Publication Date:
2015-04-29
Description:
Article RAS, identified over 30 years ago as a potent oncogene, is one of the most commonly mutated genes in cancer. Here the authors show that KR12, an alkylating reagent that specifically cleaves the DNA coding for the G12D and G12V activated variants of KRAS, limits the growth of KRAS mutant cells in vitro and in vivo . Nature Communications doi: 10.1038/ncomms7706 Authors: Kiriko Hiraoka, Takahiro Inoue, Rhys Dylan Taylor, Takayoshi Watanabe, Nobuko Koshikawa, Hiroyuki Yoda, Ken-ichi Shinohara, Atsushi Takatori, Hirokazu Sugimoto, Yoshiaki Maru, Tadamichi Denda, Kyoko Fujiwara, Allan Balmain, Toshinori Ozaki, Toshikazu Bando, Hiroshi Sugiyama, Hiroki Nagase
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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