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  • Other Sources  (5)
  • 1980-1984  (5)
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  • 1
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    The effect of hypodynamia on mineral and protein metabolism in calcified tissues of the maxillodental system (experimental radioisotope study) (1980)
    In:  CASI
    Details
    Publication Date: 2019-08-13
    Description: Mineral and protein metabolism was studied in experiments on 60 white rats, using P-32 and Ca-45 uptake in the mineral fractions, 2C-14-glycine in the protein fractions, and P-32 in both fractions of calcified tissues as indices over a 100 day period of experimental hypodynamia. Combined alterations in mineral and protein metabolism occurred in the calcified tissues of the experimental animals. The most pronounced changes were found in P-32 and 2C-14-glycine metabolism. In the incisors and femoral bones, these alterations occurred in two phases: P-32 and 2C-14-glycine uptake first increased, then decreased. Changes in Ca-45 metabolism were less pronounced, particularly in the initial period of the experiment. A marked reduction in P-32, Ca-45, and 2C-14-glycine uptake was found in various fractions of the calcified tissues on the 100th day of experimental hypodynamia.
    Keywords: AEROSPACE MEDICINE
    Type: NASA-TM-75998
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 2
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    Mechanisms of water-salt metabolism disturbances in dogs subjected to six month hypokinesia (1980)
    In:  CASI
    Details
    Publication Date: 2019-08-27
    Description: Water-salt metabolism in dogs during prolonged restricted motor activity (hypokinesia) was investigated. It was found that hydration occurred and fluid was redistributed between the extra- and intra-cellular sectors. Also, electrolyte excretion rose, and magnetism and calcium metabolism changed significantly. It is concluded that the forces caused by muscle strain proper (which was decreased under conditions of hypokinesia) influence the state of bone metabolism.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: NASA-TM-76170
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 3
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    Ideas of I. M. Sechenov in aviation and space medicine (1980)
    In:  CASI
    Details
    Publication Date: 2019-08-27
    Description: The contributions I. M. Sechenov (19th century) made to modern physiology are described, including his studies on gases in the blood (O2 and CO2), and how these studies were the basic building blocks of current efforts in aviation and space medicine. Sechenov also studied hypokinesia, which is becoming important in long duration space flights.
    Keywords: AEROSPACE MEDICINE
    Type: NASA-TM-75976
    Format: application/pdf
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  • 4
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    Changes of the body functions during long-term hypokinesia (1980)
    In:  CASI
    Details
    Publication Date: 2019-08-28
    Description: Prolonged hypokinesis (100-170 days) studied in 2000 rats kept in cages limiting their mobility provoked considerable changes in the gaseous and energetic metabolism: an elevation of the total gaseous metabolism and of the rate of O2 requirement by the muscles (in the late periods of hypokinesis) and a change in the intensity of tissue respiration of the liver and myocardium. There also proved to be a reduction in the level of phosphorylation and separation of oxidative phosphorylation in the myocardium, liver, and partially in the skeletal muscle. Prolonged hypokinesia led to changes in tissue metabolism: a disturbance of development of the animals, a marked delay and an increase in the weight of the organism and the muscular system, and disturbances of the mineral and protein metabolism. Prolonged hypokinesis also lead to exhaustion of the hypothalamus-hypophysis-adrenal cortex system.
    Keywords: AEROSPACE MEDICINE
    Type: NASA-TM-76166
    Format: application/pdf
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  • 5
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    Life in motion, in motion! (1983)
    In:  CASI
    Details
    Publication Date: 2019-08-27
    Description: A 120 day limited mobility experiment with young male rats and its results, including retarded growth and degenerative changes in the cardiac muscle, are described. A 120 day strict bedrest experiment with 10 human volunteers and its results are described and discussed. Early subjective complaints, subsequent adaptation and eventual progressive changes in excitability and reactivity, reduction in functional capability of the cerebral cortex, and disturbances in water-salt, protein and fat metabolism, including development of precursors of atherosclerosis, as well as poor results of the orthostatic test after 4 months, are presented. These results are explained as applied to sedentary workers and recommendations are given for such persons to exercise in the morning, at work and in the evening in order to prevent hypokinesis and its physical, mental and physiological effects.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: NASA-TM-77202 , NAS 1.15:77202
    Format: application/pdf
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