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  • GEOPHYSICS  (4)
  • Polymer and Materials Science  (3)
  • tolbutamide kinetics  (2)
  • 1975-1979  (9)
  • 1910-1914
  • 1900-1904
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  • 1
    Digitale Medien
    Digitale Medien
    Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance (1975)
    Springer
    European journal of clinical pharmacology 9 (1975), S. 219-227 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Rifampicin ; induction of drug metabolism ; hexobarbital kinetics ; tolbutamide kinetics ; plasma concentrations ; man
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Five healthy volunteers took 1.2 g rifampicin daily for 8 days, and before and afterwards each received hexobarbital (7.32 mg/kg) and tolbutamide (20 mg/kg) by i.v. infusion on two consecutive days. The plasma concentrations of the two drugs were determined during and after infusion. The average elimination half-life of hexobarbital had decreased from 325 to 122 min and of tolbutamide from 418 to 183 min following rifampicin treatment. It was calculated that the metabolic clearance of hexobarbital had increased about three-fold and that of tolbutamide more than two-fold. Significant changes in the distribution kinetics of the two drugs were not observed. The results suggest that rifampicin is capable of inducing drug metabolism in man, which leads to an increased rate of elimination of drugs that undergo biotransformation in the liver.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00614021
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 2
    Digitale Medien
    Digitale Medien
    Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance (1977)
    Springer
    European journal of clinical pharmacology 11 (1977), S. 287-293 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Rifampicin ; induction of drug metabolism ; cirrhosis ; cholestasis ; hexobarbital kinetics ; tolbutamide kinetics ; plasma concentrations
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Eleven patients with hepatic cirrhosis or cholestasis were treated with rifampicin for 7 to 132 days. Ten patients received hexobarbital (7.32 mg/kg) and five received tolbutamide (20 mg/kg) by i.v. infusion prior to and after rifampicin treatment; plasma concentrations of the two test compounds were determined during and after infusion. The average elimination half-life of hexobarbital had decreased from 624 to 262 min and that of tolbutamide from 292 to 160 min following rifampicin treatment. It was calculated that the metabolic clearance of hexobarbital had increased more than two-fold and that of tolbutamide almost two-fold. The results suggest that rifampicin is able to stimulate hepatic drug metabolism in patients with liver disease. It was apparent in general that the induction did not lead to improvement of hepatocellular function during disease as judged by laboratory findings.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00607679
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    Sulfur, Energy, and Environment. Von B. Meyer. Elsevier Scientific Publishing Company, Amsterdam - New York 1977, 1. Aufl., XII, 448 S., zahlr. Abb. u. Tab., Kunststoffeinbd., Dfl. 97.00. (1978)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 50 (1978), S. 561-561 
    Details
    ISSN: 0009-286X
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/cite.330500724
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 4
    Digitale Medien
    Digitale Medien
    Chemical Reactions as a Means of Separation: Sulfur Removal. Herausgeg. von B. L. Crynes. Marcel Dekker, Inc., New York - Base1 1977. 360 S., zahlr. Abb. u. Tab., geb., SFr 98,-. (1978)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 50 (1978), S. 698-698 
    Details
    ISSN: 0009-286X
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/cite.330500913
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 5
    Digitale Medien
    Digitale Medien
    Luftreinbpltung durch Adsorption, Absorption und Oxidation. Von W. Menig. Deutscher Fachschriften-Verlag, Braun & Co., Mainz - Wiesbaden 1977. 1. Aufl., 487 S., 137 Abb., 39 Bilder, 85 Tab., brosch., DM 79, -. (1978)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 50 (1978), S. 563-563 
    Details
    ISSN: 0009-286X
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/cite.330500729
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    facet.materialart.
    Unbekannt
    A meteor ablation-cluster ion atmospheric sodium theory (1979)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-06-27
    Beschreibung: Neutral and ionic forms of sodium form narrow, well-defined layers which peak in the 90-95 km altitude region at midlatitudes. A new theory for the sodium layer is presented, which is found to be in good agreement with existing atmospheric observations as well as available laboratory measurements of rate constants. The layer is believed to result naturally from a meteor ablation source over a chemical sink with vertical transport of Na(+) playing an important role in the layer shape and variation. While the neutral chemistry is believed to consist of chemical equilibrium between Na and NaO, the ion chemistry departs from earlier studies and considers a cluster ion scheme. It is possible that higher-order cluster ions of sodium play a role in the formation of aerosols, through attachment or ion-induced nucleation processes.
    Schlagwort(e): GEOPHYSICS
    Materialart: Geophysical Research Letters; 6; Mar. 197
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    facet.materialart.
    Unbekannt
    A cluster ion chemistry for the mesospheric sodium layer (1979)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-06-27
    Beschreibung: A cluster ion chemistry for sodium is developed which relates the Na(+) profile to the Na profile using reactions involving Na(+).N2, Na(+).CO2, and Na(+).H2O. Removal of sodium from the mesosphere is accomplished by the formation of higher order clusters of the form Na(+).(H2O)n which presumably precipitate to the lower atmosphere. This sink is most effective in the 80-85 km altitude range. The chemical equilibrium model is applied to experimental observations of the Na and Na(+) layers.
    Schlagwort(e): GEOPHYSICS
    Materialart: Journal of Atmospheric and Terrestrial Physics; 41; June 197
    Format: text
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  • 8
    facet.materialart.
    Unbekannt
    Theoretical and experimental studies of the atmospheric sodium layer (1978)
    In:  CASI
    Details
    Publikationsdatum: 2019-06-28
    Beschreibung: Atmospheric atomic sodium was studied with a laser radar system. Photocount data were processed using a digital filter to obtain continuous estimates of the sodium concentration versus altitude. Wave-like structures in the sodium layer were observed, and there was evidence for the presence of a standing wave in the layer. The bottomside of the layer was observed to undulate with a period of about 2 1/2 hours, and the layer was observed to broaden through the night. A meteor ablation-cluster ion theory of sodium was developed. The theory shows good agreement with existing atmospheric observations as well as laboratory measurements of rate constants.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA-CR-157770 , UILU-ENG-78-2501 , AR-79 , (ISSN 0568-0581)
    Format: application/pdf
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  • 9
    facet.materialart.
    Unbekannt
    Lidar observations of wave-like structure in the atmospheric sodium layer (1978)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-06-27
    Beschreibung: The University of Illinois (Urbana) lidar system has been developed to study the atmospheric sodium layer near 90 km altitude through the mechanism of resonance scattering. The photocount data are processed using digital smoothing filters to obtain continuous estimates of the sodium density versus altitude. The filter cutoff frequency is related to the height resolution and accuracy of the estimated profile. Lidar photocount data processed using this filtering technique show wave-like structures in the sodium layer which move downward with time. The waves have typical wavelengths of 3-15 km and phase velocities of less than 1 m/sec. The movement of these structures seems to be independent of the motion of the bottomside of the layer, which also has been observed to move up or down by as much as 2 km over a period of a few hours.
    Schlagwort(e): GEOPHYSICS
    Materialart: Geophysical Research Letters; 5; Aug. 197
    Format: text
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