- Injectable Formulations of Poorly Water-Soluble Drugs -- Lipid-Based Formulations -- Structured Development Approach for Amorphous Systems -- Melt Extrusion -- Spray-Drying Technology -- Pharmaceutical Cryogenic Technologies -- Precipitation Technologies for Nanoparticle Production -- Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs -- Scientific and Regulatory Considerations for Development and Commercialization of Poorly Water-Soluble Drugs.
    Kurzfassung: The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop. Highlights the most recent advancements reported in the literature on technologies to improve the dissolution and bioavailability of poorly water soluble drugs Provides a comprehensive discussion of new technologies developed and recently over 40% updated new content Essential read for scientists and researchers in pharmaceutical, chemical, and agricultural industries since over 80% of newly discovered drugs are poorly water soluble.
    Materialart: Online-Ressource
    Seiten: XII, 693 p. 280 illus., 138 illus. in color. , online resource.
    Ausgabe: 3rd ed. 2022.
    ISBN: 9783030887193
    Serie: AAPS Advances in the Pharmaceutical Sciences Series, 50
    DDC: 615.19
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Food science. ; Nutrition   . ; Food Studies. ; Food Science. ; Nutrition.
    Beschreibung / Inhaltsverzeichnis: Introduction -- Avocados -- Bush Berries -- Chocolate -- Coffee -- Dark Leafy Greens -- Fermented Milk Products -- Ginger -- Oily fish -- Seeds -- Tea -- Tree Berries -- Tubers -- Wine and Grapes. .
    Kurzfassung: Superfoods have come to the forefront of the public imagination due to a combination of presumed health benefits and cultural mystique. Much of the literature on these foods, however, is based upon rostrums and diet plans that accept the health claims of superfoods without subjecting them to rigorous scrutiny. Superfoods: Cultural and Scientific Perspectives examines these food products from a blended science and cultural viewpoint, presenting a balanced, evidence-based view of each food item. Following a discussion of “superfoods” as a category, the book’s chapters examine individual superfoods, including but not limited to: avocados, chocolate, wine, berries, and fish oil. Presented in a systemic manner, each chapter provides a cultural history of the superfood; a survey of the current state of nutritional research on the food and its health claims; an exploration of related science topics to enhance understanding of the superfood, (i.e., a survey of the botany, biology, or chemistry studies); social issues associated with the superfood, such as sustainability, environmental health concerns, agricultural issues, fair trade and marketing issues; and one to three recipes featuring the superfood. This combination of scientific and cultural perspectives makes Superfoods an invaluable reference for academics, industry professionals, and lay-readers alike. .
    Materialart: Online-Ressource
    Seiten: VIII, 214 p. 79 illus., 73 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030932404
    Serie: Food and Health,
    DDC: 641.3
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Evolution (Biology). ; Biodiversity. ; Paleontology . ; Microbiology. ; Biology Technique. ; Evolutionary Biology. ; Biodiversity. ; Paleontology. ; Microbiology. ; Experimental Organisms.
    Beschreibung / Inhaltsverzeichnis: 1. Introduction -- 2. The controversial Cope’s, Haeckel’s and Dollo’s rules.-3. Impact of the environmental stress on the Late Permian pollen grains from Zechstein deposits of Poland -- 4. Stress-related evolution in Triassic conodonts and the Middle Norian juvenile mortality -- 5. Morphogenesis, reverse evolution and environmental stress: The Case of early Triassic Conodonts -- 6. Developmental plasticity induced by either external or internal environment co-opts ancient regulatory networks -- 7. Extreme Morphological Plasticity within Orbulina-"Praeorbulina-Like" assemblages related to environmental Stress -- 8. Steps of morphogenesis and iterative evolution of Imperforate Larger Foraminifera in shallow carbonate shelves during Mesozoic times – possible relations to symbiotic and abiotic factors -- 9. Morphological deformation of foraminiferal tests caused by intertidal oil spills (black tides) -- 10. Environmental Control on Biotic Development in Siberia (Verkhoyansk Region) and Neighboring Areas During Permian–Triassic Large Igneous Province Activity -- 11. Stress, Development, and Evolution in Coral Reef Communities -- 12. Fossil benthic foraminifera morphologic adaptation (kleptoplastidy) within low oxygen bottom water environments, coupled with geochemical insights from the Upper Cretaceous in the Levant Basin -- 13. Evolution as a Timeless Continuum -- 14. Chronic Disease as Reverse Evolution.
    Kurzfassung: It is widely acknowledged that life has adapted to its environment, but the precise mechanism remains unknown since Natural Selection, Descent with Modification and Survival of the Fittest are metaphors that cannot be scientifically tested. In this unique text invertebrate and vertebrate biologists illuminate the effects of physiologic stress on epigenetic responses in the process of evolutionary adaptation from unicellular organisms to invertebrates and vertebrates, respectively. This book offers a novel perspective on the mechanisms underlying evolution. Capacities for morphologic alterations and epigenetic adaptations subject to environmental stresses are demonstrated in both unicellular and multicellular organisms. Furthermore, the underlying cellular-molecular mechanisms that mediate stress for adaptation will be elucidated wherever possible. These include examples of ‘reverse evolution’ by Professor Guex for Ammonites and for mammals by Professor Torday and Dr. Miller. This provides empirical evidence that the conventional way of thinking about evolution as unidirectional is incorrect, leaving open the possibility that it is determined by cell-cell interactions, not sexual selection and reproductive strategy. Rather, the process of evolution can be productively traced through the conservation of an identifiable set of First Principles of Physiology that began with the unicellular form and have been consistently maintained, as reflected by the return to the unicellular state over the course of the life cycle.
    Materialart: Online-Ressource
    Seiten: VI, 322 p. 105 illus., 40 illus. in color. , online resource.
    Ausgabe: 1st ed. 2020.
    ISBN: 9783030472795
    DDC: 576.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Evolution (Biology). ; Biology Philosophy. ; Developmental biology. ; Physiology. ; Genetics. ; Biochemistry. ; Evolutionary Biology. ; Philosophy of Biology. ; Developmental Biology and Stem Cells. ; Physiology. ; Genetics and Genomics. ; Biochemistry.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction -- Chapter 2. Darwin, the Modern Synthesis, and a New Biology -- Chapter 3. Cognition and the living condition -- Chapter 4. What is consciousness? An Evolutionary Perspective -- Chapter 5. Networking from the Cell to Quantum Mechanics as Consciousness -- Chapter 6. The Nature of information and its communication -- Chapter 7. The information cycle and biological information management -- Chapter 8. Communication and the accumulation of genetic information -- Chapter 9. Non-genic means of information reception and exchange -- Chapter 10. The primacy of the unicellular state -- Chapter 11. Phenotype, niche construction and natural cellular engineering -- Chapter 12. Holobionts -- Chapter 13. Four Domains: Cognition-based evolution -- Chapter 14. Reconciling physics and biology -- Chapter 15. What does this mean for evolution? -- Chapter 16. Conclusion: Cellular-molecular evolution in the 21st century. .
    Kurzfassung: There has been no mechanistic explanation for evolutionary change consistent with phylogeny in the 150 years since the publication of ‘Origins’. As a result, progress in the field of evolutionary biology has stagnated, relying on descriptive observations and genetic associations rather testable scientific measures. This book illuminates the need for a larger evolutionary-based platform for biology. Like physics and chemistry, biology needs a central theory in order to frame the questions that arise, the way hypotheses are tested, and how to interpret the data in the context of a continuum.The reduction of biology to its self-referential, self-organized properties provides the opportunity to recognize the continuum from the Singularity/Big Bang to Consciousness based on cell-cell communication for homeostasis.
    Materialart: Online-Ressource
    Seiten: XV, 214 p. 10 illus., 7 illus. in color. , online resource.
    Ausgabe: 1st ed. 2020.
    ISBN: 9783030381332
    DDC: 576.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Monographie ausleihbar
    Monographie ausleihbar
    München : Bayer. Landesstelle für Gewässerkunde
    Dazugehörige Bände
    Signatur: MOP Per 748(10)
    In: Schriftenreihe der Bayerischen Landesstelle für Gewässerkunde
    Materialart: Monographie ausleihbar
    Seiten: X, 32 S. : graph. Darst., Kt. , 30 cm
    Serie: Schriftenreihe der Bayerischen Landesstelle für Gewässerkunde 10
    Standort: MOP - Bitte bestellen
    Zweigbibliothek: GFZ Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Monographie ausleihbar
    Monographie ausleihbar
    Boston, Mass : American Meteorological Society
    Dazugehörige Bände
    Signatur: MOP Per 412(4, 25) ; MOP 4696(4, 25)
    In: Meteorological monographs
    Materialart: Monographie ausleihbar
    Seiten: V, 54 S.
    ISBN: 0933876130
    Serie: Meteorological monographs 4, 25
    Standort: MOP - Bitte bestellen
    Standort: MOP - Bitte bestellen
    Zweigbibliothek: GFZ Bibliothek
    Zweigbibliothek: GFZ Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Schriftenreihen ausleihbar
    Schriftenreihen ausleihbar
    Dazugehörige Bände
    Signatur: ZSP-282-4
    In: Filchner Ronne ice shelf programme
    Beschreibung / Inhaltsverzeichnis: Report No. 4 of the Filchner Ronne Ice Shelf Programme (FRISP) contains summaries of papers presented at three meetings, held in Oslo in 1988, Bremerhaven in 1989 and Cambridge in 1990.
    Materialart: Schriftenreihen ausleihbar
    Seiten: 135 S. : Ill., graph. Darst.
    Zweigbibliothek: AWI Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Monographie ausleihbar
    Monographie ausleihbar
    Washington, DC : National Aeronautics and Space Admin.
    Dazugehörige Bände
    Signatur: MOP 42898 / Mitte
    In: NASA contractor report
    Materialart: Monographie ausleihbar
    Seiten: 26 S. : Ill.
    Serie: NASA contractor report 62081
    Standort: MOP - Bitte bestellen
    Zweigbibliothek: GFZ Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Monographie ausleihbar
    Monographie ausleihbar
    Washington, DC. : U.S. Weather Bureau
    Dazugehörige Bände
    Signatur: MOP Per 350(52)
    In: Technical paper
    Materialart: Monographie ausleihbar
    Seiten: ii, 30 S. : Ill.
    Serie: Technical paper / US Weather Bureau 52
    Standort: MOP - Bitte bestellen
    Zweigbibliothek: GFZ Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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