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  • 1
    Publication Date: 2013-08-31
    Description: Investigation of radiation induced damage in mutant strains of mammalian cells which show a defect in the rejoining of DNA double strand breaks provides an unique opportunity to examine the role of double strand breaks and the mechanisms of double strand break rejoining in the production of chromosome aberrations. This is particularly important, because there is increasing evidence that the DNA double strand break is the major lesion responsible for the formation of chromosome aberrations. To address this issue, we studied the induction of chromosome aberrations in xrs-5 cells, an x-ray sensitive strain of a Chinese hamster ovary cell line, which shows a defect in the rejoining of double strand breaks and their wild-type parent CHO-cells. Because radiosensitivity depends strongly on cellular age, the experiments were performed with synchronous cells.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: NASA. Ames Research Center, Minutes of the 12th Joint NASA(DARA-DLR Life Sciences Program Working Group Meeting; p 26-27
    Format: application/pdf
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  • 2
    Publication Date: 2023-12-14
    Description: 〈title xmlns:mml="http://www.w3.org/1998/Math/MathML"〉Abstract〈/title〉〈p xmlns:mml="http://www.w3.org/1998/Math/MathML" xml:lang="en"〉The collection of zooplankton swimmers and sinkers in time‐series sediment traps provides unique insight into year‐round and interannual trends in zooplankton population dynamics. These samples are particularly valuable in remote and difficult to access areas such as the Arctic Ocean, where samples from the ice‐covered season are rare. In the present study, we investigated zooplankton composition based on swimmers and sinkers collected by sediment traps at water depths of 180–280, 800–1320, and 2320–2550 m, over a period of 16 yr (2000–2016) at the Long‐Term Ecological Research observatory HAUSGARTEN located in the eastern Fram Strait (79°N, 4°E). The time‐series data showed seasonal and interannual trends within the dominant zooplankton groups including copepoda, foraminifera, ostracoda, amphipoda, pteropoda, and chaetognatha. Amphipoda and copepoda dominated the abundance of swimmers while pteropoda and foraminifera were the most important sinkers. Although the seasonal occurrence of these groups was relatively consistent between years, there were notable interannual variations in abundance, suggesting the influence of various environmental conditions such as sea‐ice dynamic and lateral advection of water masses, for example, meltwater and Atlantic water. Statistical analyses revealed a correlation between the Arctic dipole climatic index and sea‐ice dynamics (i.e., ice coverage and concentration), as well as the importance of the distance from the ice edge on swimmer composition patterns and carbon export.〈/p〉
    Description: Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659
    Description: Federal Ministry of Education and Research (BMBF)
    Description: Helmholtz‐Gemeinschaft
    Keywords: ddc:577.7 ; eastern Fram Strait ; sea ice dynamics ; zooplankton population dynamics
    Language: English
    Type: doc-type:article
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  • 3
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    In:  Geophys. Res. Lett., Basel, Birkhäuser Verlag, vol. 33, no. 19, pp. 1-5, pp. L19303, (ISBN: 0534351875, 2nd edition)
    Publication Date: 2006
    Description: Fluids are known to be of major importance for the earthquake generation because pore pressure variations alter the strength of faults. Thus they can initiate earthquakes if the crust is close enough to its critical state. Based on the observations of the isolated seismicity below the densely monitored Mt. Hochstaufen, SE Germany, we are now able to demonstrate that the crust can be so close-to-failure that even tiny pressure variations associated with precipitation can trigger earthquakes in a few kilometer depth. We find that the recorded seismicity is highly correlated with the calculated spatiotemporal pore pressure changes due to diffusing rain water and in good agreement with the response of faults described by the rate-state friction law.
    Keywords: Fluids ; precipitation ; triggering ; Seismicity ; 7209 ; Seismology: ; Earthquake ; dynamics ; 7215 ; Earthquake ; source ; observations ; 7230 ; Seismicity ; and ; tectonics ; 7223 ; Earthquake ; interaction, ; forecasting, ; and ; prediction ; 8045 ; Structural ; Geology: ; Role ; of ; fluids
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  • 4
    Publication Date: 2011-08-24
    Description: No abstract available
    Keywords: Life Sciences (General)
    Type: Journal of magnetic resonance. Series B (ISSN 1064-1866); Volume 113; 179-83
    Format: text
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  • 5
    Publication Date: 2011-08-24
    Description: BACKGROUND: Previous isolation studies have shown increased 24-h urine volumes and body weight gains in subjects. This project examined those and other physiological variables in relationship to sleep motor activity, subjective sleep quality, mood, and complaints during confinement. METHODS: Six male and two female subjects lived for 7 d in the National Space Development Agency of Japan's isolation chamber, which simulates the interior of the Japanese Experiment Module. Each 24-h period included 6 h of sleep, 3 meals, and 20 min of exercise. Each morning, subjects completed Sleep Sensation and Complaint Index questionnaires. Catecholamine and creatinine excretion, urine volume, and body weight were measured on the 2 d before and 2 d after confinement, and sleep motor activity was measured during confinement. RESULTS: Confinement produced no significant change in body weight, urine volume, or questionnaire results. In contrast, epinephrine, norepinephrine, and sleep motor activity exhibited significant differences during confinement (p 〈 0.05). Higher nocturnal norepinephrine excretion correlated with higher sleep motor activity. CONCLUSION: The 24-h epinephrine values were slightly higher than normal throughout the experiment, but lower than for subjects working under time-stress. High sympathetic activity (as indicated by norepinephrine) may have interfered with sleep.
    Keywords: Behavioral Sciences
    Type: Aviation, space, and environmental medicine (ISSN 0095-6562); Volume 73; 11; 1089-93
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  • 6
    Publication Date: 2011-08-24
    Description: Before long-duration flights with international crews can be safely undertaken, potential interpersonal difficulties will need to be addressed. Crew performance breakdown has been recognized by the American Institute of Medicine, in scientific literature, and in popular culture. However, few studies of human interaction and performance in confined, isolated environments exist, and the data pertaining to those studies are mostly anecdotal. Many incidents involving crew interpersonal dynamics, those among flight crews, as well as between flight crews and ground controllers, are reported only in non-peer reviewed books and newspapers. Consequently, due to this lack of concrete knowledge, the selection of astronauts and cosmonauts has focused on individual rather than group selection. Additional selection criteria such as interpersonal and communication competence, along with intercultural training, will have a decisive impact on future mission success. Furthermore, industrial psychological research has demonstrated the ability to select a group based on compatibility. With all this in mind, it is essential to conduct further research on heterogeneous, multi-national crews including selection and training for long-duration space missions.
    Keywords: Life Sciences (General)
    Type: Aviation, space, and environmental medicine (ISSN 0095-6562); Volume 74; 5; 575-8
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  • 7
    Publication Date: 2004-12-03
    Description: The Software Engineering Laboratory (SEL) has been operating for more than two decades in the Flight Dynamics Division (FDD) and has adapted to the constant movement of the software development environment. The SEL's Improvement Paradigm shows that process improvement is an iterative process. Understanding, Assessing and Packaging are the three steps that are followed in this cyclical paradigm. As the improvement process cycles back to the first step, after having packaged some experience, the level of understanding will be greater. In the past, products resulting from the packaging step have been large process documents, guidebooks, and training programs. As the technical world moves toward more modularized software, we have made a move toward more modularized software development process documentation, as such the products of the packaging step are becoming smaller and more frequent. In this manner, the QIP takes on a more spiral approach rather than a waterfall. This paper describes the state of the FDD in the area of software development processes, as revealed through the understanding and assessing activities conducted by the COTS study team. The insights presented include: (1) a characterization of a typical FDD Commercial Off the Shelf (COTS) intensive software development life-cycle process, (2) lessons learned through the COTS study interviews, and (3) a description of changes in the SEL due to the changing and accelerating nature of software development in the FDD.
    Keywords: Computer Programming and Software
    Type: Software Engineering Laboratory Series: Proceedings of the Twenty-First Annual Software Engineering Workshop; 21-55; NASA/TM-1998-208618
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  • 8
    Publication Date: 2004-12-03
    Description: This paper presents the interim results from the Software Engineering Laboratory's (SEL) Reuse Study. The team conducting this study has, over the past few months, been studying the Generalized Support Software (GSS) domain asset library and architecture, and the various processes associated with it. In particular, we have characterized the process used to configure GSS-based attitude ground support systems (AGSS) to support satellite missions at NASA's Goddard Space Flight Center. To do this, we built detailed models of the tasks involved, the people who perform these tasks, and the interdependencies and information flows among these people. These models were based on information gleaned from numerous interviews with people involved in this process at various levels. We also analyzed effort data in order to determine the cost savings in moving from actual development of AGSSs to support each mission (which was necessary before GSS was available) to configuring AGSS software from the domain asset library. While characterizing the GSS process, we became aware of several interesting factors which affect the successful continued use of GSS. Many of these issues fall under the subject of evolving technologies, which were not available at the inception of GSS, but are now. Some of these technologies could be incorporated into the GSS process, thus making the whole asset library more usable. Other technologies are being considered as an alternative to the GSS process altogether. In this paper, we outline some of issues we will be considering in our continued study of GSS and the impact of evolving technologies.
    Keywords: Computer Programming and Software
    Type: Software Engineering Laboratory Series: Proceedings of the Twenty-First Annual Software Engineering Workshop; 27-58; NASA/TM-1998-208617
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  • 9
    Publication Date: 2004-12-03
    Description: The Chemical Management System (CMS) is a client/server application developed with Power Builder and Sybase for the Lewis Research Center (LeRC). Power Builder is a client-server application development tool, Sybase is a Relational Database Management System. The entire LeRC community can access the CMS from any desktop environment. The multiple functions and benefits of the CMS are addressed.
    Keywords: Inorganic and Physical Chemistry
    Type: Proceeding from the 1997 NASA Occupational Health Conference: Achieving Quality in Occupational Health; 169-171; NASA/CP-97-206321
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  • 10
    Publication Date: 2006-10-26
    Keywords: unknown
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