ISSN:
1573-1111
Keywords:
cyclodextrin
;
tetrahydroharmane
;
tetrahydrobetacarboline
;
inclusion complexes
;
steady-state and time-resolved fluorescence
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The interactions between cyclodextrins and tetrahydroharmane, 1-methyl-1,2,3,4-tetrahydro-9H-pyrido/3,4-b/indole, have been investigated in pH 10.1 aqueous media. Absorption and fluorescence studies, together with lifetime measurements show that tetrahydroharmane forms ground state inclusion complexes with α-CD and β-CD but not with γ-CD. Steady state experiments detect only one kind of tetrahydroharmane-β-CD complex, whereas time resolved measurements reveal the existence of two different types of 1 : 1 association complexes. The results in α-CD are very similar to those in β-CD, but the interactions are much weaker.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008090723172
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