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  • 1
    Electronic Resource
    Electronic Resource
    The effect of orally administered triprolidine and pseudoephedrine singly and combined on histamine-induced skin reactions (1982)
    Springer
    European journal of clinical pharmacology 22 (1982), S. 411-412 
    Details
    ISSN: 1432-1041
    Keywords: histamine ; triprolidine ; pseudoephedrine ; flare ; wheal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of a single oral dose of triprolidine and pseudoephedrine, singly and combined, on histamine-induced wheal and flare reactions, was assessed in a fully randomised, placebo-controlled, double-blind crossover study. Triprolidine alone and the combination had a significantly greater effect (p〈0.05) in reducing skin reactions than pseudoephedrine alone or placebo, but there was no significant difference between triprolidine and the combination (p〈0.05).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542544
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  • 2
    Electronic Resource
    Electronic Resource
    A comparison of the bronchodilator action of pseudoephedrine and ephedrine in patients with reversible airway obstruction (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 107-109 
    Details
    ISSN: 1432-1041
    Keywords: pseudoephedrine ; ephedrine ; asthma ; bronchodilator ; reversible airway obstruction ; spirometry ; whole body plethysmography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A double-blind randomised cross-over study was performed on 12 subjects suffering from reversible airway obstruction (asthma) to determine the relative bronchodilator effects of oral pseudoephedrine 60 mg, pseudoephedrine 180 mg, ephedrine 25 mg and matched placebo. Spirometry was used to measure vital capacity and forced expired volume in 1 s, and whole body plethysmography was used to measure specific airway conductance. Measurements were recorded before each drug was given, and 1 h and 2 h after each drug. Reversibility of the airway obstruction on each day of the study was demonstrated by significant improvements in all parameters of lung function in response to 400 µg of isoprenaline inhaled after the 2-h measurement. No significant bronchodilator effect could be shown following the ingestion of pseudoephedrine 60 mg or 180 mg. Only a week bronchodilator effect was demonstrated after ephedrine 25 mg in that the percentage change in vital capacity at 2 h after ephedrine was greater than that following either dose of pseudoephedrine or the placebo. It is concluded that oral pseudoephedrine in single doses of 60 mg or 180 mg has no significant bronchodilator action in man, and that a single dose of up to 180 mg pseudoephedrine does not cause tachycardia or hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00545963
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    Paper (German National Licenses)
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