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  • Articles  (588)
  • Medicine  (566)
  • Natural Sciences in General  (518)
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  • Articles  (588)
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  • 1
    Electronic Resource
    Electronic Resource
    POLYUNSATURATED FATTY ACIDS AND TOCOPHEROL LEVELS IN PATIENTS WITH CYSTIC FIBROSIS (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 203 (1972), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1972.tb27879.x
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  • 2
    Electronic Resource
    Electronic Resource
    Candida glabrata STE12 is required for wild-type levels of virulence and nitrogen starvation induced filamentation (2003)
    Oxford, UK : Blackwell Publishing Ltd.
    Molecular microbiology 50 (2003), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The highly conserved fungal Ste12 transcription factor family of proteins play critical roles in the regulation of many cellular processes including mating, cell wall biosynthesis, filamentation and invasive growth. They are also important mediators of fungal virulence. The Candida glabrata STE12 homologue was cloned. The encoded protein has a single DNA binding homeodomain but lacks both a C2H2 zinc finger DNA binding domain and an apparent Dig1/Dig2 regulatory motif. Candida glabrata STE12 can functionally complement the nitrogen starvation induced filamentation and mating defects of Saccharomyces cerevisiae ste12 mutants. We also show that C. glabrata STE12 is required for nitrogen starvation-induced filamentation as ste12 mutants rarely produce pseudohyphae on nitrogen depeleted media. Finally we describe a novel murine model of C. glabrata systemic disease and use this to demonstrate that C. glabrata ste12 mutants, although still able to cause disease, are attenuated for virulence compared with STE12 reconstituted strains. Candida glabrata STE12 is therefore the first virulence factor encoding gene to be described in this increasingly important fungal pathogen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2958.2003.03755.x
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  • 3
    Electronic Resource
    Electronic Resource
    [Letters to Editor] (1885)
    [s.l.] : Nature Publishing Group
    Nature 33 (1885), S. 152-153 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] WITH reference to Mr. Haslam's remarks (NATURE, December 10, p. 128) as to the coincidence of auroræ with star-showers, I believe that their combined apparitions have no meaning further than that resulting from pure accident. I have seen many rich star-showers without the faintest visible trace ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/033152f0
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  • 4
    Electronic Resource
    Electronic Resource
    The August Meteors (1885)
    [s.l.] : Nature Publishing Group
    Nature 32 (1885), S. 415-415 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] BETWEEN August 4 and 20, 174 shooting stars were recorded here in 1612 hours of observation. These included about 37 Perseids, chiefly seen on August 5, 8, and 13, but the shower was not well observed owing to cloudy weather. The following are ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/032415a0
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  • 5
    Electronic Resource
    Electronic Resource
    July Meteors (1885)
    [s.l.] : Nature Publishing Group
    Nature 32 (1885), S. 342-342 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] BETWEEN July 8 and 14, 111 shooting stars were recorded herein 1134 hours of observation. The paths of these, reproduced upon an 18-inch celestial globe, enabled me to fix the radiant points of 12 showers with considerable distinctness:— ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/032342b0
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  • 6
    Electronic Resource
    Electronic Resource
    Recurrence of Markings on Jupiter (1885)
    [s.l.] : Nature Publishing Group
    Nature 32 (1885), S. 196-197 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN connection with my remarks on this subject (NATURE, xxxii., p. 31), and the suggestive coincidences which appear amongst certain drawings obtained in about the years 1857 and 1859, 1870 and 1872, and 1885, as to large elliptical markings in the southern hemisphere of Jupiter, I would further ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/032196c0
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  • 7
    Electronic Resource
    Electronic Resource
    Fire-ball of August 13–August Meteors (1888)
    [s.l.] : Nature Publishing Group
    Nature 38 (1888), S. 415-415 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A COMPARISON of several good observations of this brilliant visitor shows that the point of its first appearance was over a place near Masham, in Yorkshire, at a height of 79 miles. The disappearance occurred over Gisburn, in the same county, after the meteor had traversed a course of about 48 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/038415a0
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  • 8
    Electronic Resource
    Electronic Resource
    The Red Spot on Jupiter (1888)
    [s.l.] : Nature Publishing Group
    Nature 38 (1888), S. 342-342 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] AN observation with my 10-inch reflector, power 252, on August 5, 1888, showed the red spot passing the planet's central meridian at about 7h. 48m. Comparing this with the first observation I obtained of this object during the present opposition, viz. on December 28, 1887, at 20h. 23m., I find ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/038342c0
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  • 9
    Electronic Resource
    Electronic Resource
    The Meteoric Season (1888)
    [s.l.] : Nature Publishing Group
    Nature 38 (1888), S. 276-276 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] WE have now arrived at a period of the year which is full of interest to meteoric observers. The number of meteors visible has greatly increased, as compared with preceding months, and apart from this, observations may be pursued without the discomfort and inconvenience so often experienced on the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/038276a0
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  • 10
    Electronic Resource
    Electronic Resource
    The Gale (1886)
    [s.l.] : Nature Publishing Group
    Nature 34 (1886), S. 596-596 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IT may be worth mentioning as a curious coincidence that three of the most violent gales of recent times occurred on very nearly the same date of the year, namely:— Sunday, October 14, 1877. Saturday, October 14, 1881. Friday, October 15, 1886. The first of these was the most ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/034596e0
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