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  • Articles  (4)
  • Biology  (4)
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  • Articles  (4)
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  • 1
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    S-nitrosylation of AMPAR regulates its function [Neuroscience] (2013)
    National Academy of Sciences
    Details
    Publication Date: 2013-01-16
    Description: NMDA receptor activation can elicit synaptic plasticity by augmenting conductance of the AMPA receptor GluA1 subsequent to phosphorylation at S831 by Ca2+-dependent kinases. NMDA receptor activation also regulates synaptic plasticity by causing endocytosis of AMPA receptor GluA1. We demonstrate a unique signaling cascade for these processes mediated by NMDA receptor-dependent...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-11-26
    Description: Ghrelin is a gastric peptide hormone that stimulates weight gain in vertebrates. The biological activities of ghrelin require octanoylation of the peptide on Ser(3), an unusual posttranslational modification that is catalyzed by the enzyme ghrelin O-acyltransferase (GOAT). Here, we describe the design, synthesis, and characterization of GO-CoA-Tat, a peptide-based bisubstrate analog that antagonizes GOAT. GO-CoA-Tat potently inhibits GOAT in vitro, in cultured cells, and in mice. Intraperitoneal administration of GO-CoA-Tat improves glucose tolerance and reduces weight gain in wild-type mice but not in ghrelin-deficient mice, supporting the concept that its beneficial metabolic effects are due specifically to GOAT inhibition. In addition to serving as a research tool for mapping ghrelin actions, GO-CoA-Tat may help pave the way for clinical targeting of GOAT in metabolic diseases.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068526/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068526/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barnett, Brad P -- Hwang, Yousang -- Taylor, Martin S -- Kirchner, Henriette -- Pfluger, Paul T -- Bernard, Vincent -- Lin, Yu-yi -- Bowers, Erin M -- Mukherjee, Chandrani -- Song, Woo-Jin -- Longo, Patti A -- Leahy, Daniel J -- Hussain, Mehboob A -- Tschop, Matthias H -- Boeke, Jef D -- Cole, Philip A -- P01 CA016519/CA/NCI NIH HHS/ -- P01 CA016519-35/CA/NCI NIH HHS/ -- P30 DK079637/DK/NIDDK NIH HHS/ -- P60 DK079637/DK/NIDDK NIH HHS/ -- P60 DK079637-05/DK/NIDDK NIH HHS/ -- R01 DK081472/DK/NIDDK NIH HHS/ -- R01 DK081472-01A1/DK/NIDDK NIH HHS/ -- R01 DK081472-02/DK/NIDDK NIH HHS/ -- R01 DK081472-03/DK/NIDDK NIH HHS/ -- R01 GM062437/GM/NIGMS NIH HHS/ -- R01 GM062437-04/GM/NIGMS NIH HHS/ -- R01 GM062437-11/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2010 Dec 17;330(6011):1689-92. doi: 10.1126/science.1196154. Epub 2010 Nov 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21097901" target="_blank"〉PubMed〈/a〉
    Keywords: Acylation ; Acyltransferases/*antagonists & inhibitors ; Animals ; Cell Survival/drug effects ; Drug Design ; Enzyme Inhibitors/chemical synthesis/*pharmacology/toxicity ; Ghrelin/deficiency/genetics/*metabolism ; Glucose/*metabolism ; Glucose Tolerance Test ; HeLa Cells ; Homeostasis ; Humans ; Insulin/metabolism ; Ion Channels/metabolism ; Islets of Langerhans/drug effects/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondrial Proteins/metabolism ; Peptides/chemical synthesis/*pharmacology/toxicity ; Weight Gain/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    Population characteristics of green tiger prawns, Penaeus semisulcatus, in Kuwait waters prior to the Gulf War (1996)
    Springer
    Hydrobiologia 337 (1996), S. 37-47 
    Details
    ISSN: 1573-5117
    Keywords: exploitation rate ; recruitment ; mortality ; growth ; sex ratios
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Monthly length-frequency data of green tiger prawns from April 1985 to August 1990 were analyzed to estimate the von Bertalanffy growth curves and related parameters. The mean asymptotic carapace lengths (L ∞) and growth constants (K) over 5 seasons were 36.6 mm and 1.6 yr−1 for males and 51.2 mm and 1.7 yr−1 for females, respectively. Annual total mortality rates (Z) from 1985/86 to 1989/90 ranged from 2.7 to 6.5 yr−1 for males and from 2.8 to 6.8 yr−1 1 for females. The mean exploitation rates calculated using the mean natural mortality rates (M) of 2.5 yr−1 for males and 2.4 yr−1 for females showed that the male green tiger prawns in Kuwait waters were under exploited, whereas the catch of females was very close to the sustainable yield. Chi-square tests indicated that the sex ratio was close to one for adults (CL ≽ 26 mm), but significantly favoured males for recruits (CL 〈 26 mm). A major recruitment was detected from June/July in all seasons and a minor recruitment in some seasons in August/September. The relative yield-per-recruit (Y'/R) reached the optimum at the length-at-first capture (L c) of 25 mm CL for males, and increased as L c increased for females. The observed mean L c, values were 23.4 mm for both males and females. The Y'/R under the current exploitation level is close to the maximum sustainable yield for females, but lower for males. More fishing effort could be exerted to exploit males, but doing so may not be biologically or commercially possible with current trawling practices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00028505
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    Paper (German National Licenses)
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  • 4
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    Population characteristics of green tiger prawns, Penaeus semisulcatus, in Kuwait waters prior to the Gulf War (1996)
    Springer
    Details
    Publication Date: 1996-11-01
    Print ISSN: 0018-8158
    Electronic ISSN: 1573-5117
    Topics: Biology
    Published by Springer
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