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  • 1
    Electronic Resource
    Electronic Resource
    Protein Precoating of Polylactide Microspheres Containing a Lipophilic Immunopotentiator for Enhancement of Macrophage Phagocytosis and Activation (1989)
    Springer
    Pharmaceutical research 6 (1989), S. 296-301 
    Details
    ISSN: 1573-904X
    Keywords: polylactide microspheres ; macrophage ; phagocytosis ; antitumor activation ; gelatin ; immunopotentiator
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Biodegradable microspheres containing a lipophilic muramyl dipeptide, MDP-B30, were prepared from a L-lactic acid–glycolic acid copolymer. The effect of precoating the microspheres with water-soluble polymers including proteins on the antitumor activity of mouse peritoneal macrophages (Mφ) was investigated. Macrophages activated by phagocytosis of the microspheres exhibited growth inhibitory activity toward Meth-A tumor cells. The activity correlated with the extent of Mφ phagocytosis of the microspheres. Mφ phagocytosis was greatly augmented by gelatin precoating of the microspheres, resulting in a significant increase of in vitro antitumor activity of Mφ by the microspheres. However, potentiation of Mφ activity by gelatin precoating was minimal after intraperitoneal injection of the microspheres, but cross-linking of the coated gelatin with glutaraldehyde afforded potentiation of the antitumor activity in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015942306801
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  • 2
    Electronic Resource
    Electronic Resource
    Synthesis of Gelatin Microspheres Containing Interferon (1989)
    Springer
    Pharmaceutical research 6 (1989), S. 422-427 
    Details
    ISSN: 1573-904X
    Keywords: gelatin microspheres ; macrophages ; phagocytosis ; degradation ; interferon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Gelatin microspheres with a diameter less than 2 µm were synthesized by means of cross-linking with glutaraldehyde. When the microspheres were subjected to degradation in phosphate-buffered saline solution containing collagenase, the digestion of microspheres was found to decrease with increasing cross-linking. Interferon was incorporated in the microspheres at a high trapping efficiency, and the rate of interferon release from the microspheres was regulated by the extent of cross-linking with glutaraldehyde. Gelatin microspheres incorporating interferon-α were readily phagocytosed by macrophages, regardless of the extent of cross-linking, and the phagocytosed microspheres were observed to be degraded gradually in the interior of macrophages, resulting in the slow release of the incorporated interferon in the cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015991617704
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    Paper (German National Licenses)
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