ISSN:
1573-501X
Keywords:
alkylthiobenzimidazole
;
combinatorial chemistry
;
phosphonium resin
;
solid phase synthesis
;
traceless linker
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Resin-bound triphenylphosphine was coupledto 4-fluoro-3-nitrobenzyl bromide, and2-alkylthiobenzimidazoles were synthesized onresin in 4 steps using standard chemistries. Cleavage of the compounds from the resin wasachieved with 10% NaOH in MeOH to leave amethyl group at the attachment point. A totalof 47 amines and 40 electrophiles wereevaluated, defining the scope of the reactions,culminating in the synthesis of an 80-membertest library of high purity as determined by HPLC.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1009696618386
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