ISSN:
0268-2605
Keywords:
organoantimony
;
carboxylate
;
crystal structure
;
antitumour
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Triorganoantimony(V) salicylates, [5-Y-2-(HO)-C6H3COO]2SbR3 (R=Me, Ph; Y=H, Me, MeO), were obtained by reacting R3SbCl2 with the appropriate sodium salt. The compounds have been characterized by IR, MS, 1H and 13C NMR spectroscopy. The molecular structure of the three substituted trimethylantimony(V) disalicylates has been determined by X-ray diffraction. The salicylate ligands are mono-coordinated to antimony through an oxygen atom of each carboxylate, leading to a trigonal bipyramidal geometry, with the antimony-methyl groups in equatorial positions and the oxygen atoms in axial positions. The trimethylantimony compounds tested in vitro against a series of human tumour cell lines were found to be inactive.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/aoc.590090715
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