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  • Articles  (67)
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  • 1
    facet.materialart.
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    Loss of Karma transposon methylation underlies the mantled somaclonal variant of oil palm (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-09-10
    Description: Somaclonal variation arises in plants and animals when differentiated somatic cells are induced into a pluripotent state, but the resulting clones differ from each other and from their parents. In agriculture, somaclonal variation has hindered the micropropagation of elite hybrids and genetically modified crops, but the mechanism responsible remains unknown. The oil palm fruit 'mantled' abnormality is a somaclonal variant arising from tissue culture that drastically reduces yield, and has largely halted efforts to clone elite hybrids for oil production. Widely regarded as an epigenetic phenomenon, 'mantling' has defied explanation, but here we identify the MANTLED locus using epigenome-wide association studies of the African oil palm Elaeis guineensis. DNA hypomethylation of a LINE retrotransposon related to rice Karma, in the intron of the homeotic gene DEFICIENS, is common to all mantled clones and is associated with alternative splicing and premature termination. Dense methylation near the Karma splice site (termed the Good Karma epiallele) predicts normal fruit set, whereas hypomethylation (the Bad Karma epiallele) predicts homeotic transformation, parthenocarpy and marked loss of yield. Loss of Karma methylation and of small RNA in tissue culture contributes to the origin of mantled, while restoration in spontaneous revertants accounts for non-Mendelian inheritance. The ability to predict and cull mantling at the plantlet stage will facilitate the introduction of higher performing clones and optimize environmentally sensitive land resources.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ong-Abdullah, Meilina -- Ordway, Jared M -- Jiang, Nan -- Ooi, Siew-Eng -- Kok, Sau-Yee -- Sarpan, Norashikin -- Azimi, Nuraziyan -- Hashim, Ahmad Tarmizi -- Ishak, Zamzuri -- Rosli, Samsul Kamal -- Malike, Fadila Ahmad -- Bakar, Nor Azwani Abu -- Marjuni, Marhalil -- Abdullah, Norziha -- Yaakub, Zulkifli -- Amiruddin, Mohd Din -- Nookiah, Rajanaidu -- Singh, Rajinder -- Low, Eng-Ti Leslie -- Chan, Kuang-Lim -- Azizi, Norazah -- Smith, Steven W -- Bacher, Blaire -- Budiman, Muhammad A -- Van Brunt, Andrew -- Wischmeyer, Corey -- Beil, Melissa -- Hogan, Michael -- Lakey, Nathan -- Lim, Chin-Ching -- Arulandoo, Xaviar -- Wong, Choo-Kien -- Choo, Chin-Nee -- Wong, Wei-Chee -- Kwan, Yen-Yen -- Alwee, Sharifah Shahrul Rabiah Syed -- Sambanthamurthi, Ravigadevi -- Martienssen, Robert A -- R01 GM067014/GM/NIGMS NIH HHS/ -- England -- Nature. 2015 Sep 24;525(7570):533-7. doi: 10.1038/nature15365. Epub 2015 Sep 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Malaysian Palm Oil Board, 6, Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor, Malaysia. ; Orion Genomics, 4041 Forest Park Avenue, St Louis, Missouri 63108, USA. ; United Plantations Berhad, Jendarata Estate, 36009 Teluk Intan, Perak, Malaysia. ; Applied Agricultural Resources Sdn Bhd, No. 11, Jalan Teknologi 3/6, Taman Sains Selangor 1, 47810 Kota Damansara, Petaling Jaya, Selangor, Malaysia. ; FELDA Global Ventures R&D Sdn Bhd, c/o FELDA Biotechnology Centre, PT 23417, Lengkuk Teknologi, 71760 Bandar Enstek, Negeri Sembilan, Malaysia. ; Howard Hughes Medical Institute-Gordon and Betty Moore Foundation, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26352475" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Alternative Splicing/genetics ; Arecaceae/*genetics/metabolism ; *DNA Methylation ; Epigenesis, Genetic/*genetics ; *Epigenomics ; Fruit/genetics ; Genes, Homeobox/genetics ; Genetic Association Studies ; Genome, Plant/*genetics ; Introns/genetics ; Molecular Sequence Data ; *Phenotype ; Plant Oils/analysis/metabolism ; RNA Splice Sites/genetics ; RNA, Small Interfering/genetics ; Retroelements/*genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    The oil palm SHELL gene controls oil yield and encodes a homologue of SEEDSTICK (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-07-26
    Description: A key event in the domestication and breeding of the oil palm Elaeis guineensis was loss of the thick coconut-like shell surrounding the kernel. Modern E. guineensis has three fruit forms, dura (thick-shelled), pisifera (shell-less) and tenera (thin-shelled), a hybrid between dura and pisifera. The pisifera palm is usually female-sterile. The tenera palm yields far more oil than dura, and is the basis for commercial palm oil production in all of southeast Asia. Here we describe the mapping and identification of the SHELL gene responsible for the different fruit forms. Using homozygosity mapping by sequencing, we found two independent mutations in the DNA-binding domain of a homologue of the MADS-box gene SEEDSTICK (STK, also known as AGAMOUS-LIKE 11), which controls ovule identity and seed development in Arabidopsis. The SHELL gene is responsible for the tenera phenotype in both cultivated and wild palms from sub-Saharan Africa, and our findings provide a genetic explanation for the single gene hybrid vigour (or heterosis) attributed to SHELL, via heterodimerization. This gene mutation explains the single most important economic trait in oil palm, and has implications for the competing interests of global edible oil production, biofuels and rainforest conservation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209285/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209285/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Singh, Rajinder -- Low, Eng-Ti Leslie -- Ooi, Leslie Cheng-Li -- Ong-Abdullah, Meilina -- Ting, Ngoot-Chin -- Nagappan, Jayanthi -- Nookiah, Rajanaidu -- Amiruddin, Mohd Din -- Rosli, Rozana -- Manaf, Mohamad Arif Abdul -- Chan, Kuang-Lim -- Halim, Mohd Amin -- Azizi, Norazah -- Lakey, Nathan -- Smith, Steven W -- Budiman, Muhammad A -- Hogan, Michael -- Bacher, Blaire -- Van Brunt, Andrew -- Wang, Chunyan -- Ordway, Jared M -- Sambanthamurthi, Ravigadevi -- Martienssen, Robert A -- R01 GM067014/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2013 Aug 15;500(7462):340-4. doi: 10.1038/nature12356. Epub 2013 Jul 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Malaysian Palm Oil Board, 6, Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor, Malaysia. raviga@mpob.gov.my〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23883930" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Arabidopsis Proteins/genetics ; Arecaceae/*genetics/*metabolism ; Chromosome Mapping ; Gene Expression Profiling ; Gene Expression Regulation, Plant ; Genes, Plant/*genetics ; Genetic Variation ; Homozygote ; MADS Domain Proteins/genetics ; Molecular Sequence Data ; Mutation ; *Plant Oils ; Sequence Alignment
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    Oil palm genome sequence reveals divergence of interfertile species in Old and New worlds (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-07-26
    Description: Oil palm is the most productive oil-bearing crop. Although it is planted on only 5% of the total world vegetable oil acreage, palm oil accounts for 33% of vegetable oil and 45% of edible oil worldwide, but increased cultivation competes with dwindling rainforest reserves. We report the 1.8-gigabase (Gb) genome sequence of the African oil palm Elaeis guineensis, the predominant source of worldwide oil production. A total of 1.535 Gb of assembled sequence and transcriptome data from 30 tissue types were used to predict at least 34,802 genes, including oil biosynthesis genes and homologues of WRINKLED1 (WRI1), and other transcriptional regulators, which are highly expressed in the kernel. We also report the draft sequence of the South American oil palm Elaeis oleifera, which has the same number of chromosomes (2n = 32) and produces fertile interspecific hybrids with E. guineensis but seems to have diverged in the New World. Segmental duplications of chromosome arms define the palaeotetraploid origin of palm trees. The oil palm sequence enables the discovery of genes for important traits as well as somaclonal epigenetic alterations that restrict the use of clones in commercial plantings, and should therefore help to achieve sustainability for biofuels and edible oils, reducing the rainforest footprint of this tropical plantation crop.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929164/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929164/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Singh, Rajinder -- Ong-Abdullah, Meilina -- Low, Eng-Ti Leslie -- Manaf, Mohamad Arif Abdul -- Rosli, Rozana -- Nookiah, Rajanaidu -- Ooi, Leslie Cheng-Li -- Ooi, Siew-Eng -- Chan, Kuang-Lim -- Halim, Mohd Amin -- Azizi, Norazah -- Nagappan, Jayanthi -- Bacher, Blaire -- Lakey, Nathan -- Smith, Steven W -- He, Dong -- Hogan, Michael -- Budiman, Muhammad A -- Lee, Ernest K -- DeSalle, Rob -- Kudrna, David -- Goicoechea, Jose Luis -- Wing, Rod A -- Wilson, Richard K -- Fulton, Robert S -- Ordway, Jared M -- Martienssen, Robert A -- Sambanthamurthi, Ravigadevi -- Howard Hughes Medical Institute/ -- England -- Nature. 2013 Aug 15;500(7462):335-9. doi: 10.1038/nature12309. Epub 2013 Jul 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Malaysian Palm Oil Board, 6, Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor, Malaysia. raviga@mpob.gov.my〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23883927" target="_blank"〉PubMed〈/a〉
    Keywords: Arecaceae/*classification/*genetics ; Carbohydrate Metabolism/genetics ; Chromosomes, Plant/genetics ; Genome, Plant/*genetics ; Lipid Metabolism/genetics ; Models, Genetic ; Molecular Sequence Data ; *Phylogeny
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    198AuNP-EGCg for prostate cancer therapy [Applied Biological Sciences] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-08-01
    Description: Systemic delivery of therapeutic agents to solid tumors is hindered by vascular and interstitial barriers. We hypothesized that prostate tumor specific epigallocatechin-gallate (EGCg) functionalized radioactive gold nanoparticles, when delivered intratumorally (IT), would circumvent transport barriers, resulting in targeted delivery of therapeutic payloads. The results described herein support our hypothesis. We report the development of inherently therapeutic gold nanoparticles derived from the Au-198 isotope; the range of the 198Au β-particle (approximately 11 mm in tissue or approximately 1100 cell diameters) is sufficiently long to provide cross-fire effects of a radiation dose delivered to cells within the prostate gland and short enough to minimize the radiation dose to critical tissues near the periphery of the capsule. The formulation of biocompatible 198AuNPs utilizes the redox chemistry of prostate tumor specific phytochemical EGCg as it converts gold salt into gold nanoparticles and also selectively binds with excellent affinity to Laminin67R receptors, which are over expressed in prostate tumor cells. Pharmacokinetic studies in PC-3 xenograft SCID mice showed approximately 72% retention of 198AuNP-EGCg in tumors 24 h after intratumoral administration. Therapeutic studies showed 80% reduction of tumor volumes after 28 d demonstrating significant inhibition of tumor growth compared to controls. This innovative nanotechnological approach serves as a basis for designing biocompatible target specific antineoplastic agents. This novel intratumorally injectable 198AuNP-EGCg nanotherapeutic agent may provide significant advances in oncology for use as an effective treatment for prostate and other solid tumors.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 5
    Electronic Resource
    Electronic Resource
    Constitutional isomeric effect on the dielectric relaxation of a nematic liquid crystalline polymethacrylate containing a methoxymethylstilbene side group (1993)
    s.l. : American Chemical Society
    Macromolecules 26 (1993), S. 6403-6409 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00076a016
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  • 6
    Electronic Resource
    Electronic Resource
    Polarographic Determination of Trace Quantities of Iodine (1957)
    s.l. : American Chemical Society
    Analytical chemistry 29 (1957), S. 301-303 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60122a038
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  • 7
    Electronic Resource
    Electronic Resource
    Seismic Cycles and the Evolution of Stress Correlation in Cellular Automaton Models of Finite Fault Networks (1999)
    Springer
    Pure and applied geophysics 155 (1999), S. 307-334 
    Details
    ISSN: 1420-9136
    Keywords: Key words: Regional seismicity, seismic cycle, cellular automation, critical point, fractals.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract —A cellular automaton is used to study the relation between the structure of a regional fault network and the temporal and spatial patterns of regional seismicity. Automata in which the cell sizes form discrete fractal hierarchies are compared with those having a uniform cell size. Conservative models in which all the stress is transferred at each step of a cascade are compared with nonconservative ("lossy") models in which a specified fraction of the stress energy is lost from each step. Particular attention is given to the behavior of the system as it is driven toward the critical state by uniform external loading. All automata exhibit a scaling region at times close to the critical state in which the events become larger and energy release increases as a power-law of the time to the critical state. For the hierarchical fractal automata, this power-law behavior is often modulated by fluctuations that are periodic in the logarithm of the time to criticality. These fluctuations are enhanced in the nonconservative models, but are not robust. The degree to which they develop appears to depend on the particular distribution of stresses in the larger cells which varies from cycle to cycle. Once the critical state is reached, seismicity in the uniform conservative automaton remains random in time, space, and magnitude. Large events do not significantly perturb the stress distribution in the system. However, large events in the nonconservative uniform automaton and in the fractal systems produce large stress perturbations that move the system out of the critical state. The result is a seismic cycle in which a large event is followed by a shadow period of quiescence and then a new approach back toward the critical state. This seismic cycle does not depend on the fractal structure, but is a direct consequence of large-scale heterogeneity of these systems in which the size of the largest cell (or the size of the largest nonconservative event) is a significant fraction of the size of the network. In essence, seismic cycles in these models are boundary effects. The largest events tend to cluster in time and the rate of small events remains relatively constant throughout a cycle in agreement with observed seismicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000240050267
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  • 8
    Electronic Resource
    Electronic Resource
    Meteorite Craters (1932)
    [s.l.] : Nature Publishing Group
    Nature 130 (1932), S. 26-26 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE very interesting article by Dr. L. J. Spencer on “Meteorite Craters”, in NATURE of May 28, suggests a possible explanation of the fact that, while the bedding of the surrounding country may be horizontal, the strata exposed in the inner walls of the crater usually dip radially outwards from ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/130026d0
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  • 9
    Electronic Resource
    Electronic Resource
    Surface Tension of Liquid Metals (1951)
    [s.l.] : Nature Publishing Group
    Nature 168 (1951), S. 343-344 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The implication of this relationship with regard to the penetration of liquid metals into compacted sand, to which they refer in the latter part of their communication, has, I think, some analogy to the behaviour of metals on the surfaces of cupels when undergoing cupellation in the process by ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/168343b0
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  • 10
    Electronic Resource
    Electronic Resource
    Formation of Widmanstätten Figures in Meteorites (1938)
    [s.l.] : Nature Publishing Group
    Nature 142 (1938), S. 1162-1162 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN a recent communication1, Prof. E. A. Owen advances a theory to account for the Widmanstätten figures in meteorites. He suggests that the meteorite is heated to a high temperature in its passage through the earth's atmosphere and is then suddenly, cooled on coming to rest in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1421162a0
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