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  • lipopeptides  (2)
  • soil columns  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Experimental investigation of transport of strongly retained species by soil columns (1997)
    Springer
    Water, air & soil pollution 95 (1997), S. 337-351 
    Details
    ISSN: 1573-2932
    Keywords: transport ; soil columns ; breakthrough curves ; lead ; proton
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Column experiments have been extensively used in transport studies of major cations but few investigations are available on migration through soils of strongly retained species that are environmentally relevant (like heavy metals). By presenting some selected experiments (lead and proton step-breakthrough tests in different conditions), this study shows that the soil-column technique is also applicable in the case of species which exhibit very large retention factors. The use of very small soil columns (about 0.4 mL of pore volumes) combined with relatively high flow rates (0.1–0.3 mL min−1 ) allows to observe the entire breakthrough curve (adsorption and desorption front up to 5000 pore volumes) in reasonable experimental time, in reproducible conditions and without experimental drawbacks. In the adopted experimental conditions no kinetic effects, related to diffuse transport and sorption reaction were recognized; moreover, Peclet number was higher than 60. Consequently, it was possible to calculate the equilibrium isotherms from the diffuse fronts of the breakthrough. Knowledge that can be derived, concerning the reversibility of the adsorption process, the influence of complexation on the adsorption, the kinetics of complex formation, and the effect of dissolution on proton transport, is also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02406173
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    EXPERIMENTAL INVESTIGATION OF TRANSPORT OF STRONGLY RETAINED SPECIES BY SOIL COLUMNS (1997)
    Springer
    Water, air & soil pollution 95 (1997), S. 337-351 
    Details
    ISSN: 1573-2932
    Keywords: transport ; soil columns ; breakthrough curves ; lead ; proton
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Column experiments have been extensively used in transport studies of major cations but few investigations are available on migration through soils of strongly retained species that are environmentally relevant (like heavy metals). By presenting some selected experiments (lead and proton step-breakthrough tests in different conditions), this study shows that the soil-column technique is also applicable in the case of species which exhibit very large retention factors. The use of very small soil columns (about 0.4 mL of pore volumes) combined with relatively high flow rates (0.1–0.3 mL min-1 ) allows to observe the entire breakthrough curve (adsorption and desorption front up to 5000 pore volumes) in reasonable experimental time, in reproducible conditions and without experimental drawbacks. In the adopted experimental conditions no kinetic effects, related to diffuse transport and sorption reaction were recognized; moreover, Peclet number was higher than 60. Consequently, it was possible to calculate the equilibrium isotherms from the diffuse fronts of the breakthrough. Knowledge that can be derived, concerning the reversibility of the adsorption process, the influence of complexation on the adsorption, the kinetics of complex formation, and the effect of dissolution on proton transport, is also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026474015336
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Synthesis of lipopeptides of the immunodominant epitope hMBP(83–99) containing amide or C-C bond linked hydrophobic chains for the study of T cell response (1999)
    Springer
    International journal of peptide research and therapeutics 6 (1999), S. 51-59 
    Details
    ISSN: 1573-3904
    Keywords: 2-aminohexadecanoic acid ; hMBP ; lipidic α-amino acid ; lipopeptides ; T cell response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary We previously demonstrated that the lipopeptide of the myelin basic protein (MBP) immunodominant epitope in Lewis rat Palm-GpMBP(74-85) (Gp: guinea pig), which induced experimental autoimmune encephalomyelitisin vivo strongly increased the T cell proliferative responsein vitro. We extended this study to the human immunodominant epitope hMBP(83-99), synthesizing different lipophilic peptides bearing a hydrophobic chain linked through an amide or a C-C bond. To this aim, we developed a synthetic pathway for (±)-N-Fmoc-Ahd-OH (Ahd: 2-aminohexadecanoic acid) which was used to synthesize diastereomeric peptides which were successfully separated by reverse-phase high-performance liquid chromatography. MBP-specific T cell lines recognizing the immunodominant epitope hMBP(83-99) have been generated from patients affected by multiple sclerosis. Their proliferative response to the native peptide and to some lipoderivatives has been investigated. In contrast to the animal model, none of the investigated lipopeptides exhibited ‘superagonist’ activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02443618
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  • 4
    Electronic Resource
    Electronic Resource
    Synthesis of lipopeptides of the immunodominant epitope hMBP(83–99) containing amide or C-C bond linked hydrophobic chains for the study of T cell response (1999)
    Springer
    International journal of peptide research and therapeutics 6 (1999), S. 51-59 
    Details
    ISSN: 1573-3904
    Keywords: 2-aminohexadecanoic acid ; hMBP ; lipidic α-amino ; lipopeptides ; T cell response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract We previously demonstrated that the lipopeptide of the myelin basic protein (MBP) immunodominant epitope in Lewis rat Palm-GpMBP(74–85) (Gp: guinea pig), which induced experimental autoimmune encephalomyelitis in vivo strongly increased the T cell proliferative response in vitro. We extended this study to the human immunodominant epitope hMBP(83–99), synthesizing different lipophilic peptides bearing a hydrophobic chain linked through an amide or a C-C bond. To this aim, we developed a synthetic pathway for (±)-N-Fmoc-Ahd-OH (Ahd: 2-aminohexadecanoic acid) which was used to synthesize diastereomeric peptides which were successfully separated by reverse-phase high-performance liquid chromatography. MBP-specific T cell lines recognizing the immunodominant epitope hMBP(83–99) have been generated from patients affected by multiple sclerosis. Their proliferative response to the native peptide and to some lipoderivatives has been investigated. In contrast to the animal model, none of the investigated lipopeptides exhibited ‘superagonist’ activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008867427651
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    Paper (German National Licenses)
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