ISSN:
1420-9071
Keywords:
Structured analysis
;
mathematical modelling
;
stochastic simulation
;
cell cycle control
;
tumor biology
;
calcium oscillations
;
signal transduction
;
Structured Biological Modelling
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract In this paper we introduce a systematic approach for the modelling of complex biological systems which is especially useful for the analysis of signal transduction mechanisms in cell biology. It is shown that systems analysis in form of top-down levelled dataflow diagrams provides a powerful tool for the mathematical modelling of the system in terms of a stochastic formulation. Due to the exact formulation, the consistency of the model with the experimental results can be tested by means of a computer simulation. The method termed Structured Biological Modelling (SBM) is illustrated by modelling some aspects of the second messenger network which regulates cell proliferation. As an example for the strainghtforward development of a mathematical description a stochastic computer model for intracellular Ca2+ oscillations is presented.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01923534
Permalink
