ISSN:
1573-8221
Keywords:
α1-acid glycoprotein
;
neoglycoconjugates
;
Inflammation
;
immunomodulation
;
complement
;
orosomucoid
;
free radicals
;
tumor necrosis factor
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Pseudo-α1-acid glycoprotein with carbohydrate chain ratio typical of native form was synthesized by a previously developed original technique of quantitative transfer of α1-acid glycoprotein carbohydrate chains to other polymeric carrier. Similarly to native glycoprotein, the semisynthetic analog inhibited lymphocyte proliferation and stimulated the production of antiinflammatory cytokines by peripheral blood mononuclear leukocytes. However, it possessed no antioxidant activity and did not inhibit complement activation by the alternative pathway. The role of carbohydrate and protein components of α1-acid glycoprotein molecule in the realization of its biological effects is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02439809
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