ISSN:
0049-8246
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Physics
Notes:
A pilot study was undertaken with aluminium and strontium in order to determine the path taken when they enter an organism. Rabbits received an intramuscular injection of A1, and thin tissue cryo-sections and pelletized and incinerated samples were investigated by the PIXE method. The best PIXE detection limits (ca. 60 μg g-1 dry weight) were obtained for thin tissue samples. On the basis of the chemical similarity of Ca and Sr, Sr ions were used to mark the Ca incorporation in the mineralized tissue. At different times of gestation (20-30 d), pregnant rabbits received an intraperitoneal injection of Sr. The animals were killed 7 h after the injection and the hind legs and skulls of the embryos were subjected directly to micro-PIXE measurements. The results revealed that Sr incorporation in the embryo is an age-dependent process. The highest Sr concentrations were found for 24-d old embryos whereas at the end of gestation (30 d) the Sr concentration had decreased by a factor of ca. 10.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/xrs.1300200607
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