ISSN:
1573-8221
Keywords:
morphine
;
prenatal period
;
offspring
;
pain sensitivity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract It is established that mature random-bred and Wistar rats exhibit the same level of pain sensitivity in the tail-flick test, but the analgetic effect of morphine (5 mg/kg) is variously expressed: marked hypalgesia is observed in mongrel but not in Wistar rats. Prenatal morphinization enhances the analgetic effect of morphine in both mongrel and Wistar rats. There is a direct correlation between the plasma morphine content in prenatally morphinized rats and their sensitivity to the analgetic action of morphine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02445015
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