ISSN:
0006-3525
Keywords:
cyclic decapeptides
;
cyclolinopeptide A
;
x-ray
;
nmr
;
conformation
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The conformational analysis of synthetic cyclodecapeptide c(Pro-Phe-Phe-Aib-Leu)2 related to the cyclolinopeptide A, in the solid state and solution, has been carried out by x-ray diffraction and nmr spectroscopy. The structure of the monoclinic form obtained from methanol [a = 11.351(5) Å, b = 27.455(2) Å, c = 12.716(8) Å, β = 99.65(3)°; space group P21; Z = 2] shows the presence of six intramolecular NH···CO hydrogen bonds, with formation of four turns (three of type I and one of type III) and two C16 ring structures. All peptide units are trans. The solution structure, as found by nmr, indicates that, at room temperature, the peptide is conformationally homogeneous; the structure determined is perfectly symmetrical and topologically similar to that found in the solid state. The cyclodecapeptide exhibits similar biological activity to cyclolinopeptide A. © 1997 John Wiley & Sons, Inc. Biopoly 40: 465-478, 1996
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
Permalink
