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  • Articles  (70)
  • 1985-1989  (70)
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  • 1
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    Specific expression of nuclear proto-oncogenes before entry into meiotic prophase of spermatogenesis (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-08-18
    Description: The expression of proto-oncogenes representative of several functional categories has been investigated during development of mouse male germ cells. The c-raf proto-oncogene and three members of the c-ras gene family were expressed in mitotically active stem cells, throughout the prophase of meiosis and to varying extents in post-meiotic cell types. In contrast, the nuclear proto-oncogenes c-fos, c-jun, and c-myc were specifically expressed at high levels in type B spermatogonia. High levels of c-myc and c-jun RNAs were also detected in spermatocytes early in the prophase of meiosis. The type B spermatogonia represent the last mitotic cell division before entry into meiotic prophase; therefore, these nuclear proto-oncogenes may be involved in altering programs of gene expression at this developmental transition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolfes, H -- Kogawa, K -- Millette, C F -- Cooper, G M -- CA 21082/CA/NCI NIH HHS/ -- CA 28946/CA/NCI NIH HHS/ -- HD 15269/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1989 Aug 18;245(4919):740-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dana-Farber Cancer Institute, Boston, MA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2475907" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Nucleus/*metabolism ; DNA-Binding Proteins/genetics ; *Gene Expression Regulation ; Male ; *Meiosis ; Mice ; Nucleic Acid Hybridization ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-fos ; Proto-Oncogene Proteins c-jun ; Proto-Oncogene Proteins c-myc ; Proto-Oncogene Proteins c-raf ; Proto-Oncogene Proteins p21(ras) ; *Proto-Oncogenes ; RNA/analysis ; Spermatids/metabolism ; Spermatocytes/metabolism ; *Spermatogenesis ; Spermatogonia/metabolism ; Spermatozoa/analysis/metabolism/*ultrastructure ; Transcription Factors/genetics ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
    Electronic Resource
    Electronic Resource
    STATISTICAL CONCEPTS AND THEIR APPLICATION IN PHOTOGRAMMETRY AND SURVEYING (1988)
    Oxford, UK : Blackwell Publishing Ltd
    The @photogrammetric record 12 (1988), S. 0 
    Details
    ISSN: 1477-9730
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying
    Notes: This paper was prepared as supporting documentation for a tutorial given by the authors under Photogrammetric Society auspices. The authors do not make any claims of novelty or innovation but they feel that the information contained in the paper will provide useful study material, especially for practitioners of photogrammetry and surveying. The following topics are covered: functional and stochastic models; the least squares process; statistical testing; optimal design methods; and numerical examples in the design of a horizontal control network and of a close range photogrammetric survey.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1477-9730.1988.tb00612.x
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  • 3
    Electronic Resource
    Electronic Resource
    ANALYTICAL PHOTOGRAMMETRY APPLIED TO NEPALESE SLOPE MORPHOLOGY (1987)
    Oxford, UK : Blackwell Publishing Ltd
    The @photogrammetric record 12 (1987), S. 0 
    Details
    ISSN: 1477-9730
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying
    Notes: Site procedures and methods of analytical close range photogrammetry are described. The derived data are discussed in relation to the geomorphology of unstable hill slopes in Nepal. Acquisition of low cost multispectral aerial photography for a study of overall slope erosion is also described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1477-9730.1987.tb00594.x
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  • 4
    Electronic Resource
    Electronic Resource
    THE EXTRACTION OF POSITIONAL DATA FROM HISTORICAL PHOTOGRAPHS AND THEIR APPLICATION TO GEOMORPHOLOGY (1989)
    Oxford, UK : Blackwell Publishing Ltd
    The @photogrammetric record 13 (1989), S. 0 
    Details
    ISSN: 1477-9730
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying
    Notes: A technique which enables spatial data to be obtained from historical photography is outlined. The method is applied to a 40 year sequence of oblique aerial photography of the Black Ven landslide in Dorset, England. Some of the possible data processing options are discussed and illustrated by some preliminary results produced from the Dorset landslide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1477-9730.1989.tb00647.x
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  • 5
    Electronic Resource
    Electronic Resource
    Clonal origin of haematopoietic colonies in the postnatal mouse liver (1986)
    [s.l.] : Nature Publishing Group
    Nature 319 (1986), S. 507-511 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Mouse chimaeras can be very useful for addressing problems of clonal development because they consist of a mixture of cells of two different genotypes, brought together by embryo aggregation or blastocyst injection at early stages of embryo development4. If a given structure in a chimaera is ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/319507a0
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  • 6
    Electronic Resource
    Electronic Resource
    Experimental determination of the branching ratios $$p\bar p \to 2\pi ^0 ,\pi ^0 \gamma $$ , and 2γ at rest (1987)
    Springer
    The European physical journal 35 (1987), S. 15-19 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The branching ratios of $$p\bar p$$ annihilations into the neutral final states 2π0, π0γ, and 2γ are measured by stopping antiprotons in liquid hydrogen. They are $$B_{2\pi ^0 } = \left( {2.06 \pm 0.14} \right) \times 10^{ - 4} $$ , $$B_{\pi ^0 \gamma } = \left( {1.74 \pm 0.22} \right) \times 10^{ - 5} $$ , andB γγ〈1.7×10−6 (95% c.l.).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01561050
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  • 7
    Electronic Resource
    Electronic Resource
    Cytopathic effects of the pathogenic Neisseria. Studies using human fallopian tube organ cultures and human nasopharyngeal organ cultures (1987)
    Springer
    Antonie van Leeuwenhoek 53 (1987), S. 575-584 
    Details
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Infection of mucosal surfaces by N. gonorrhoeae and N. meningitidis may result in inflammation indicating potential injury to host cells. We used human fallopian tube organ cultures (FTOC) and human nasopharyngeal organ cultures (NPOC) to study the mechanisms by which gonococci and meningococci damage human mucosal surfaces. Early in the course of FTOC infected with gonococci and NPOC infected with meningococci, damage was most apparent to ciliary activity. Loss of ciliary activity was accompanied by sloughing of ciliated cells. The damage to ciliated cells was not associated with attachment of gonococci or meningococci to these cells or the presence of organisms within ciliated cells. Infection with the commensal N. subflava did not result in significant damage to human FTOC or NPOC ciliary activity. LPS appears to be a major toxin of gonococci for human FTOC ciliated cells. Gonococcal peptidoglycan fragments also damage FTOC ciliary activity. Both piliated (P+) and nonpiliated (P-) gonococci and meningococci damage FTOC and NPOC ciliary activity, but P+ organisms damage ciliary activity more rapidly than P- organisms. Damage to FTOC ciliated cells was produced by 〈10 μg/ml of purified gonococcal and meningococcal LPS. By 1–2h after exposure to LPS, vesicles containing LPS were distributed throughout the cytoplasm of ciliated cells. Polymyxin B neutralized LPS-induced damage, suggesting that the lipid A portion of LPS was the toxic moiety. In contrast, purified gonococcal and meningococcal LPS at 100 μg/ml did not damage human NPOC or FTOC from rabbits, pigs and cows. These studies indicate that N. gonorrhoeae and possibly N. meningitidis damage ciliated epithelial celsl indirectly by release of toxins from the organisms. The differences in susceptibility of FTOC and NPOC to LPS may suggest changes in density of receptors for LPS and may help explain variation in severity of gonococcal and meningococcal interactions at different human mucosal surfaces.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00415519
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  • 8
    Electronic Resource
    Electronic Resource
    Interferon alfa-2b/melphalan/prednisone in previously untreated patients with multiple myeloma: a phase I–II trial (1987)
    Springer
    Investigational new drugs 5 (1987), S. S41 
    Details
    ISSN: 1573-0646
    Keywords: Interferon alfa-2b ; multiple myeloma ; melphalan ; prednisone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Interferon alfa-2b (Intron A; Schering Plough) has been shown to be active in advanced previously treated multiple myeloma (MM). Recent in vitro evidence has suggested synergy between cytotoxic agents and interferon alfa-2b. This phase I–II protocol was initiated to study interferon alfa-2b in combination with melphalan and prednisone. Groups of five patients received interferon alfa-2b twice-weekly for two weeks at dose levels of 0.5, 1.0, 2.0, 5.0 and 10.0×106 IU/m2. During week 2, melphalan (9 mg/m2) and prednisone (40 mg/m2) were administered concurrently with interferon alfa-2b followed by a rest period during nadir myelosuppression, the cycles being repeated every 28 days. Thirty patients were entered of whom 21 were Stage III, 3 Stage II and 6 Stage I. Median nadir WBC/mm3 and platelets/mm3 at the various dose levels are given in the table. Serious adverse reactions while on study included myocardial infarction, renal failure and leukopenia-related sepsis. Early response information is available. Twenty-six patients are evaluable for response. Seven have had progressive disease and 19 (69%) a partial response, the median duration was 11+ months. Interferon alfa-2b does not appear to antagonize melphalan/prednisone effectiveness and may be additive or synergistic. Full evaluation of this combination will be undertaken in randomized controlled trials which are now underway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00207262
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  • 9
    Electronic Resource
    Electronic Resource
    Characterization of C-11-SCH 23390 and its possible metabolites in primate blood using high performance liquid chromatography (1988)
    Springer
    Journal of radioanalytical and nuclear chemistry 125 (1988), S. 65-74 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract A selective dopamine D1 antagonist, SCH 23390, is routinely labelled with C-11 at our institution for use in imaging dopamine D1 receptors in primate brain using positron emission tomography.However, little is known about the metabolism of this compound. In this report, a method is presented for the HPLC characterization of SCH 23390 and its possible metabolites in blood using a liquid-solid extraction technique. This procedure was applied to the analysis of blood samples collected at time intervals from rhesus monkeys after the injection of C-11-SCH 23390. About 4 minutes after injection, polar metabolite(s) were found in the circulation. However, the amounts detected would not be expected to interfere with the analysis of brain PET scans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02041750
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  • 10
    Electronic Resource
    Electronic Resource
    Recombinant gamma interferon in advanced breast cancer: A phase II trial (1986)
    Springer
    Investigational new drugs 4 (1986), S. 377-381 
    Details
    ISSN: 1573-0646
    Keywords: recombinant interferon ; gamma interferon ; advanced breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Fifteen patients with advanced carcinoma of the breast who had failed prior chemotherapy, were treated with recombinant gamma interferon at a dose of 2mg/m2 (1mg = 2.4 × 107 international units) intravenously for five consecutive days every other week. The median patient age was 51 and all patients had a performance status of 0–2 (Karnofsky ≥ 50). Thirteen patients had two or three sites of metastatic disease and seven were estrogen receptor positive. No complete or partial responses were noted. Although some patients had brief periods of stable disease, almost all patients progressed after one or two courses. Only one patient was able to receive six courses of induction therapy and a brief course of maintenance. Flu-like symptoms and nausea were seen in all patients; vomiting and anorexia were frequent. Hepatic toxicity manifested by enzyme elevation was common and was most severe in patients with liver metastases. In this study a highly purified biologically active gamma interferon was not associated with anti-tumor activity in previously treated women with metastatic breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00173511
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