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Digitale Medien

Effects of sulfur dioxide in air on the fruit fly, Drosophila melanogaster (1978)

Ginevan, Michael E. ; Lane, Dennis D.

s.l. : American Chemical Society

Environmental science & technology 12 (1978), S. 828-831

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ISSN: 1520-5851

Quelle: ACS Legacy Archives

Thema: Chemie und Pharmazie , Energietechnik

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1021/es60143a001

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2

Digitale Medien

Use of Environmental Tobacco Smoke Constituents as Markers for Exposure (1999)

LaKind, Judy S. ; Jenkins, Roger A. ; Naiman, Daniel Q. ; [weitere]

Oxford, UK : Blackwell Publishing Ltd

Risk analysis 19 (1999), S. 0

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ISSN: 1539-6924

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Energietechnik

Notizen: The 16-City Study analyzed for gas-phase environmental tobacco smoke (ETS) constituents (nicotine, 3-ethenyl pyridine [3-EP], and myosmine) and for particulate-phase constituents (respirable particulate matter [RSP], ultraviolet-absorbing particulate matter [UVPM], fluorescing particulate matter [FPM], scopoletin, and solanesol). In this second of three articles, we discussthe merits of each constituent as a marker for ETS and report pair-wise comparisons of the markers. Neither nicotine nor UVPM were good predictors for RSP. However, nicotine and UVPM were good qualitative predictors of each other. Nicotine was correlated with other gas-phase constituents. Comparisons between UVPM and other particulate-phase constituents were performed. Its relation with FPM was excellent, with UVPM approximately 11/2 times FPM. The correlation between UVPM and solanesol was good, but the relationship between the two was not linear. The relation between UVPM and scopoletin was not good, largely because of noise in the scopoletin measures around its limit of detection. We considered the relation between nicotine and saliva cotinine, a metabolite of nicotine. The two were highly correlated on the group level. That is, for each cell (smoking home and work, smoking home but nonsmoking work, and so forth), there was high correlation between average cotinine and 24-hour time-weighted average (TWA) nicotine concentrations. However, on the individual level, the correlations, although significant, were not biologically meaningful. A consideration of cotinine and nicotine or 3-EP on a subset of the study whoseonly exposure to ETS was exclusively at work or exclusively at home showed that home exposure was a more important source of ETS than work exposure.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1539-6924.1999.tb00413.x

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Digitale Medien

A Risk Analysis Model of the Relationship Between Beverage Consumption from School Vending Machines and Risk of Adolescent Overweight (2005)

Forshee, Richard A. ; Storey, Maureen L. ; Ginevan, Michael E.

350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Publishing, Inc.

Risk analysis 25 (2005), S. 0

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ISSN: 1539-6924

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Energietechnik

Notizen: Risk analysis is a widely used tool to understand problems in food safety policy, but it is seldom applied to nutrition policy. We propose that risk analysis be applied more often to inform debates on nutrition policy, and we conduct a risk assessment of the relationship of regular carbonated soft drink (RCSD) consumption in schools and body mass index (BMI) as a case study. Data for RCSD consumption in schools were drawn from three data sets: the Continuing Survey of Food Intake by Individuals 1994–1996, 1998 (CSFII), the National Health and Nutrition Examination Survey 1999–2000 (NHANES), and the National Family Opinion (NFO) WorldGroup Share of Intake Panel (SIP) study. We used the largest relationship between RCSD and BMI that was published by prospective observational studies to characterize the maximum plausible relationship in our study. Consumption of RCSD in schools was low in all three data sets, ranging from 15 g/day in NFO-SIP to 60 g/day in NHANES. There was no relationship between RCSD consumption from all sources and BMI in either the CSFII or the NHANES data. The risk assessment showed no impact on BMI by removing RCSD consumption in school. These findings suggest that focusing adolescent overweight prevention programs on RCSD in schools will not have a significant impact on BMI.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1539-6924.2005.00667.x

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Digitale Medien

Exposure to Environmental Tobacco Smoke in the Workplace and the Impact of Away-From-Work Exposure (1999)

LaKind, Judy S. ; Graves, Carol G. ; Ginevan, Michael E. ; [weitere]

Oxford, UK : Blackwell Publishing Ltd

Risk analysis 19 (1999), S. 0

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ISSN: 1539-6924

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Energietechnik

Notizen: Concentrating on exposure in workplaces where smoking occurs, we examined environmental tobacco smoke (ETS)-related concentration data from the 16-City This study.(1,2) This study involved a large population of nonsmokers, used personal monitors, and encompassed a wide selection of ETS-related constituents. This first article in a series of three describes the 16-City Study, considers the impact of demographic variables, and concludes that these variables did not explain differences in exposure to ETS. We compared 16-City Study concentrations obtained in the workplace to previously reported workplace concentrations and determined that data from this study were representative of current ETS exposure in nonmanufacturing workplaces where smoking occurs. Considering factors other than demographic factors, we found that, not surprisingly, the number of cigarettes observed in the workplace had an impact on exposure concentrations. Finally, we compared people from homes where smoking occurs with people from nonsmoking homes and found that people from smoking homes observed more smoking in the workplace and experienced higher concentrations of ETS-related compounds in the workplace, even when they observed the same number of cigarettes being smoked in the workplace. In two subsequent articles in this series, we discuss relationships between various ETS markers and provide estimates of distributions of doses to nonsmoking workers employed in workplaces where smoking occurs.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1539-6924.1999.tb00412.x

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Digitale Medien

Distribution of Exposure Concentrations and Doses for Constituents of Environmental Tobacco Smoke (1999)

LaKind, Judy S. ; Ginevan, Michael E. ; Naiman, Daniel Q. ; [weitere]

Oxford, UK : Blackwell Publishing Ltd

Risk analysis 19 (1999), S. 0

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ISSN: 1539-6924

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Energietechnik

Notizen: The ultimate goal of the research reported in this series of three articles is to derive distributions of doses of selected environmental tobacco smoke (ETS)-related chemicals for nonsmoking workers. This analysis uses data from the 16-City Study collected with personal monitors over the course of one workday in workplaces where smoking occurred. In this article, we describe distributions of ETS chemical concentrations and the characteristicsof those distributions (e.g., whether the distribution was log normal for agiven constituent) for the workplace exposure. Next, we present population parameters relevant for estimating dose distributions and the methods used for estimating those dose distributions. Finally, we derive distributions of doses of selected ETS-related constituents obtained in the workplace for people in smoking work environments. Estimating dose distributions providedinformation beyond the usual point estimate of dose and showed that the preponderance of individuals exposed to ETS in the workplace were exposed at the low end of the dose distribution curve. The results of this analysis include estimations of hourly maxima and time-weighted average (TWA) doses of nicotine from workplace exposures to ETS (extrapolated from 1 day to 1 week) and doses derived from modeled lung burdens of ultraviolet-absorbing particulate matter (UVPM) and solanesol resulting from workplace exposures to ETS (extrapolated from 1 day to 1 year).

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1539-6924.1999.tb00414.x

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6

Digitale Medien

Estimation of Dietary Exposure to Chemicals: A Case Study Illustrating Methods of Distributional Analyses for Food Consumption Data (1996)

Driver, Jeffrey H. ; Ginevan, Michael E. ; Whitmyre, Gary K.

Oxford, UK : Blackwell Publishing Ltd

Risk analysis 16 (1996), S. 0

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ISSN: 1539-6924

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Energietechnik

Notizen: There are a number of sources of variability in food consumption patterns and residue levels of a particular chemical (e.g., pesticide, food additive) in commodities that lead to an expected high level of variability in dietary exposures across a population. This paper focuses on examples of consumption pattern survey data for specific commodities, namely that for wine and grape juice, and demonstrates how such data might be analyzed in preparation for performing stochastic analyses of dietary exposure. Data from the NIAAA/NHIS wine consumption survey were subset for gender and age group and, with matched body weight data from the survey database, were used to define empirically-based percentile estimates for wine intake (μl wine/kg body weight) for the strata of interest. The data for these two subpopulations were analyzed to estimate 14-day consumption distributional statistics and distributions for only those days on which wine was consumed. Data subsets for all wine-consuming adults and wine-consuming females ages 18 through 45, were determined to fit a lognormal distribution (R2= 0.99 for both datasets). Market share data were incorporated into estimation of chronic exposures to hypothetical chemical residues in imported table wine. As a separate example, treatment of grape juice consumption data for females, ages 18–40, as a simple lognormal distribution resulted in a significant underestimation of intake, and thus exposure, because the actual distribution is a mixture (i.e., multiple subpopulations of grape juice consumers exist in the parent distribution). Thus, deriving dietary intake statistics from food consumption survey data requires careful analysis of the underlying empirical distributions.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1539-6924.1996.tb00827.x

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7

Digitale Medien

Use of Environmental Tobacco Smoke Constituents as Markers for Exposure (1999)

LaKind, Judy S. ; Jenkins, Roger A. ; Naiman, Daniel Q. ; [weitere]

Springer

Risk analysis 19 (1999), S. 359-373

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ISSN: 1539-6924

Schlagwort(e): 16-City Study ; environmental tobacco smoke ; markers ; nicotine ; personal monitoring ; saliva cotinine ; workplace exposure

Quelle: Springer Online Journal Archives 1860-2000

Thema: Energietechnik

Notizen: Abstract The 16-City Study analyzed for gas-phase environmental tobacco smoke (ETS) constituents (nicotine, 3-ethenyl pyridine [3-EP], and myosmine) and for particulate-phase constituents (respirable particulate matter [RSP], ultraviolet-absorbing particulate matter [UVPM], fluorescing particulate matter [FPM], scopoletin, and solanesol). In this second of three articles, we discuss the merits of each constituent as a marker for ETS and report pair-wise comparisons of the markers. Neither nicotine nor UVPM were good predictors for RSP. However, nicotine and UVPM were good qualitative predictors of each other. Nicotine was correlated with other gas-phase constituents. Comparisons between UVPM and other particulate-phase constituents were performed. Its relation with FPM was excellent, with UVPM approximately 1 1/2 times FPM. The correlation between UVPM and solanesol was good, but the relationship between the two was not linear. The relation between UVPM and scopoletin was not good, largely because of noise in the scopoletin measures around its limit of detection. We considered the relation between nicotine and saliva cotinine, a metabolite of nicotine. The two were highly correlated on the group level. That is, for each cell (smoking home and work, smoking home but nonsmoking work, and so forth), there was high correlation between average cotinine and 24-hour time-weighted average (TWA) nicotine concentrations. However, on the individual level, the correlations, although significant, were not biologically meaningful. A consideration of cotinine and nicotine or 3-EP on a subset of the study whose only exposure to ETS was exclusively at work or exclusively at home showed that home exposure was a more important source of ETS than work exposure.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1023/A:1007088209811

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8

Digitale Medien

Exposure to Environmental Tobacco Smoke in the Workplace and the Impact of Away-From-Work Exposure (1999)

LaKind, Judy S. ; Graves, Carol G. ; Ginevan, Michael E. ; [weitere]

Springer

Risk analysis 19 (1999), S. 349-358

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ISSN: 1539-6924

Schlagwort(e): 16-City Study ; avoidance ; environmental tobacco smoke (ETS) ; personal monitoring ; workplace exposure

Quelle: Springer Online Journal Archives 1860-2000

Thema: Energietechnik

Notizen: Abstract Concentrating on exposure in workplaces where smoking occurs, we examined environmental tobacco smoke (ETS)-related concentration data from the 16-City Study.(1,2) This study involved a large population of nonsmokers, used personal monitors, and encompassed a wide selection of ETS-related constituents. This first article in a series of three describes the 16-City Study, considers the impact of demographic variables, and concludes that these variables did not explain differences in exposure to ETS. We compared 16-City Study concentrations obtained in the workplace to previously reported workplace concentrations and determined that data from this study were representative of current ETS exposure in nonmanufacturing workplaces where smoking occurs. Considering factors other than demographic factors, we found that, not surprisingly, the number of cigarettes observed in the workplace had an impact on exposure concentrations. Finally, we compared people from homes where smoking occurs with people from nonsmoking homes and found that people from smoking homes observed more smoking in the workplace and experienced higher concentrations of ETS-related compounds in the workplace, even when they observed the same number of cigarettes being smoked in the workplace. In two subsequent articles in this series, we discuss relationships between various ETS markers and provide estimates of distributions of doses to nonsmoking workers employed in workplaces where smoking occurs.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1023/A:1007036225741

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Digitale Medien

Distribution of Exposure Concentrations and Doses for Constituents of Environmental Tobacco Smoke (1999)

LaKind, Judy S. ; Ginevan, Michael E. ; Naiman, Daniel Q. ; [weitere]

Springer

Risk analysis 19 (1999), S. 375-390

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ISSN: 1539-6924

Schlagwort(e): 16-City Study ; distributional analysis ; dose distributions ; environmental tobacco smoke ; Monte Carlo ; nicotine ; solanesol ; ultraviolet-absorbing particulate matter ; workplace exposure

Quelle: Springer Online Journal Archives 1860-2000

Thema: Energietechnik

Notizen: Abstract The ultimate goal of the research reported in this series of three articles is to derive distributions of doses of selected environmental tobacco smoke (ETS)-related chemicals for nonsmoking workers. This analysis uses data from the 16-City Study collected with personal monitors over the course of one workday in workplaces where smoking occurred. In this article, we describe distributions of ETS chemical concentrations and the characteristics of those distributions (e.g., whether the distribution was log normal for a given constituent) for the workplace exposure. Next, we present population parameters relevant for estimating dose distributions and the methods used for estimating those dose distributions. Finally, we derive distributions of doses of selected ETS-related constituents obtained in the workplace for people in smoking work environments. Estimating dose distributions provided information beyond the usual point estimate of dose and showed that the preponderance of individuals exposed to ETS in the workplace were exposed at the low end of the dose distribution curve. The results of this analysis include estimations of hourly maxima and time-weighted average (TWA) doses of nicotine from workplace exposures to ETS (extrapolated from 1 day to 1 week) and doses derived from modeled lung burdens of ultraviolet-absorbing particulate matter (UVPM) and solanesol resulting from workplace exposures to ETS (extrapolated from 1 day to 1 year).

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1023/A:1007040326649

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