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  • 1
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    Molecular selection in a unified evolutionary sequence (1986)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: With guidance from experiments and observations that indicate internally limited phenomena, an outline of unified evolutionary sequence is inferred. Such unification is not visible for a context of random matrix and random mutation. The sequence proceeds from Big Bang through prebiotic matter, protocells, through the evolving cell via molecular and natural selection, to mind, behavior, and society.
    Keywords: Exobiology
    Type: International journal of quantum chemistry. Quantum biology symposium : proceedings of the International Symposium on Quantum Biology and Quantum Pharmacology. International Symposium on Quantum Biology and Quantum Pharmacology (ISSN 0360-8832); Volume 13; 223-35
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  • 2
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    The evolutionary sequence: origin and emergences (1986)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The evolutionary sequence is being reexamined experimentally from a "Big Bang"origin to the protocell and from the emergence of protocell and variety of species to Darwin's mental power (mind) and society (The Descent of Man). A most fundamentally revisionary consequence of experiments is an emphasis on endogenous ordering. This principle, seen vividly in ordered copolymerization of amino acids, has had new impact on the theory of Darwinian evolution and has been found to apply to the entire sequence. Herein, I will discuss some problems of dealing with teaching controversial subjects.
    Keywords: Exobiology
    Type: The American biology teacher (ISSN 0002-7685); Volume 48; 3; 140-9, 169
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  • 3
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    The development of rigorous tests for extraterrestrial life (1966)
    In:  CASI
    Details
    Publication Date: 2006-10-26
    Description: Rigorous tests for detecting extraterrestrial life
    Keywords: BIOSCIENCES
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  • 4
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    EXPERIMENTS RELATED TO THE CHEMICAL ORIGINS OF PROTEIN (1961)
    In:  CASI
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    Publication Date: 2006-10-26
    Description: Chemistry of the origin of protein
    Keywords: COMPUTERS
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  • 5
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    Protobiological informatoin, bidirectional recognition and reverse translation (1986)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Emergence of protobiological information has been suggested by experiments in which heated mixtures of alpha-amino acids order themselves into a self limited array of thermal proteins. The polymers display selective catalytic, hormonal, and other activities. Interactions of varied cationic thermal proteins with polynucleotides indicate selective recognition in both directions. Reverse translation is partly a missing link in the molecular evolution flowsheet. The self ordering of amino acids serves conceptually as a deterministic evolutionary precursor of the modern coding mechanism. The possibility for the evolution of information at an early nontemplated protein stage is supported by findings of electrical signals from proteinoid microspheres prepared with no DNA/RNA in their history. The deposition of thermal copolyamino acids on lipid membranes in the Mueller-Rudin apparatus has here been found to produce electrical behavior like that evoked by bacterial EIM polypeptide. A new procedure is to make a film of membrane on the electrode; the results provide maximal repeatability. The principle of nonrandom biomacromolecular specificity identified by these studies in molecular evolution have been extrapolated to principles of evolution of advanced organisms.
    Keywords: SPACE BIOLOGY
    Type: NASA, Washington Second Symposium on Chemical Evolution and the Origin and Evolution of Life; p 76
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  • 6
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    THE THERMAL COPOLYMERIZATION OF A-AMINO ACIDS (1961)
    In:  CASI
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    Publication Date: 2006-10-26
    Description: Thermal copolymerization of alpha-amino acids
    Keywords: COMPUTERS
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  • 7
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    From non-random molecular structure to life and mind (1989)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The evolutionary hierarchy molecular structure--〉macromolecular structure--〉protobiological structure--〉biological structure--〉biological functions has been traced by experiments. The sequence always moves through protein. Extension of the experiments traces the formation of nucleic acids instructed by proteins. The proteins themselves were, in this picture, instructed by the self-sequencing of precursor amino acids. While the sequence indicated explains the thread of the emergence of life, protein in cellular membrane also provides the only known material basis for the emergence of mind in the context of emergence of life.
    Keywords: Exobiology
    Type: Journal of molecular structure (ISSN 0022-2860); Volume 199; 183-8
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  • 8
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    ABIOTIC PRODUCTION OF PRIMITIVE PROTEIN AND FORMED MICROPARTICLES (1962)
    In:  CASI
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    Publication Date: 2012-03-11
    Description: Abiotic production of primitive protein and formed microparticles
    Keywords: MASERS
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  • 9
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    Thermal copoly/amino acids/ as inhibitors of glyoxalase I (1979)
    In:  Other Sources
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    Publication Date: 2011-08-17
    Description: A number of copoly(alpha-amino acids) have been prepared thermally; some have been found to function as inhibitors of glyoxalase I, an enzyme which occupies a central position in Szent-Gyorgyi's theory of tumour genesis. These polymers are also of interest in the search for synthetic peptides having carcinostatic activity, since many natural peptides are active. The way in which the inhibitory activity varies with composition of the synthetic polymers has been investigated. Various properties (hydrophobicity, molecular weight, UV absorption, kinetic type) have been examined in a search for correlates of inhibitory activity.
    Keywords: CHEMISTRY AND MATERIALS (GENERAL)
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  • 10
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    Origins of biological information and the genetic code (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: Information, defined as the capacity of a molecule or system for selective interactions with other molecules or systems, is followed through its evolution from prebiological information to protoribosomes. Emphasis is on proteins and protein-like polymers, and later on ATP. The research will contribute more to the understanding of the essence of the genetic mechanism.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: Molecular and Cellular Biochemistry; 3; Apr. 15
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