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  • Articles  (112)
  • Chemistry and Pharmacology  (108)
  • Process Engineering, Biotechnology, Nutrition Technology  (19)
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  • Articles  (112)
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  • 1
    Electronic Resource
    Electronic Resource
    Origin of the structure in M-H-M vibrational modes of decacarbonylhydroditungstate(1-) (1979)
    s.l. : American Chemical Society
    Inorganic chemistry 18 (1979), S. 1407-1408 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic50195a055
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  • 2
    Electronic Resource
    Electronic Resource
    Transport of K+ and other cations across phospholipid membranes by nonesterified fatty acids (1994)
    Springer
    The journal of membrane biology 141 (1994), S. 21-28 
    Details
    ISSN: 1432-1424
    Keywords: Fatty acids ; Liposomes ; Cation transport ; Membrane transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The rate of change of internal pH and transmembrane potential has been monitored in liposomes following the external addition of various cation salts. Oleic acid increases the transmembrane movement of H+ following the imposition of a K+ gradient. An initial fast change in internal pH is seen followed by a slower rate of alkalinization. High concentrations of the fatty acid enhance the rate comparable to that seen in the presence of nigericin in contrast to the effect of FCCP (carbonyl cyanide p-(tri-fluoromethoxy)phenyl hydrazone) which saturates at an intermediate value. The ability of nonesterified fatty acids to catalyze the movement of cations across the liposome membrane increases with the degree of unsaturation and decreases with increasing chain length. Li and Na salts cause a similar initial fast pH change but have less effect on the subsequent slower rate. Similarly, the main effect of divalent cation salts is on the initial fast change. The membrane potential can enhance or inhibit cation transport depending on its polarity with respect to the cation gradient. It is concluded that nonesterified fatty acids have the capability to complex with, and transport, a variety of cations across phospholipid bilayers. However, they do not act simply as proton/cation exchangers analogous to nigericin nor as protonophores analogous to FCCP. The full cycle of ionophoric action involves a combination of both functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00232870
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  • 3
    Electronic Resource
    Electronic Resource
    Personality and theophylline pharmacokinetics (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 429-431 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; asthma ; personality measures ; pharmacokinetics ; volunteers ; patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Thirteen volunteers received an iv dose of theophylline followed by blood sampling for 8 h to calculate pharmacokinetic parameters. Ten patients with asthma undergoing chronic dosing with slow release aminophylline underwent 12 h of blood sampling to calculate theophylline clearance. Both groups completed an Eysenck Personality Inventory (EPI) from which was derived scores for neuroticism (N) and extroversion (E). Using multiple regression analysis no independent effect of either N or E score on theophylline clearance or half-life could be demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544362
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  • 4
    Electronic Resource
    Electronic Resource
    The disposition of inhaled lysine theophylline in volunteers (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 635-637 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; inhalation ; saliva-serum distribution ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Six healthy volunteers received an iv infusion of 317 mg lysine theophylline (equivalent to 197 mg anhydrous theophylline) in order to calculate theophylline clearance by standard methods. They subsequently received a 20 minute inhalation of nebulised lysine theophylline. Serum and salivary theophylline concentrations were measured and all saliva was collected for the first hour. From these concentrations estimates were made of the distribution of theophylline into the blood and saliva with 40% to 94% identified in the blood. Very high salivary concentrations were reached during the inhalation phase with saliva: serum concentration ratios of between 60 and 1600.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543500
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  • 5
    Electronic Resource
    Electronic Resource
    The relationship between clearance of theophylline and age within the adult age range (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 177-179 
    Details
    ISSN: 1432-1041
    Keywords: theophylline clearance ; age ; adult age range ; normal subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twenty volunteers aged between 20 and 57 years were given 197 mg of theophylline (as lysine theophylline) by iv infusion over 5 minutes to test the hypothesis that within the adult age range theophylline clearance declines with age. Samples were assayed for theophylline using the EMIT assay and clearance was determined by standard methods. Clearance values were 0.73 ml/min/kg below age 38 years and 0.75 ml/min/kg at and above age 38 years. Multiple regression analysis using age as a continuous variable showed no relationship between age and clearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547418
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  • 6
    Electronic Resource
    Electronic Resource
    Capillary Distribution and Fiber Characteristics in Skeletal Muscle of Stress-Susceptible Animals (1969)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 34 (1969), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Muscle from stress-susceptible and stress-resistant pigs was studied for capillary distribution and fiber characteristics. More capillaries were associated with red fibers than white fibers and there was a greater capillary to fiber ratio in red than white muscle. There was no difference in capillary fiber ratio between normal (from stress-resistant pigs) and PSE (from stress-susceptible pigs) muscle. Muscle from stress-susceptible animals had more intermediate fibers than did muscle from stress-resistant animals. Certain intermediate fibers from stress-susceptible animals had a high amylophosphorylase and ATPase activity. It was postulated that such fibers are important in the drastic post-mortem muscle behavior in stress-susceptible animals and may represent the characteristic which causes muscle to become PSE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1969.tb10348.x
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  • 7
    Electronic Resource
    Electronic Resource
    The Oldoway Human Skeleton (1932)
    [s.l.] : Nature Publishing Group
    Nature 129 (1932), S. 312-313 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A LETTER appeared in NATURE of Oct. 24, 1931, signed by Messrs. Leakey, Hopwood, and Reck, in which, among other conclusions, it is stated that “there is no possible doubt that the human skeleton came from Bed No. 2 and not from Bed No. 4”. This must be taken to mean that the skeleton is to be ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/129312b0
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of Thyroxine on the Swelling of Mitochondria isolated from Various Tissues of the Rat (1956)
    [s.l.] : Nature Publishing Group
    Nature 178 (1956), S. 1119-1119 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Not all tissues respond in the same degree to the in vivo administration of thyroxine. Gordon and Heming8 found that the oxygen consumption of slices of liver, kidney, diaphragm and heart from thyrotoxic rats was significantly greater than normal, while that of slices of spleen, brain and testis ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1781119a0
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  • 9
    Electronic Resource
    Electronic Resource
    The Oldoway Human Skeleton (1932)
    [s.l.] : Nature Publishing Group
    Nature 129 (1932), S. 903-903 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] WE are glad to find from Dr. Leakey's letter in NATURE of May 14 that he is in agreement with us in regarding the Oldoway skeleton as an artificial burial, and regret that, in common with everyone else whom we have consulted in this matter, we interpreted his original letter in NATURE of Oct. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/129903a0
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  • 10
    Electronic Resource
    Electronic Resource
    Photoaffinity labelling and phosphorylation of a 165 kilodalton peptide associated with dihydropyridine and phenylalkylamine-sensitive calcium channels
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 147 (1987), S. 1137-1145 
    Details
    ISSN: 0006-291X
    Keywords: [abr] DHP; dihydropyridine ; [abr] SDS; sodium dodecyl sulfate ; [abr] WGA; wheat germ agglutinin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(87)80188-2
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