Publikationsdatum:
2017-12-15
Beschreibung:
Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer, Published online: 14 December 2017; doi:10.1038/s41467-017-02186-9 Tumor-associated dendritic cells are defective in their ability to cross-present antigens, and they accumulate lipid bodies. Here the authors show that this defect is due to an impaired trafficking of peptide-MHC class I caused by the interaction of electrophilic lipids with chaperone heat shock protein 70.
Digitale ISSN:
2041-1723
Thema:
Biologie
,
Chemie und Pharmazie
,
Allgemeine Naturwissenschaft
,
Physik
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