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  • Articles  (263)
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  • 1
    Publication Date: 2015-03-24
    Description: This work reports on up to 2.9  μ m lasing at 230 K of InP-based type-I quantum well lasers. This record long wavelength lasing is achieved by applying InP-based Sb-free structures with eight periods of strain-compensated InAs quantum wells grown on metamorphic In 0.8 Al 0.2 As template layers. The continuous-wave threshold current density is 797 A/cm 2 and the idealized extrapolated threshold current density for infinite cavity length is as low as 58 A/cm 2 per quantum well at 120 K. This scheme is a promising pathway for extending the wavelength range of type-I quantum well lasers on InP substrates.
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
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  • 2
    Publication Date: 2014-12-19
    Description: SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca2+-ATPase 2 Cell Death and Disease 5, e1581 (December 2014). doi:10.1038/cddis.2014.538 Authors: W Li, Z Ouyang, Q Zhang, L Wang, Y Shen, X Wu, Y Gu, Y Shu, B Yu, X Wu, Y Sun & Q Xu
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 3
    Publication Date: 2016-08-27
    Description: Actin-like MreB paralogs play important roles in cell shape maintenance, cell wall synthesis and the regulation of the D,L-endopeptidases, CwlO and LytE. The gram-positive bacteria, Bacillus amyloliquefaciens LL3, is a poly--glutamic acid (-PGA) producing strain that contains three MreB paralogs: MreB, Mbl and MreBH. In B. amyloliquefaciens , CwlO and LytE can degrade -PGA. In this study, we aimed to test the hypothesis that modulating transcript levels of MreB paralogs would alter the synthesis and degradation of -PGA. The results showed that overexpression or inhibition of MreB, Mbl or MreBH had distinct effects on cell morphology and the molecular weight of the -PGA products. In fermentation medium, cells of mreB inhibition mutant were 50.2% longer than LL3, and the -PGA titer increased by 55.7%. However, changing the expression level of mbl showed only slight effects on the morphology, -PGA molecular weight and titer. In the mreBH inhibition mutant, -PGA production and its molecular weight increased by 56.7% and 19.4%, respectively. These results confirmed our hypothesis that suppressing the expression of MreB paralogs might reduce -PGA degradation, and that improving the cell size could strengthen -PGA synthesis. This is the first report of enhanced -PGA production via suppression of actin-like MreB paralogs.
    Keywords: Biotechnology & Synthetic Biology
    Print ISSN: 0378-1097
    Electronic ISSN: 1574-6968
    Topics: Biology
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  • 4
    Publication Date: 2017-01-05
    Description: The human disease methylation database (DiseaseMeth,  http://bioinfo.hrbmu.edu.cn/diseasemeth/ ) is an interactive database that aims to present the most complete collection and annotation of aberrant DNA methylation in human diseases, especially various cancers. Recently, the high-throughput microarray and sequencing technologies have promoted the production of methylome data that contain comprehensive knowledge of human diseases. In this DiseaseMeth update, we have increased the number of samples from 3610 to 32 701, the number of diseases from 72 to 88 and the disease–gene associations from 216 201 to 679 602. DiseaseMeth version 2.0 provides an expanded comprehensive list of disease–gene associations based on manual curation from experimental studies and computational identification from high-throughput methylome data. Besides the data expansion, we also updated the search engine and visualization tools. In particular, we enhanced the differential analysis tools, which now enable online automated identification of DNA methylation abnormalities in human disease in a case-control or disease–disease manner. To facilitate further mining of the disease methylome, three new web tools were developed for cluster analysis, functional annotation and survival analysis. DiseaseMeth version 2.0 should be a useful resource platform for further understanding the molecular mechanisms of human diseases.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 5
    Publication Date: 2018-09-15
    Description: Author(s): Y. F. Li, W. Wang, W. Guo, C. Y. Gu, H. Y. Sun, L. He, J. Zhou, Z. B. Gu, Y. F. Nie, and X. Q. Pan As one of the rare ferromagnetic semiconductors, CrGeTe 3 has recently attracted a great deal of attention as a potential candidate for next-generation high-performance nano-spintronic devices. In this study, by combining density functional theory calculations and angle-resolved photoemission spectro... [Phys. Rev. B 98, 125127] Published Fri Sep 14, 2018
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 6
    Publication Date: 2016-01-21
    Description: This work reports on the demonstration of a short-wave infrared detector nearly lattice matched to InP substrate using quaternary InGaAsBi as the absorption layer. The bismuth content of about 3.2% has red-shifted the 50% cut-off wavelength from about 1.6  μ m to 2.1  μ m at room temperature, indicating a bandgap reduction of about 180 meV due to bismuth incorporation. The detector shows an encouraging dark current density of 2.4 × 10 −4 A/cm 2 at bias voltage of −10 mV at 300 K. This work shows the promising potential of InP-based lattice-matched InGaAsBi detectors for short-wave infrared detection.
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
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  • 7
    Publication Date: 2015-11-25
    Description: We report the effect of Bi surfactant on the properties of highly strained InAs/InGaAs triangular quantum wells grown on InP substrates. Reduced surface roughness, improved heterostructure interfaces and enhanced photoluminescence intensity at 2.2  μ m are observed by moderate Bi-mediated growth. The nonradiative processes are analysed based on temperature-dependent photoluminescence. It is confirmed that Bi incorporation is insignificant in the samples, whereas excessive Bi flux during the growth results in deteriorated performance. The surfactant effect of Bi is promising to improve InP-based highly strained structures while the excess of Bi flux needs to be avoided.
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
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  • 8
    Publication Date: 2015-06-02
    Description: Environment reconstruction is to rebuild the physical environment in the cyberspace using the sensory data collected by sensor networks, which is a fundamental method for human to understand the physical world in depth. A lot of basic scientific work such as nature discovery and organic evolution heavily relies on the environment reconstruction. However, gathering large amount of environmental data costs huge energy and storage space. The shortage of energy and storage resources has become a major problem in sensor networks for environment reconstruction applications. Motivated by exploiting the inherent feature of environmental data, in this paper, we design a novel data gathering protocol based on compressive sensing theory and time series analysis to further improve the resource efficiency. This protocol adapts the duty cycle and sensing probability of every sensor node according to the dynamic environment, which cannot only guarantee the reconstruction accuracy, but also save energy and storage resources. We implement the proposed protocol on a 51-node testbed and conduct the simulations based on three real datasets from Intel Indoor, GreenOrbs and Ocean Sense projects. Both the experiment and simulation performances demonstrate that our method significantly outperforms the conventional methods in terms of resource efficiency and reconstruction accuracy.
    Print ISSN: 0010-4620
    Electronic ISSN: 1460-2067
    Topics: Computer Science
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  • 9
    Publication Date: 2016-09-21
    Description: This work reports on InP-based metamorphic quantum well structures with bismuth incorporation for mid-infrared applications. InAs 1-x Bi x quantum well structures have been grown on InP-based metamorphic In 0.83 Al 0.17 As buffers and photoluminescence beyond 3.1  μ m has been achieved at 300 K, which is longer than the referenced InAs quantum well. X-ray diffraction, cross-sectional transmission electron microscopy, and energy dispersive X-ray spectroscopy measurements reveal clear interfaces of InAsBi quantum well with low bismuth, while more defects and bismuth inhomogeneity were observed as more bismuth was incorporated.
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
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  • 10
    Publication Date: 2011-03-30
    Description: The capability of Weather Research and Forecasting (WRF) model in the simulation of cirrus clouds has been examined, with a focus on the effects of radiative processes and vertical model resolution. We incorporate in WRF a new radiation module, referred to as the Fu-Liou-Gu scheme, which is an improvement and refinement based on the Fu-Liou scheme, particularly in reference to parameterization of the single-scattering properties of ice crystal size and shape. We conducted a number of real-time WRF simulations for cirrus cases that were observed in the coastal and western United States on 29–30 March 2007, and we compared these with available observations from Moderate Resolution Imaging Spectroradiometer (MODIS) and GOES visible and IR images over the same areas. Simulation results show that WRF is capable of generating reasonable cirrus cloud fields and their movement and dissipation processes, especially those associated with the large-scale frontal system. Radiative processes are important in cirrus cloud simulations by affecting the vertical thermal structure and hence convection. The newly implemented radiation module, the Fu-Liou-Gu scheme, has been demonstrated to work well in WRF and can be effectively used for studies related to cirrus cloud formation and evolution and aerosol-cloud-radiation interactions. With the newly implemented radiation scheme, the simulations of cloud cover and cloud and ice water path (CWP and IWP) have been improved for cirrus clouds, with a more consistent comparison with the corresponding MODIS observations in terms of CWP and IWP means and CWP frequency distribution, especially for optically thin cirrus with an improvement of about 20% in simulated mean IWP. The model-simulated ice crystal sizes have also been shown to be comparable to those determined from MODIS cloud products. Finally, we have demonstrated that model vertical resolution plays a significant role in cirrus cloud simulation in terms of altering vertical velocity field and the associated regional circulation.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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